S100A6 and PRL

Number of citations of the paper that reports this interaction (PubMedID 37759746)
234

Data Source:
BioGRID (pull down)

		S100A6	PRL
Description		S100 calcium binding protein A6	prolactin
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Endosome Lumen Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding	Prolactin Receptor Binding Hormone Activity Protein Binding
	Biological Process	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation	Negative Regulation Of Endothelial Cell Proliferation Cell Surface Receptor Signaling Pathway Female Pregnancy Lactation Negative Regulation Of Angiogenesis Mammary Gland Development Response To Nutrient Levels Prolactin Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of MiRNA Transcription Positive Regulation Of Lactation
Pathways			Prolactin receptor signaling Prolactin receptor signaling Amyloid fiber formation Growth hormone receptor signaling Developmental Lineage of Mammary Gland Alveolar Cells
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease ( 30804561) Obesity ( 19151714) Paget's disease ( 21623375) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278)
Interacting Genes		50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53	6 interacting genes: MEOX2 PPIB PRLR S100A6 S100P UBQLN4
Entrez ID		6277	5617
HPRD ID		00237	07180
Ensembl ID		ENSG00000197956	ENSG00000172179
Uniprot IDs		P06703	P01236 Q5I0G2 Q5THQ0
PDB IDs		1K8U 1K96 1K9K 1K9P 2M1K 4YBH	1RW5 2Q98 3D48 3EW3 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 3NPZ
Enriched GO Terms of Interacting Partners?		Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation	Positive Regulation Of Sphingolipid Mediated Signaling Pathway Endothelial Cell Migration Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity High Density Lipoprotein Particle Mediated Signaling Lipopolysaccharide Transport Prolactin Receptor Activity Calcium-dependent Protein Binding Nuclear Proteasome Complex Positive Regulation Of Nitric Oxide Mediated Signal Transduction Detection Of Lipopolysaccharide Apolipoprotein A-I Binding Regulation Of Phosphatidylcholine Catabolic Process Somite Specification Perinuclear Region Of Cytoplasm Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Autophagosome Maturation Cytosolic Proteasome Complex
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