LEP and SIGLEC6

Number of citations of the paper that reports this interaction (PMID 10428856)
18

Data Source:
HPRD (in vitro)

		LEP	SIGLEC6
Gene Name		leptin	sialic acid binding Ig-like lectin 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Integral Component Of Plasma Membrane Membrane
	Molecular Function	Hormone Activity Growth Factor Activity Peptide Hormone Receptor Binding	Carbohydrate Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovulation From Ovarian Follicle Response To Hypoxia Positive Regulation Of Cytokine Production Placenta Development Response To Dietary Excess Glucose Metabolic Process Regulation Of Gluconeogenesis Energy Reserve Metabolic Process Glycerol Biosynthetic Process Fatty Acid Beta-oxidation Tyrosine Phosphorylation Of STAT Protein Female Pregnancy Circadian Rhythm Cholesterol Metabolic Process Bile Acid Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Adult Feeding Behavior Central Nervous System Neuron Development Insulin Secretion Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Appetite Response To Insulin Response To Vitamin E Leptin-mediated Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Bone Mineralization Involved In Bone Maturation Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Glucose Homeostasis Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Ion Transport Positive Regulation Of MAPK Cascade Regulation Of Fat Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Vasoconstriction Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Developmental Growth Regulation Of Insulin Secretion Regulation Of Steroid Biosynthetic Process Leukocyte Tethering Or Rolling Regulation Of Lipoprotein Lipid Oxidation Adipose Tissue Development Negative Regulation Of Cartilage Development Negative Regulation Of Glucagon Secretion Cellular Response To L-ascorbic Acid Cellular Response To Retinoic Acid Positive Regulation Of STAT Protein Import Into Nucleus Negative Regulation Of Glutamine Transport Positive Regulation Of Hepatic Stellate Cell Activation	Cell Adhesion Cell-cell Signaling
Pathways		Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Signaling by Leptin Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: A2M CLU CRP GHRL HK3 LEPR PRKAA2 SIGLEC6 STAT3 UCN	3 interactors: FHL2 LEP TCF4
Entrez ID		3952	946
HPRD ID		01249	16058
Ensembl ID		ENSG00000174697	ENSG00000105492
Uniprot IDs		A4D0Y8 P41159	O43699
PDB IDs		1AX8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Corticotropin Secretion Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Feeding Behavior Response To Organic Substance Generation Of Precursor Metabolites And Energy Negative Regulation Of Cell Death Regulation Of Response To Food Regulation Of Carbohydrate Metabolic Process Regulation Of Appetite Regulation Of Cellular Ketone Metabolic Process Protein Activation Cascade Regulation Of Cytokine Production Regulation Of Glycolytic Process Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Glucose Homeostasis Response To Estrogen Secretion Transport Acute-phase Response Regulation Of Vasodilation Regulation Of Cell Death Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Cellular Metabolic Process Lipid Transport Signaling Lipid Localization Chemical Homeostasis Neurogenesis Negative Regulation Of Hormone Secretion Cell Communication Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Platelet Degranulation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Response To Hormone Acute Inflammatory Response Positive Regulation Of Tau-protein Kinase Activity Cortisol Secretion Regulation Of Neuronal Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Microglial Cell Proliferation Response To External Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion	Ossification Regulation Of Gluconeogenesis Bone Mineralization Biomineral Tissue Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Secretion Regulation Of Glucose Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cell Death Regulation Of Fat Cell Differentiation Regulation Of Lipid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Energy Reserve Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Glucose Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To L-ascorbic Acid Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Intracellular Protein Transport Cellular Response To Nutrient Levels Negative Regulation Of Gene Expression Response To Carbohydrate Negative Regulation Of Biosynthetic Process Regulation Of Insulin Secretion Glucose Homeostasis Hexose Metabolic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Hepatic Stellate Cell Activation Catenin Import Into Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Apoptotic Process Cellular Response To Extracellular Stimulus Regulation Of Peptide Hormone Secretion Cellular Carbohydrate Metabolic Process Regulation Of Cell Death Positive Regulation Of Intracellular Transport Monosaccharide Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Negative Regulation Of Vasoconstriction Atrial Cardiac Muscle Cell Development Glycerol Biosynthetic Process Negative Regulation Of Glucagon Secretion Regulation Of Lipoprotein Lipid Oxidation Regulation Of Intracellular Protein Transport Regulation Of Hormone Secretion Tissue Development
Tagcloud ?		aep amplitudes analgesic analog auditory categorical deteriorated enlarged errors evoked investigates mood morphine n1 neurophysiological oddball p2 pain perceptual potentials rated ratings reflected scales sedation stressor subjective vas vigilance	analyzing biologic deregulated fkbp11 follicles gep kb lymphoid lymphomas malt malt1 marginal mmp7 mucosa pathologic plasmacytic profiling prominent rara rgs13 signature spiked subgroups subset subsets tending translocations trisomy zone
Tagcloud (Difference) ?		aep amplitudes analgesic analog auditory categorical deteriorated enlarged errors evoked investigates mood morphine n1 neurophysiological oddball p2 pain perceptual potentials rated ratings reflected scales sedation stressor subjective vas vigilance	analyzing biologic deregulated fkbp11 follicles gep kb lymphoid lymphomas malt malt1 marginal mmp7 mucosa pathologic plasmacytic profiling prominent rara rgs13 signature spiked subgroups subset subsets tending translocations trisomy zone
Tagcloud (Intersection) ?