LBP and BAG6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LBP	BAG6
Description		lipopolysaccharide binding protein	BAG cochaperone 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Membrane Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome BAT3 Complex
	Molecular Function	Lipopolysaccharide Binding Signaling Receptor Binding Protein Binding Lipid Binding Coreceptor Activity Lipoteichoic Acid Binding Lipopeptide Binding	Signaling Receptor Binding Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ribosome Binding Receptor Ligand Activity Misfolded Protein Binding Molecular Adaptor Activity Proteasome Binding Protein Carrier Chaperone Ubiquitin-specific Protease Binding
	Biological Process	Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Lipid Transport Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis	Kidney Development Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Apoptotic Process Synaptonemal Complex Assembly Spermatogenesis Brain Development Proteasomal Protein Catabolic Process Internal Peptidyl-lysine Acetylation Natural Killer Cell Activation Cell Differentiation Lung Development Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway Maintenance Of Unfolded Protein Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Embryonic Development Protein Stabilization NK T Cell Activation Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway
Pathways		Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Periodontitis (DPAL) ( 24024966)	A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 23894747) Small cell lung carcinoma ( 28604730) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 FTH1 HSPB1 PRDX4 PSMA3 PYCR3 RPS21 SETD1A SMAD3 TRA2A TSC22D4	120 interacting genes: ACVR1B AKT1 AMFR AMTN ANTKMT ANXA7 APBB1IP ARPC3 ATN1 ATXN2 B2M BCL2 C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CDSN CEBPA CHN2 CILK1 CLU CRIPTO CSNK2B CSTF2 CTAG1A CTAG1B CTCFL CTSB CTSE CTSL CXCL8 CYSRT1 DMKN DNAJB11 DPT DRC9 EDN1 EFEMP1 EFEMP2 ELP1 EP300 FAM9B FAS FKBP2 FZD4 GADD45A GLRA2 GOLGA6L9 GSK3B HSPA13 HSPA8 IGF2 IGFBP5 IMMT KLHL12 KPNA2 LBP MAP1LC3B MAPK6 MECOM MEST MTNR1A MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 PLPP2 PLPPR3 POLR2J PRKAR1B PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SERPINI2 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TENT5A TFCP2 TK1 TOMM20 TP53 TP63 TTR UBL7 UBQLN1 UBQLN2 UBQLN4 VAMP2 XRN1 ZFYVE9
Entrez ID		3929	7917
HPRD ID		07175	00808
Ensembl ID		ENSG00000129988	ENSG00000204463
Uniprot IDs		P18428 Q8TCF0	A0A1U9X7A6 A0A7P0MQS5 P46379
PDB IDs			1WX9 2N9P 4DWF 4EEW 4WWR 4X86 6AU8 7RU9 7RUA 7RUC
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Immune Response Immune System Process Positive Regulation Of Interleukin-1 Production Cytolysis By Host Of Symbiont Cells Positive Regulation Of Interleukin-1 Beta Production Extracellular Region Extracellular Exosome Regulation Of Immune System Process Humoral Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Adrenal Gland Development Blood Microparticle Identical Protein Binding Regulation Of Immune Response Killing By Host Of Symbiont Cells Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Response To Other Organism Response To Stress Activation Of Immune Response Lipopolysaccharide Binding Regulation Of Tumor Necrosis Factor Production Prostaglandin Production Involved In Inflammatory Response Biological Process Involved In Interaction With Symbiont Opsonin Receptor Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Humoral Immune Response Positive Regulation Of Stress Fiber Assembly Regulation Of Chemotaxis Tertiary Granule Lumen Regulation Of Cytokine Production Regulation Of Defense Response Protein Stabilization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Cell-substrate Adhesion Complement Activation Positive Regulation Of Cytokine Production Cellular Response To Butyrate Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Interleukin-8 Production Ferritin Complex Iron Ion Sequestering Activity Proteasome Complex	Regulation Of Cellular Response To Stress Extracellular Space Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Extracellular Region Protein Binding Membrane Organization Receptor Ligand Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Endoplasmic Reticulum Stress Signal Transduction Response To Hormone Negative Regulation Of Proteolysis Extracellular Matrix Negative Regulation Of Cellular Component Organization Response To Lipid Tissue Development Regulation Of Protein Catabolic Process Tau Protein Binding Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Leukocyte Apoptotic Process Positive Regulation Of Neutrophil Chemotaxis Regulation Of Ossification G1/S Transition Of Mitotic Cell Cycle Protein-containing Complex Establishment Of Protein Localization To Organelle Molecular Function Activator Activity Cell Cycle G1/S Phase Transition Negative Regulation Of Developmental Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Multicellular Organismal Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Migration Regulation Of Developmental Process Response To Nutrient Levels Cellular Response To Oxygen-containing Compound Endoplasmic Reticulum Lumen T Cell Apoptotic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Signal Transduction
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