LEP and UCN

Number of citations of the paper that reports this interaction (PMID 12535698)
12

Data Source:
HPRD (in vitro, in vivo)

		LEP	UCN
Gene Name		leptin	urocortin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Dendrite Varicosity Perikaryon Axon Terminus
	Molecular Function	Hormone Activity Growth Factor Activity Peptide Hormone Receptor Binding	Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovulation From Ovarian Follicle Response To Hypoxia Positive Regulation Of Cytokine Production Placenta Development Response To Dietary Excess Glucose Metabolic Process Regulation Of Gluconeogenesis Energy Reserve Metabolic Process Glycerol Biosynthetic Process Fatty Acid Beta-oxidation Tyrosine Phosphorylation Of STAT Protein Female Pregnancy Circadian Rhythm Cholesterol Metabolic Process Bile Acid Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Adult Feeding Behavior Central Nervous System Neuron Development Insulin Secretion Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Appetite Response To Insulin Response To Vitamin E Leptin-mediated Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Bone Mineralization Involved In Bone Maturation Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Glucose Homeostasis Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Ion Transport Positive Regulation Of MAPK Cascade Regulation Of Fat Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Vasoconstriction Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Developmental Growth Regulation Of Insulin Secretion Regulation Of Steroid Biosynthetic Process Leukocyte Tethering Or Rolling Regulation Of Lipoprotein Lipid Oxidation Adipose Tissue Development Negative Regulation Of Cartilage Development Negative Regulation Of Glucagon Secretion Cellular Response To L-ascorbic Acid Cellular Response To Retinoic Acid Positive Regulation Of STAT Protein Import Into Nucleus Negative Regulation Of Glutamine Transport Positive Regulation Of Hepatic Stellate Cell Activation	Inflammatory Response Response To Oxidative Stress G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Associative Learning Aerobic Respiration Negative Regulation Of Gene Expression Pancreatic Juice Secretion Positive Regulation Of Cell Growth Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Histone Deacetylation Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Activation Of Protein Kinase A Activity Social Behavior Gastric Emptying Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Vasodilation Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Necrotic Cell Death Positive Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response
Pathways		Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Signaling by Leptin Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS			Crohn's disease ( 23128233)
Protein-Protein Interactions		10 interactors: A2M CLU CRP GHRL HK3 LEPR PRKAA2 SIGLEC6 STAT3 UCN	4 interactors: CRHBP CRHR1 CRHR2 LEP
Entrez ID		3952	7349
HPRD ID		01249	02970
Ensembl ID		ENSG00000174697
Uniprot IDs		A4D0Y8 P41159	P55089
PDB IDs		1AX8	2RMF 3N96
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Corticotropin Secretion Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Feeding Behavior Response To Organic Substance Generation Of Precursor Metabolites And Energy Negative Regulation Of Cell Death Regulation Of Response To Food Regulation Of Carbohydrate Metabolic Process Regulation Of Appetite Regulation Of Cellular Ketone Metabolic Process Protein Activation Cascade Regulation Of Cytokine Production Regulation Of Glycolytic Process Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Glucose Homeostasis Response To Estrogen Secretion Transport Acute-phase Response Regulation Of Vasodilation Regulation Of Cell Death Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Cellular Metabolic Process Lipid Transport Signaling Lipid Localization Chemical Homeostasis Neurogenesis Negative Regulation Of Hormone Secretion Cell Communication Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Platelet Degranulation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Response To Hormone Acute Inflammatory Response Positive Regulation Of Tau-protein Kinase Activity Cortisol Secretion Regulation Of Neuronal Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Microglial Cell Proliferation Response To External Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion	Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Hormone Secretion Response To Peptide Hormone Response To Peptide Cellular Response To Hormone Stimulus Negative Regulation Of Secretion By Cell Adult Behavior Behavioral Response To Ethanol Response To Organonitrogen Compound Negative Regulation Of Secretion Response To Hormone Female Pregnancy Regulation Of Hormone Secretion Regulation Of Hormone Levels Negative Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of Transport Negative Regulation Of Peptide Secretion Response To Cocaine Single-organism Behavior Cellular Response To Organonitrogen Compound Secretion By Cell Cellular Response To Organic Substance Peptide Hormone Secretion Peptide Secretion Behavior Regulation Of Ion Transport Secretion Hormone Secretion Regulation Of Secretion Hormone Transport Response To Ammonium Ion Regulation Of Lipid Transport Peptide Transport Negative Regulation Of Ion Transport Response To Organic Substance Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Corticotropin Secretion Cellular Response To L-ascorbic Acid Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport General Adaptation Syndrome, Behavioral Process Amide Transport Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Response To Ethanol Regulation Of Ion Transmembrane Transporter Activity Cell-cell Signaling
Tagcloud ?		aep amplitudes analgesic analog auditory categorical deteriorated enlarged errors evoked investigates mood morphine n1 neurophysiological oddball p2 pain perceptual potentials rated ratings reflected scales sedation stressor subjective vas vigilance	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 ucn3 urocortins vasodilation
Tagcloud (Difference) ?		aep amplitudes analgesic analog auditory categorical deteriorated enlarged errors evoked investigates mood morphine n1 neurophysiological oddball p2 pain perceptual potentials rated ratings reflected scales sedation stressor subjective vas vigilance	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 ucn3 urocortins vasodilation
Tagcloud (Intersection) ?