LAMA5 and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
HPRD (two hybrid)

		LAMA5	MYOC
Gene Name		laminin, alpha 5	myocilin, trabecular meshwork inducible glucocorticoid response
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Basal Lamina Laminin-1 Complex Laminin-5 Complex Extracellular Space Nucleus Extracellular Matrix Laminin-10 Complex Laminin-11 Complex Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Structural Molecule Activity	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Angiogenesis Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Hair Follicle Development Cytoskeleton Organization Integrin-mediated Signaling Pathway Muscle Organ Development Cell Recognition Cell Proliferation Embryo Development Morphogenesis Of Embryonic Epithelium Cell Migration Extracellular Matrix Disassembly Cell Differentiation Regulation Of Cell Adhesion Extracellular Matrix Organization Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Proliferation Cilium Assembly Odontogenesis Of Dentin-containing Tooth Endothelial Cell Differentiation Regulation Of Embryonic Development Focal Adhesion Assembly Branching Involved In Salivary Gland Morphogenesis Establishment Of Protein Localization To Plasma Membrane	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Colorectal cancer ( 20972440) Prostate cancer ( 23535732)
Protein-Protein Interactions		15 interactors: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 LAMC1 MEP1A MYOC PLAT PLG SMAD2 SV2A USP4	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		3911	4653
HPRD ID		03020	03387
Ensembl ID		ENSG00000130702	ENSG00000034971
Uniprot IDs		O15230	Q99972
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Endoderm Development Extracellular Matrix Disassembly Fibrinolysis Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Myelination In Peripheral Nervous System Schwann Cell Development Negative Regulation Of Cell-substrate Adhesion Endoderm Formation Negative Regulation Of Blood Coagulation Schwann Cell Differentiation Negative Regulation Of Coagulation Nerve Maturation Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Wound Healing Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Calcium-dependent Cell-matrix Adhesion ERBB2 Signaling Pathway Glial Cell Development Regulation Of Blood Coagulation Proteolysis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Ovulation Mononuclear Cell Migration Zygotic Specification Of Dorsal/ventral Axis Peripheral Nervous System Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Cell-substrate Adhesion Regulation Of Protein Kinase B Signaling Formation Of Primary Germ Layer Regulation Of Wound Healing Tissue Development Myelination Regulation Of Cellular Process Positive Regulation Of Mesoderm Development Non-canonical Wnt Signaling Pathway Via JNK Cascade Primary MiRNA Processing Axon Ensheathment Regulation Of Nodal Signaling Pathway Non-canonical Wnt Signaling Pathway Via MAPK Cascade Common-partner SMAD Protein Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Activin Receptor Signaling Pathway	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?		anencephaly aperta arches axd bifida breadth cart1 curly ectoderm exencephaly faulty floorplate folds gja1 jmj macs mlp neuroepithelial neuroepithelium nonsyndromic notochord ntds occulta rachischisis rostro selh spina tcfap2a terc	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?		anencephaly aperta arches axd bifida breadth cart1 curly ectoderm exencephaly faulty floorplate folds gja1 jmj macs mlp neuroepithelial neuroepithelium nonsyndromic notochord ntds occulta rachischisis rostro selh spina tcfap2a terc	accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?