LBP and BST1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LBP	BST1
Description		lipopolysaccharide binding protein	bone marrow stromal cell antigen 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Membrane Extracellular Exosome	Uropod Extracellular Region Plasma Membrane Membrane Specific Granule Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	Lipopolysaccharide Binding Signaling Receptor Binding Protein Binding Lipid Binding Coreceptor Activity Lipoteichoic Acid Binding Lipopeptide Binding	Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Phosphorus-oxygen Lyase Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Lipid Transport Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis	Regulation Of Cell-matrix Adhesion Regulation Of Cellular Extravasation Humoral Immune Response Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of B Cell Proliferation Regulation Of Actin Cytoskeleton Organization Regulation Of Inflammatory Response Regulation Of Calcium-mediated Signaling Regulation Of Neutrophil Chemotaxis Regulation Of Superoxide Metabolic Process Regulation Of Integrin-mediated Signaling Pathway
Pathways		Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling	Post-translational modification: synthesis of GPI-anchored proteins Nicotinate metabolism Neutrophil degranulation
Drugs			Etheno-NAD Nicotinamide Adenosine 5'-[gamma-thio]triphosphate Nicotinamide Mononucleotide Etheno-Nadp
Diseases
GWAS		Basophil percentage of white cells ( 32888494) Periodontitis (DPAL) ( 24024966)	Blood protein levels ( 30072576) Current cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Parkinson's disease ( 19915576 21084426 21292315 22451204 25064009 27182965 32201043 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to beta blocker use in hypertension (systolic blood pressure) ( 31423876) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		18 interacting genes: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 FTH1 HSPB1 PRDX4 PSMA3 PYCR3 RPS21 SETD1A SMAD3 TRA2A TSC22D4	2 interacting genes: CAV1 LBP
Entrez ID		3929	683
HPRD ID		07175	02665
Ensembl ID		ENSG00000129988	ENSG00000109743
Uniprot IDs		P18428 Q8TCF0	Q10588
PDB IDs			1ISF 1ISG 1ISH 1ISI 1ISJ 1ISM
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Immune Response Immune System Process Positive Regulation Of Interleukin-1 Production Cytolysis By Host Of Symbiont Cells Positive Regulation Of Interleukin-1 Beta Production Extracellular Region Extracellular Exosome Regulation Of Immune System Process Humoral Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Adrenal Gland Development Blood Microparticle Identical Protein Binding Regulation Of Immune Response Killing By Host Of Symbiont Cells Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Response To Other Organism Response To Stress Activation Of Immune Response Lipopolysaccharide Binding Regulation Of Tumor Necrosis Factor Production Prostaglandin Production Involved In Inflammatory Response Biological Process Involved In Interaction With Symbiont Opsonin Receptor Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Humoral Immune Response Positive Regulation Of Stress Fiber Assembly Regulation Of Chemotaxis Tertiary Granule Lumen Regulation Of Cytokine Production Regulation Of Defense Response Protein Stabilization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Cell-substrate Adhesion Complement Activation Positive Regulation Of Cytokine Production Cellular Response To Butyrate Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Interleukin-8 Production Ferritin Complex Iron Ion Sequestering Activity Proteasome Complex	Regulation Of Toll-like Receptor 4 Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Inward Rectifier Potassium Channel Inhibitor Activity Innate Immune Response-activating Signaling Pathway Insulin Receptor Internalization Protein Localization To Basolateral Plasma Membrane Intracellular Nitric Oxide Homeostasis Nitric-oxide Synthase Inhibitor Activity Caveolar Macromolecular Signaling Complex Activation Of Innate Immune Response Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Lipopolysaccharide Transport Regulation Of Entry Of Bacterium Into Host Cell Signaling Receptor Binding Peptidase Activator Activity Caveola Assembly Positive Regulation Of Cell Activation Protein Tyrosine Kinase Inhibitor Activity Protein Localization To Plasma Membrane Raft Positive Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Caveolin-mediated Endocytosis Regulation Of Membrane Repolarization During Action Potential Response To Bacterium Protein Localization To Membrane Raft Lipid Transport Regulation Of Gap Junction Assembly Positive Regulation Of Gap Junction Assembly Negative Regulation Of Pinocytosis Mammary Gland Involution Patched Binding Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of The Force Of Heart Contraction By Chemical Signal Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Hyperoxia Immune Response-activating Signaling Pathway Positive Regulation Of Respiratory Burst Lipoteichoic Acid Binding Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Lipopeptide Binding Nitric-oxide Synthase Binding Receptor-mediated Endocytosis Of Virus By Host Cell Plasma Membrane Raft Assembly Regulation Of Innate Immune Response Regulation Of Ventricular Cardiac Muscle Cell Action Potential Immune Response-regulating Signaling Pathway Positive Regulation Of Defense Response
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