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LEP and GHRL
Number of citations of the paper that reports this interaction (PubMedID
11196643
)
0
Data Source:
HPRD
(in vivo)
LEP
GHRL
Description
leptin
ghrelin and obestatin prepropeptide
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Cytosol
Extracellular Region
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Axon
Secretory Granule Lumen
Schaffer Collateral - CA1 Synapse
Postsynapse
Glutamatergic Synapse
Neuronal Dense Core Vesicle Lumen
Molecular Function
DNA Binding
Signaling Receptor Binding
Hormone Activity
Protein Binding
Peptide Hormone Receptor Binding
Leptin Receptor Binding
G Protein-coupled Receptor Binding
Hormone Activity
Protein Binding
Growth Hormone-releasing Hormone Activity
Protein Tyrosine Kinase Activator Activity
Ghrelin Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Ovulation From Ovarian Follicle
Response To Hypoxia
Positive Regulation Of Cytokine Production
Placenta Development
Regulation Of Endothelial Cell Proliferation
Response To Dietary Excess
Cardiac Muscle Hypertrophy
Glucose Metabolic Process
Regulation Of Gluconeogenesis
Energy Reserve Metabolic Process
Glycerol Biosynthetic Process
Lipid Metabolic Process
Fatty Acid Beta-oxidation
Phagocytosis
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Response To Nutrient
Circadian Rhythm
Cholesterol Metabolic Process
Bile Acid Metabolic Process
Regulation Of Blood Pressure
Positive Regulation Of Cell Population Proliferation
Determination Of Adult Lifespan
Adult Feeding Behavior
Fatty Acid Catabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Autophagy
Negative Regulation Of Lipid Storage
Response To Activity
Regulation Of Metabolic Process
Sexual Reproduction
Central Nervous System Neuron Development
Insulin Secretion
T Cell Differentiation
Regulation Of Intestinal Cholesterol Absorption
Response To Nutrient Levels
Positive Regulation Of TOR Signaling
Negative Regulation Of Appetite
Prostaglandin Secretion
Response To Estradiol
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Natural Killer Cell Activation
Regulation Of Natural Killer Cell Proliferation
Response To Insulin
Cellular Response To Insulin Stimulus
Response To Vitamin E
Leptin-mediated Signaling Pathway
Positive Regulation Of Luteinizing Hormone Secretion
Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Intracellular Signal Transduction
Bone Mineralization Involved In Bone Maturation
Aorta Development
Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Protein Import Into Nucleus
Hormone Metabolic Process
Glucose Homeostasis
Eating Behavior
Negative Regulation Of Apoptotic Process
Positive Regulation Of Monoatomic Ion Transport
Positive Regulation Of MAPK Cascade
Cellular Response To Leptin Stimulus
Response To Ethanol
Regulation Of Fat Cell Differentiation
Regulation Of Angiogenesis
Negative Regulation Of Vasoconstriction
Negative Regulation Of D-glucose Import
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Bone Remodeling
Positive Regulation Of Follicle-stimulating Hormone Secretion
Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Developmental Growth
Regulation Of Insulin Secretion
Regulation Of Steroid Biosynthetic Process
Intestinal Absorption
Leukocyte Tethering Or Rolling
Regulation Of Nitric-oxide Synthase Activity
Negative Regulation Of Transport
Elastin Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Lipoprotein Lipid Oxidation
Adipose Tissue Development
Negative Regulation Of Cartilage Development
Negative Regulation Of Glucagon Secretion
Cellular Response To L-ascorbic Acid
Cellular Response To Retinoic Acid
Regulation Of Brown Fat Cell Differentiation
Energy Homeostasis
Cell Surface Receptor Signaling Pathway Via STAT
Bone Growth
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Protein Localization To Nucleus
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Fat Cell Apoptotic Process
Activation Of Protein Kinase C Activity
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Glutamine Transport
Positive Regulation Of Hepatic Stellate Cell Activation
Gastric Acid Secretion
Negative Regulation Of Endothelial Cell Proliferation
G Protein-coupled Receptor Internalization
Glucose Metabolic Process
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Synapse Assembly
Actin Polymerization Or Depolymerization
Adult Feeding Behavior
Response To Hormone
Hormone-mediated Signaling Pathway
Dendrite Development
Negative Regulation Of Angiogenesis
Growth Hormone Secretion
Response To Nutrient Levels
Positive Regulation Of Insulin Secretion
Regulation Of Response To Food
Positive Regulation Of Response To Food
Positive Regulation Of Appetite
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Growth Rate
Negative Regulation Of Locomotion
Positive Regulation Of Multicellular Organism Growth
Regulation Of Cell Population Proliferation
Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep
Negative Regulation Of Apoptotic Process
Cortisol Secretion
Positive Regulation Of MAPK Cascade
Response To Estrogen
Positive Regulation Of Growth
Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
Negative Regulation Of Insulin Secretion
Decidualization
Negative Regulation Of Inflammatory Response
Cartilage Development
Positive Regulation Of Corticotropin Secretion
