LEP and CLU

Number of citations of the paper that reports this interaction (PMID 12824284)
3

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo)

		LEP	CLU
Gene Name		leptin	clusterin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite
	Molecular Function	Hormone Activity Growth Factor Activity Peptide Hormone Receptor Binding	Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovulation From Ovarian Follicle Response To Hypoxia Positive Regulation Of Cytokine Production Placenta Development Response To Dietary Excess Glucose Metabolic Process Regulation Of Gluconeogenesis Energy Reserve Metabolic Process Glycerol Biosynthetic Process Fatty Acid Beta-oxidation Tyrosine Phosphorylation Of STAT Protein Female Pregnancy Circadian Rhythm Cholesterol Metabolic Process Bile Acid Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Adult Feeding Behavior Central Nervous System Neuron Development Insulin Secretion Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Appetite Response To Insulin Response To Vitamin E Leptin-mediated Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Bone Mineralization Involved In Bone Maturation Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Glucose Homeostasis Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Ion Transport Positive Regulation Of MAPK Cascade Regulation Of Fat Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Vasoconstriction Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Developmental Growth Regulation Of Insulin Secretion Regulation Of Steroid Biosynthetic Process Leukocyte Tethering Or Rolling Regulation Of Lipoprotein Lipid Oxidation Adipose Tissue Development Negative Regulation Of Cartilage Development Negative Regulation Of Glucagon Secretion Cellular Response To L-ascorbic Acid Cellular Response To Retinoic Acid Positive Regulation Of STAT Protein Import Into Nucleus Negative Regulation Of Glutamine Transport Positive Regulation Of Hepatic Stellate Cell Activation	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Signaling by Leptin Incretin synthesis, secretion, and inactivation	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)
Protein-Protein Interactions		10 interactors: A2M CLU CRP GHRL HK3 LEPR PRKAA2 SIGLEC6 STAT3 UCN	44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT
Entrez ID		3952	1191
HPRD ID		01249	01706
Ensembl ID		ENSG00000174697	ENSG00000120885
Uniprot IDs		A4D0Y8 P41159	P10909
PDB IDs		1AX8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Corticotropin Secretion Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Feeding Behavior Response To Organic Substance Generation Of Precursor Metabolites And Energy Negative Regulation Of Cell Death Regulation Of Response To Food Regulation Of Carbohydrate Metabolic Process Regulation Of Appetite Regulation Of Cellular Ketone Metabolic Process Protein Activation Cascade Regulation Of Cytokine Production Regulation Of Glycolytic Process Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Glucose Homeostasis Response To Estrogen Secretion Transport Acute-phase Response Regulation Of Vasodilation Regulation Of Cell Death Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Cellular Metabolic Process Lipid Transport Signaling Lipid Localization Chemical Homeostasis Neurogenesis Negative Regulation Of Hormone Secretion Cell Communication Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Platelet Degranulation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Response To Hormone Acute Inflammatory Response Positive Regulation Of Tau-protein Kinase Activity Cortisol Secretion Regulation Of Neuronal Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Microglial Cell Proliferation Response To External Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion	Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?		aep amplitudes analgesic analog auditory categorical deteriorated enlarged errors evoked investigates mood morphine n1 neurophysiological oddball p2 pain perceptual potentials rated ratings reflected scales sedation stressor subjective vas vigilance	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Difference) ?		aep amplitudes analgesic analog auditory categorical deteriorated enlarged errors evoked investigates mood morphine n1 neurophysiological oddball p2 pain perceptual potentials rated ratings reflected scales sedation stressor subjective vas vigilance	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Intersection) ?