S100A6 and IL15

Number of citations of the paper that reports this interaction (PubMedID 37759746)
234

Data Source:
BioGRID (pull down)

		S100A6	IL15
Description		S100 calcium binding protein A6	interleukin 15
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Golgi Apparatus Cytosol Nuclear Speck
	Molecular Function	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding	Cytokine Activity Cytokine Receptor Binding Protein Binding
	Biological Process	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Positive Regulation Of Cytokine Production NK T Cell Proliferation Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Macrophage Differentiation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Negative Regulation Of Cold-induced Thermogenesis
Pathways			Interleukin-15 signaling Interleukin-15 signaling
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Cefazolin
Diseases
GWAS		HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)	Insomnia ( 29520036) Malaria ( 31844061) Post-traumatic stress disorder symptoms in trauma-exposed soldiers ( 30999091) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53	9 interacting genes: APP IL15RA IL2RB IL2RG POLR1H S100A6 S100P STAT5B TRAF3
Entrez ID		6277	3600
HPRD ID		00237	02776
Ensembl ID		ENSG00000197956	ENSG00000164136
Uniprot IDs		P06703	P40933
PDB IDs		1K8U 1K96 1K9K 1K9P 2M1K 4YBH	2XQB 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?		Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation	Interleukin-15 Receptor Activity Interleukin-15-mediated Signaling Pathway Positive Regulation Of Endocytosis Interleukin-2 Binding Interleukin-2 Receptor Activity Cytokine-mediated Signaling Pathway Cytokine Receptor Activity Positive Regulation Of Phagocytosis Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Endocytosis Endosome Interleukin-2-mediated Signaling Pathway Regulation Of Phagocytosis Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell Activation Transition Metal Ion Binding Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of B Cell Differentiation Natural Killer Cell Differentiation Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Activation Regulation Of Vesicle-mediated Transport Immune System Process Positive Regulation Of Leukocyte Differentiation Leukocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of B Cell Differentiation Immune Response Regulation Of Lymphocyte Differentiation Cell Surface Regulation Of Cell Activation Cell Activation T Cell Differentiation In Thymus Lymphocyte Differentiation Regulation Of Natural Killer Cell Activation Protein Homodimerization Activity Natural Killer Cell Activation Coreceptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Mononuclear Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Transport Positive Regulation Of Lymphocyte Activation Regulation Of Immune System Process External Side Of Plasma Membrane
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