Positive Regulation Of Cortisol Secretion
Response To Electrical Stimulus
Positive Regulation Of Synapse Assembly
Regulation Of Transmission Of Nerve Impulse
Excitatory Postsynaptic Potential
Positive Regulation Of Growth Hormone Secretion
Positive Regulation Of Growth Hormone Receptor Signaling Pathway
Postsynaptic Modulation Of Chemical Synaptic Transmission
Regulation Of Postsynapse Organization
Positive Regulation Of Small Intestinal Transit
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Bone Development
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Eating Behavior
Positive Regulation Of Adipose Tissue Development
Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction
Positive Regulation Of Gastric Mucosal Blood Circulation
Positive Regulation Of Small Intestine Smooth Muscle Contraction
Regulation Of Gastric Motility
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Feeding Behavior
Pathways
Signaling by Leptin
Transcriptional regulation of white adipocyte differentiation
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS
BMI at 1.5 years old (
31575865
)
BMI at 8 months old (
31575865
)
Body size at age 10 (
32376654
)
circulating leptin levels (
26833098
32917775
)
circulating leptin levels adjusted for BMI (
26833098
32917775
)
High density lipoprotein cholesterol levels (
29403010
)
Interleukin-6 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction (
34025683
)
Type 2 diabetes (
23945395
26818947
32499647
)
Autism spectrum disorder or schizophrenia (
28540026
)
ghrelin levels (
33852427
)
Interacting Genes
12 interacting genes:
A2M
CLU
CRP
GHRL
HK3
HSF2BP
LEPR
PRKAA2
S100A6
S100P
SIGLEC6
UCN
9 interacting genes:
ACE2
AGRP
GHRHR
GHSR
LEP
MLNR
NPY
UBQLN1
UBQLN2
Entrez ID
3952
51738
HPRD ID
01249
05638
Ensembl ID
ENSG00000174697
ENSG00000157017
Uniprot IDs
A4D0Y8
P41159
Q9UBU3
PDB IDs
1AX8
7Z3Q
8AVE
8AVF
8AVO
8K6Z
8X80
8X81
8X85
6H3E
7F9Y
7NA7
7W2Z
Enriched GO Terms of Interacting Partners
?
Extracellular Region
Regulation Of Feeding Behavior
Positive Regulation Of Corticotropin Secretion
Regulation Of Corticotropin Secretion
Calcium-dependent Protein Binding
Regulation Of Behavior
Negative Regulation Of Complement Activation
Secretory Granule Lumen
Regulation Of Response To Food
Glucose Metabolic Process
Regulation Of Complement Activation
Regulation Of Appetite
Low-density Lipoprotein Particle Receptor Binding
Glial Cell Proliferation
Hexose Metabolic Process
Positive Regulation Of Behavior
Monosaccharide Metabolic Process
Regulation Of Response To Nutrient Levels
Carbohydrate Homeostasis
Glucose Homeostasis
Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Humoral Immune Response
Perinuclear Endoplasmic Reticulum Lumen
Regulation Of Neuronal Signal Transduction
Leptin Receptor Activity
Response To Hormone
Positive Regulation Of Muscle Contraction
Ghrelin Receptor Binding
Cortisol Secretion
Positive Regulation Of Gastric Mucosal Blood Circulation
Protein Localization To Lysosome
Vascular Process In Circulatory System
Platelet Alpha Granule Lumen
Negative Regulation Of Complement Activation, Lectin Pathway
Positive Regulation Of Neurofibrillary Tangle Assembly
Circulatory System Process
Generation Of Precursor Metabolites And Energy
Energy Homeostasis
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Histone H2BS36 Kinase Activity
Negative Regulation Of Hormone Secretion
G Protein-coupled Receptor Binding
Histone Deacetylase Inhibitor Activity
Growth Hormone-releasing Hormone Activity
Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep
Positive Regulation Of Small Intestinal Transit
Positive Regulation Of Growth Rate
Feeding Behavior
Interleukin-8 Binding
Regulation Of Cytokine Production
Adult Feeding Behavior
Feeding Behavior
Positive Regulation Of Behavior
Positive Regulation Of Feeding Behavior
Regulation Of Behavior
Regulation Of Response To Food
Regulation Of Appetite
Regulation Of Feeding Behavior
Growth Hormone-releasing Hormone Receptor Activity
Regulation Of Response To Nutrient Levels
Adult Behavior
Positive Regulation Of Eating Behavior
Positive Regulation Of Response To Food
Positive Regulation Of Appetite
Response To Insulin
Growth Hormone Secretion
Regulation Of Eating Behavior
Peptide Hormone Secretion
Regulation Of Transport
Peptide Secretion
Regulation Of Amine Transport
Hormone Secretion
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Appetite
Response To Peptide Hormone
Regulation Of Growth Hormone Secretion
Cellular Response To Insulin Stimulus
Peptide Transport
Hormone Transport
Hormone Binding
Positive Regulation Of ERAD Pathway
G Protein-coupled Receptor Activity
G Protein-coupled Receptor Signaling Pathway
Amide Transport
Regulation Of Defense Response
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Transport
Regulation Of ERAD Pathway
Signal Release
Positive Regulation Of Developmental Growth
Photoperiodism
Regulation Of Blood Pressure
Neuropeptide Hormone Activity
Cellular Response To Peptide Hormone Stimulus
Eating Behavior
Maternal Process Involved In Female Pregnancy
Positive Regulation Of Multicellular Organism Growth
Hormone Metabolic Process
Determination Of Adult Lifespan
Positive Regulation Of Multicellular Organismal Process
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