LEP and LEPR

Number of citations: 0 (PubMedID 8608603)
Data Source: HPRD (in vivo)

		LEP	LEPR
Name		leptin	leptin receptor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	DNA Binding Signaling Receptor Binding Hormone Activity Protein Binding Peptide Hormone Receptor Binding Leptin Receptor Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity Signaling Receptor Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovulation From Ovarian Follicle Response To Hypoxia Positive Regulation Of Cytokine Production Placenta Development Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Cardiac Muscle Hypertrophy Glucose Metabolic Process Regulation Of Gluconeogenesis Energy Reserve Metabolic Process Glycerol Biosynthetic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Phagocytosis Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Female Pregnancy Response To Nutrient Circadian Rhythm Cholesterol Metabolic Process Bile Acid Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Adult Feeding Behavior Fatty Acid Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Autophagy Negative Regulation Of Lipid Storage Response To Activity Regulation Of Metabolic Process Sexual Reproduction Central Nervous System Neuron Development Insulin Secretion T Cell Differentiation Regulation Of Intestinal Cholesterol Absorption Response To Nutrient Levels Positive Regulation Of TOR Signaling Negative Regulation Of Appetite Prostaglandin Secretion Response To Estradiol Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Proliferation Response To Insulin Cellular Response To Insulin Stimulus Response To Vitamin E Leptin-mediated Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Intracellular Signal Transduction Bone Mineralization Involved In Bone Maturation Aorta Development Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Import Into Nucleus Hormone Metabolic Process Glucose Homeostasis Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of MAPK Cascade Cellular Response To Leptin Stimulus Response To Ethanol Regulation Of Fat Cell Differentiation Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Negative Regulation Of D-glucose Import Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of Bone Remodeling Positive Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Lipid Biosynthetic Process Positive Regulation Of Developmental Growth Regulation Of Insulin Secretion Regulation Of Steroid Biosynthetic Process Intestinal Absorption Leukocyte Tethering Or Rolling Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Transport Elastin Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Lipoprotein Lipid Oxidation Adipose Tissue Development Negative Regulation Of Cartilage Development Negative Regulation Of Glucagon Secretion Cellular Response To L-ascorbic Acid Cellular Response To Retinoic Acid Regulation Of Brown Fat Cell Differentiation Energy Homeostasis Cell Surface Receptor Signaling Pathway Via STAT Bone Growth Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Fat Cell Apoptotic Process Activation Of Protein Kinase C Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Glutamine Transport Positive Regulation Of Hepatic Stellate Cell Activation	Angiogenesis Glycogen Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy Glial Cell Proliferation Cytokine-mediated Signaling Pathway Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling System Development Regulation Of Transport Regulation Of Feeding Behavior Energy Homeostasis Cell Surface Receptor Signaling Pathway Via STAT Bone Growth Positive Regulation Of Cold-induced Thermogenesis Transport Across Blood-brain Barrier
Pathways		Signaling by Leptin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and deacylation of Ghrelin	None
Drugs		None	Leptin Metreleptin
GWAS		BMI at 1.5 years old ( 31575865 ) BMI at 8 months old ( 31575865 ) Body size at age 10 ( 32376654 ) circulating leptin levels ( 26833098 32917775 ) circulating leptin levels adjusted for BMI ( 26833098 32917775 ) High density lipoprotein cholesterol levels ( 29403010 ) Interleukin-6 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683 ) Type 2 diabetes ( 23945395 26818947 32499647 )	Adult body size ( 32376654 ) Age at voice drop ( 27182965 ) Alanine aminotransferase levels ( 34315874 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Blood protein levels ( 30072576 ) BMI at 1 year old ( 31575865 ) BMI at 1.5 years old ( 31575865 ) BMI at 3 months old ( 31575865 ) BMI at 6 months old ( 31575865 ) BMI at 8 months old ( 31575865 ) BMI at adiposity peak ( 31840077 ) Body size at age 10 ( 32376654 ) C-reactive protein ( 23844046 18439548 22939635 19567438 ) C-reactive protein levels ( 33339817 21300955 29878111 30388399 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Eosinophil percentage of white cells ( 32888494 ) Fasting plasma glucose (childhood) ( 25223902 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Granulocyte count ( 27863252 ) HDL cholesterol levels ( 32203549 ) Hemoglobin ( 32888494 ) Hip circumference ( 28552196 ) Iron status biomarkers (iron levels) ( 33536631 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Menarche (age at onset) ( 25231870 ) Metabolic traits ( 19060910 ) Molybdenum levels ( 26025379 ) Monocyte percentage of white cells ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Nonalcoholic steatohepatitis ( 32298765 ) Obesity (early onset extreme) ( 23563609 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Soluble leptin receptor levels ( 20167575 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 27863252 )
Interacting Genes		12 interacting genes: A2M CLU CRP GHRL HK3 HSF2BP LEPR PRKAA2 S100A6 S100P SIGLEC6 UCN	17 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 USP7 XRN1
Entrez ID		3952	3953
HPRD ID		01249	03001
Ensembl ID		ENSG00000174697	ENSG00000116678
Uniprot IDs		A4D0Y8 P41159	P48357 Q4G138
PDB IDs		1AX8 7Z3Q 8AVE 8AVF 8AVO 8K6Z 8X80 8X81 8X85	3V6O 6E2P 7Z3Q 8AVE 8AVF 8AVO 8X80 8X81 8X85
GO Terms Enriched among Interactors		Extracellular Region Regulation Of Feeding Behavior Positive Regulation Of Corticotropin Secretion Regulation Of Corticotropin Secretion Calcium-dependent Protein Binding Regulation Of Behavior Negative Regulation Of Complement Activation Secretory Granule Lumen Regulation Of Response To Food Glucose Metabolic Process Regulation Of Complement Activation Regulation Of Appetite Low-density Lipoprotein Particle Receptor Binding Glial Cell Proliferation Hexose Metabolic Process Positive Regulation Of Behavior Monosaccharide Metabolic Process Regulation Of Response To Nutrient Levels Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Humoral Immune Response Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Leptin Receptor Activity Response To Hormone Positive Regulation Of Muscle Contraction Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Protein Localization To Lysosome Vascular Process In Circulatory System Platelet Alpha Granule Lumen Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Circulatory System Process Generation Of Precursor Metabolites And Energy Energy Homeostasis [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Negative Regulation Of Hormone Secretion G Protein-coupled Receptor Binding Histone Deacetylase Inhibitor Activity Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Feeding Behavior Interleukin-8 Binding Regulation Of Cytokine Production	Leptin Receptor Binding Retromer, Tubulation Complex Insulin Receptor Binding Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Peptide Hormone Receptor Binding Transferrin Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Metabolic Process Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Autophagy Retromer Complex Negative Regulation Of Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Cytosol Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Autophagy Phosphatidylinositol Binding Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Regulation Of Hormone Secretion Regulation Of Intracellular Transport Epidermal Growth Factor Receptor Binding Regulation Of Nucleocytoplasmic Transport Regulation Of Transport Regulation Of Immune System Process Regulation Of Defense Response Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hormone Secretion Establishment Of Protein Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Regulation Of Protein Localization To Nucleus