LAMA5 and FBLN2

Number of citations of the paper that reports this interaction (PMID 9006922)
12

Data Source:
HPRD (in vitro, in vivo)

		LAMA5	FBLN2
Gene Name		laminin, alpha 5	fibulin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Basal Lamina Laminin-1 Complex Laminin-5 Complex Extracellular Space Nucleus Extracellular Matrix Laminin-10 Complex Laminin-11 Complex Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix Vesicle Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Structural Molecule Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Binding
	Biological Process	Angiogenesis Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Hair Follicle Development Cytoskeleton Organization Integrin-mediated Signaling Pathway Muscle Organ Development Cell Recognition Cell Proliferation Embryo Development Morphogenesis Of Embryonic Epithelium Cell Migration Extracellular Matrix Disassembly Cell Differentiation Regulation Of Cell Adhesion Extracellular Matrix Organization Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Proliferation Cilium Assembly Odontogenesis Of Dentin-containing Tooth Endothelial Cell Differentiation Regulation Of Embryonic Development Focal Adhesion Assembly Branching Involved In Salivary Gland Morphogenesis Establishment Of Protein Localization To Plasma Membrane	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization
Pathways		Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions Degradation of the extracellular matrix	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Colorectal cancer ( 20972440) Prostate cancer ( 23535732)	Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		15 interactors: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 LAMC1 MEP1A MYOC PLAT PLG SMAD2 SV2A USP4	22 interactors: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ELN FBN1 FN1 HSPG2 ITGB3 LAMA1 LAMA5 LAMC2 NID1 PRELP VCAN ZNF408
Entrez ID		3911	2199
HPRD ID		03020	00630
Ensembl ID		ENSG00000130702	ENSG00000163520
Uniprot IDs		O15230	F5H1F3 P98095 Q86V58 Q9Y3V7
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Endoderm Development Extracellular Matrix Disassembly Fibrinolysis Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Myelination In Peripheral Nervous System Schwann Cell Development Negative Regulation Of Cell-substrate Adhesion Endoderm Formation Negative Regulation Of Blood Coagulation Schwann Cell Differentiation Negative Regulation Of Coagulation Nerve Maturation Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Wound Healing Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Calcium-dependent Cell-matrix Adhesion ERBB2 Signaling Pathway Glial Cell Development Regulation Of Blood Coagulation Proteolysis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Ovulation Mononuclear Cell Migration Zygotic Specification Of Dorsal/ventral Axis Peripheral Nervous System Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Cell-substrate Adhesion Regulation Of Protein Kinase B Signaling Formation Of Primary Germ Layer Regulation Of Wound Healing Tissue Development Myelination Regulation Of Cellular Process Positive Regulation Of Mesoderm Development Non-canonical Wnt Signaling Pathway Via JNK Cascade Primary MiRNA Processing Axon Ensheathment Regulation Of Nodal Signaling Pathway Non-canonical Wnt Signaling Pathway Via MAPK Cascade Common-partner SMAD Protein Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Activin Receptor Signaling Pathway	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development System Development Developmental Process Multicellular Organismal Development Cell Adhesion Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Catabolic Process Cardiovascular System Development Blood Vessel Morphogenesis Locomotion Catabolic Process Blood Vessel Development Cell Morphogenesis Nervous System Development Angiogenesis Vasculature Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Axon Guidance Tissue Development Cell-substrate Junction Assembly Cell Development Organ Development Axonogenesis Glomerular Basement Membrane Development Renal System Development Cell Projection Morphogenesis Glycosaminoglycan Metabolic Process Axon Development Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Urogenital System Development Pathogenesis Neuron Projection Morphogenesis Cell Differentiation Proteoglycan Metabolic Process Cell Projection Organization Neuron Projection Development Retinal Blood Vessel Morphogenesis Kidney Development Neurogenesis
Tagcloud ?		anencephaly aperta arches axd bifida breadth cart1 curly ectoderm exencephaly faulty floorplate folds gja1 jmj macs mlp neuroepithelial neuroepithelium nonsyndromic notochord ntds occulta rachischisis rostro selh spina tcfap2a terc	3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing
Tagcloud (Difference) ?		anencephaly aperta arches axd bifida breadth cart1 curly ectoderm exencephaly faulty floorplate folds gja1 jmj macs mlp neuroepithelial neuroepithelium nonsyndromic notochord ntds occulta rachischisis rostro selh spina tcfap2a terc	3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing
Tagcloud (Intersection) ?