LBP and C4BPA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LBP	C4BPA
Gene Name		lipopolysaccharide binding protein	complement component 4 binding protein, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Other Organism Cell Blood Microparticle
	Molecular Function	Lipopolysaccharide Binding Receptor Binding Protein Binding Lipoteichoic Acid Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Toll-like Receptor Signaling Pathway Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Activation Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis	Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Innate Immune System	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS			C4b binding protein levels ( 20212171)
Protein-Protein Interactions		19 interactors: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 FTH1 HSPB1 IRF6 PRDX4 PSMA3 PYCRL RPS21 SETD1A SMAD3 TRA2A TSC22D4	9 interactors: APCS BMPR2 FXYD6 GIT2 GTF2I LBP LRP1 PROS1 SMARCD1
Entrez ID		3929	722
HPRD ID		07175	00403
Ensembl ID		ENSG00000129988	ENSG00000123838
Uniprot IDs		P18428 Q8TCF0	P04003 Q5VVQ8
PDB IDs			2A55 4B0F
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response Regulation Of Interleukin-1 Beta Production Regulation Of Cell Proliferation Humoral Immune Response Protein Stabilization Response To Stress Regulation Of Protein Stability Positive Regulation Of Interleukin-1 Beta Production Regulation Of Protein Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Immune System Process Posttranscriptional Regulation Of Gene Expression Regulation Of Immune Response Positive Regulation Of Stress Fiber Assembly Response To Stimulus Negative Regulation Of Protein Metabolic Process Positive Regulation Of Actin Filament Bundle Assembly Gene Expression Regulation Of Cytokine Production Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Growth Of Symbiont On Or Near Host Surface Regulation Of Protein Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production I-kappaB Kinase/NF-kappaB Signaling Cell Cycle Process Regulation Of Stress Fiber Assembly Regulation Of Inflammatory Response Negative Regulation Of Cell Proliferation Regulation Of Opsonization Intracellular Sequestering Of Iron Ion Negative Regulation Of Interleukin-1 Beta Secretion Sister Chromatid Biorientation Response To Other Organism Positive Regulation Of Protein Metabolic Process Epithelial Cell Proliferation Intracellular Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of Male Germ Cell Proliferation Evasion Or Tolerance Of Host Defenses By Virus Response To Biotic Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Metabolic Process Negative Regulation Of Inflammatory Response	Regulation Of Locomotion Acute-phase Response Regulation Of Inflammatory Response Artery Development Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Acute Inflammatory Response Beta-amyloid Clearance Regulation Of Metabolic Process Positive Regulation Of Chemotaxis Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Regulation Of Lung Blood Pressure Lipopolysaccharide Transport Transition Between Slow And Fast Fiber Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Behavior Regulation Of Wound Healing Negative Regulation Of Vasoconstriction Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis Regulation Of Cell Motility Regulation Of Cellular Component Movement Regulation Of Behavior Negative Regulation Of Monocyte Differentiation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Respiratory Burst Leukocyte Migration Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Skeletal Muscle Adaptation Lymphatic Endothelial Cell Differentiation Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Growth Negative Regulation Of Locomotion Phagocytosis Chromatin-mediated Maintenance Of Transcription Opsonization Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Regulation Of Phospholipase A2 Activity Positive Regulation Of Macrophage Activation Lymphangiogenesis Response To Stress Positive Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Glycoprotein Metabolic Process
Tagcloud ?		adopt af agonists allowing apo bms614 competent constitutive corepressor der disabled disrupts h11 heterodimerization heterodimers holo maintains modelling ngfi pocket relieve rxr rxralpha rxralphaf318a shifting thermodynamic transcriptionally van waals
Tagcloud (Difference) ?		adopt af agonists allowing apo bms614 competent constitutive corepressor der disabled disrupts h11 heterodimerization heterodimers holo maintains modelling ngfi pocket relieve rxr rxralpha rxralphaf318a shifting thermodynamic transcriptionally van waals
Tagcloud (Intersection) ?