LAMA5 and MEP1A

Number of citations of the paper that reports this interaction (PubMedID 10620696)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		LAMA5	MEP1A
Description		laminin subunit alpha 5	meprin A subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Space Nucleus Extracellular Matrix Neuromuscular Junction Synaptic Cleft Laminin-10 Complex Laminin-11 Complex Extracellular Exosome Extracellular Matrix Of Synaptic Cleft Glutamatergic Synapse	Extracellular Space Plasma Membrane Membrane Meprin A Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Receptor Ligand Activity Cell Adhesion Mediator Activity	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metallodipeptidase Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Kidney Development Hair Follicle Development Cell Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Animal Organ Morphogenesis Morphogenesis Of Embryonic Epithelium Cell Migration Regulation Of Cell Adhesion Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Trunk Neural Crest Cell Migration Odontogenesis Of Dentin-containing Tooth Regulation Of Embryonic Development Skeletal System Morphogenesis System Development Branching Morphogenesis Of An Epithelial Tube Regulation Of Epithelial Cell Proliferation Cilium Assembly Branching Involved In Salivary Gland Morphogenesis Protein Localization To Plasma Membrane Postsynapse Organization	Proteolysis Epidermal Growth Factor Receptor Ligand Maturation Signaling Receptor Ligand Precursor Processing
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs		Lanoteplase
Diseases
GWAS		Colorectal cancer ( 20972440 24737748 25990418) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Neuroblastoma (pediatric) ( 32599975) Pelvic organ prolapse ( 26545240) Plateletcrit ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		16 interacting genes: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 HOXA1 LAMC1 MEP1A MTDH MYOC SMAD2 SV2A UBC USP4	18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP
Entrez ID		3911	4224
HPRD ID		03020	02666
Ensembl ID		ENSG00000130702	ENSG00000112818
Uniprot IDs		O15230	B7ZL91 Q16819
PDB IDs		5XAU 7CEC	7UAB 7UAC 7UAE 7UAF 7UAI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Extracellular Matrix Constituent Conferring Elasticity Basement Membrane Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Myelination In Peripheral Nervous System Node Of Ranvier Laminin Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Cholesterol Extracellular Space Cell-substrate Adhesion Endoderm Development Positive Regulation Of Intracellular Signal Transduction Collagen Type VII Trimer Regulation Of Cell Adhesion RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Attachment Semicircular Canal Formation Skeletal Muscle Hypertrophy Adenosine Receptor Binding Regulation Of Signal Transduction Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Region Endoplasmic Reticulum Lumen Heart Development Helper T Cell Diapedesis Chordate Pharynx Development Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Communication Cerebellar Neuron Development Regulation Of Intracellular Signal Transduction Receptor Tyrosine Kinase Binding Neuromuscular Junction Regulation Of Signaling Response To Transforming Growth Factor Beta Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Positive Regulation Of Cell-matrix Adhesion Calcium-dependent Cell-matrix Adhesion Peptide Hormone Secretion Endothelin B Receptor Binding Peptide Secretion Abducens Nerve Formation	Hormone Activity Extracellular Space Extracellular Region Receptor Ligand Activity Signaling Receptor Binding G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Peptide Hormone Receptor Binding Antifungal Humoral Response Humoral Immune Response Regulation Of Hormone Secretion Regulation Of Signaling Regulation Of Multicellular Organismal Process Response To Yeast Regulation Of Hormone Levels Negative Regulation Of Multicellular Organismal Process Regulation Of Secretion By Cell Regulation Of Biological Quality Cell-cell Signaling Regulation Of Secretion Signaling Regulation Of Appetite Cell Communication Regulation Of Cell Communication Extracellular Matrix Blood Microparticle Killing Of Cells Of Another Organism Regulation Of Cell Adhesion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Cell Population Proliferation Regulation Of Corticosterone Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Defense Response To Fungus Response To External Biotic Stimulus Regulation Of Blood Pressure Response To Hormone Defense Response Regulation Of Cell Migration Response To Fungus Antibacterial Humoral Response Cell Killing Platelet Alpha Granule Lumen
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