S100A6 and ANXA2

Number of citations of the paper that reports this interaction (PMID 1999197)
5

Data Source:
HPRD (in vitro)

		S100A6	ANXA2
Gene Name		S100 calcium binding protein A6	annexin A2
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Nuclear Envelope Cytoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Ruffle Basement Membrane Extracellular Space Nucleus Lysosomal Membrane Endosome Early Endosome Lipid Particle Plasma Membrane Cell Cortex Cell Surface Membrane Extrinsic Component Of Plasma Membrane Midbody Extracellular Matrix Late Endosome Membrane Vesicle Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Protein Complex Macropinosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Ion Transmembrane Transporter Activity Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Rab GTPase Binding Phospholipase A2 Inhibitor Activity S100 Protein Binding Poly(A) RNA Binding Calcium-dependent Protein Binding
	Biological Process	Signal Transduction Axonogenesis Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation	Angiogenesis Membrane Raft Assembly Positive Regulation Of Protein Phosphorylation Membrane Budding Body Fluid Secretion Collagen Fibril Organization Positive Regulation Of Vesicle Fusion Osteoclast Development Fibrinolysis Negative Regulation Of Catalytic Activity Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Binding Protein Heterotetramerization Protein Targeting To Plasma Membrane
Pathways			Dissolution of Fibrin Clot Orphan transporters
Drugs			Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ANXA11 ANXA2 CACYBP FKBP4 GAPDH MDM2 PEX5 PPID S100B SUGT1 TP53	31 interactors: APOH APP CD99 CDC42 CEACAM1 CTSB DYSF GRB2 HMGA1 LGALS13 LYPLA1 MAP3K4 MYOC PHB PLA1A PLAT PLG POT1 PRKCA PRKCB S100A10 S100A4 S100A6 SOS1 SRC STAT6 TERF1 TERT TP53 TRPV5 YWHAQ
Entrez ID		6277	302
HPRD ID		00237	01061
Ensembl ID		ENSG00000197956	ENSG00000182718
Uniprot IDs		P06703	P07355
PDB IDs		1K8U 1K96 1K9K 1K9P	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4HRH
Enriched GO Terms of Interacting Partners?		Cellular Response To UV Protein Complex Assembly Cellular Response To Light Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Tetramerization Cellular Response To Oxygen Levels Response To UV Cellular Response To Radiation Response To Abiotic Stimulus Regulation Of Protein Oligomerization Cellular Component Assembly Protein Localization Immune Response Immune System Process Regulation Of Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Process Positive Regulation Of Transport Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitochondrial Membrane Organization Establishment Of Protein Localization Response To Hypoxia Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Response To Antibiotic Innate Immune Response Regulation Of Cell Death Chaperone-mediated Protein Folding Response To Metal Ion Neuron Death Regulation Of Protein Complex Assembly Response To Light Stimulus Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Steroid Hormone Receptor Complex Assembly Peptidyl-cysteine S-trans-nitrosylation Cellular Response To UV-C Cellular Response To Vitamin B1 Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-amino Acid Modification Protein Peptidyl-prolyl Isomerization Regulation Of Fibroblast Proliferation Apoptotic Process Protein Targeting Signal Transduction In Response To DNA Damage	Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Platelet Activation Positive Regulation Of Cellular Component Biogenesis Leukocyte Migration Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization ERBB Signaling Pathway Cell Activation Regulation Of Signaling Telomere Maintenance Via Telomerase Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Developmental Process Regulation Of Apoptotic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Histone H3-T6 Phosphorylation Cellular Component Assembly Regulation Of Cell Death Epidermal Growth Factor Receptor Signaling Pathway Cell Aging Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity RNA-dependent DNA Replication Regulation Of ERBB Signaling Pathway Age-dependent Telomere Shortening Telomere Formation Via Telomerase Regulation Of Cell-substrate Adhesion Negative Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Adhesion Immune System Process Cell Migration Regulation Of Blood Coagulation Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Organization
Tagcloud ?		125i annexin ascites ca2 calcyclin cellulose chromatography chymotrypsin database dehydrogenase depended digested eat ehrlich evidenced extracts gel glyceraldehyde homogeneity ions labelled overlay p30 phenyl purified search sepharose similarity spleen	annexin apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Difference) ?		125i ascites ca2 calcyclin cellulose chromatography chymotrypsin database dehydrogenase depended digested eat ehrlich evidenced extracts gel glyceraldehyde homogeneity ions labelled overlay p30 phenyl purified search sepharose similarity spleen	apoptotic biological biomarker candidate collectively contributes encoding fully gemcitabine herein intracellular kappab localization mediates mia nf nucleus p50 paca2 pancreatic resting suppresses translocated understood upregulated upregulation y23a
Tagcloud (Intersection) ?		annexin