S100A6 and FLT3LG

Number of citations of the paper that reports this interaction (PubMedID 37759746)
234

Data Source:
BioGRID (pull down)

		S100A6	FLT3LG
Description		S100 calcium binding protein A6	fms related receptor tyrosine kinase 3 ligand
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation	Signal Transduction Positive Regulation Of Cell Population Proliferation B Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Embryonic Hemopoiesis Dendritic Cell Differentiation
Pathways			PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)	Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53	5 interacting genes: FLT3 KITLG KRTAP5-9 PFN2 S100A6
Entrez ID		6277	2323
HPRD ID		00237	02477
Ensembl ID		ENSG00000197956	ENSG00000090554
Uniprot IDs		P06703	B7ZLY4 P49771
PDB IDs		1K8U 1K96 1K9K 1K9P 2M1K 4YBH	1ETE 3QS7 3QS9 7NBI 7QDP 7ZV9
Enriched GO Terms of Interacting Partners?		Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation	Positive Regulation Of Cell Population Proliferation Lymphocyte Proliferation Leukocyte Proliferation Hematopoietic Progenitor Cell Differentiation Vascular Endothelial Growth Factor Receptor Activity Positive Regulation Of Phosphorylation Common Myeloid Progenitor Cell Proliferation Pro-B Cell Differentiation Myeloid Progenitor Cell Differentiation Mononuclear Cell Proliferation Phosphatidylinositol 3-kinase Activator Activity Hemopoiesis Positive Regulation Of Protein Phosphorylation Mast Cell Apoptotic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Melanocyte Migration Mast Cell Proliferation Mast Cell Migration Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Stem Cell Factor Receptor Binding Positive Regulation Of Melanocyte Differentiation Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Developmental Pigmentation Regulation Of Mast Cell Proliferation Positive Regulation Of Hematopoietic Stem Cell Proliferation Lymphoid Progenitor Cell Differentiation Positive Regulation Of Phosphate Metabolic Process Modification Of Postsynaptic Actin Cytoskeleton Monoatomic Ion Transmembrane Transporter Activity Regulation Of Developmental Pigmentation Tropomyosin Binding Nuclear Glucocorticoid Receptor Binding S100 Protein Binding Leukocyte Differentiation Positive Regulation Of Protein Modification Process Myeloid Cell Apoptotic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Protein Phosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Phosphorylation Modification Of Postsynaptic Structure
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?