S100A6 and IL3

Number of citations of the paper that reports this interaction (PubMedID 37759746)
234

Data Source:
BioGRID (pull down)

		S100A6	IL3
Description		S100 calcium binding protein A6	interleukin 3
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding	Cytokine Activity Interleukin-3 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation	Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Embryonic Hemopoiesis Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT
Pathways			Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade RUNX1 regulates transcription of genes involved in interleukin signaling Interleukin receptor SHC signaling
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Amlexanox Zinc Polaprezinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)	Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 21102463 22412388 28067908) Inflammatory bowel disease ( 23128233 28067908) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatoid arthritis ( 24390342 30423114) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53	7 interacting genes: CSF2RB HRAS IL3RA PIK3CA PIK3CD S100A6 S100P
Entrez ID		6277	3562
HPRD ID		00237	00987
Ensembl ID		ENSG00000197956	ENSG00000164399
Uniprot IDs		P06703	P08700
PDB IDs		1K8U 1K96 1K9K 1K9P 2M1K 4YBH	1JLI 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?		Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation	Interleukin-3 Receptor Activity Regulation Of Cell Population Proliferation Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol 3-kinase Complex Positive Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Activity Signal Transduction T Cell Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death ATP-dependent Protein Folding Chaperone Regulation Of Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune System Process Regulation Of Cytoskeleton Organization Cytokine Receptor Activity Adipose Tissue Development Regulation Of Cell Cycle Regulation Of Erythrocyte Differentiation Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Positive Regulation Of Fibroblast Proliferation RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein Folding Chaperone Immune System Process Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Heat Shock Protein Binding Regulation Of Microtubule Polymerization Adaptive Immune Response Perinuclear Region Of Cytoplasm Connective Tissue Development Interleukin-5 Receptor Activity Insulin Receptor Signaling Pathway GTPase Complex Denatured Protein Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
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