LAMA5 and BCAM

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, in vivo)

		LAMA5	BCAM
Name		laminin subunit alpha 5	basal cell adhesion molecule (Lutheran blood group)
Structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Space Nucleus Extracellular Matrix Neuromuscular Junction Synaptic Cleft Laminin-10 Complex Laminin-11 Complex Extracellular Exosome Extracellular Matrix Of Synaptic Cleft Glutamatergic Synapse	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Receptor Ligand Activity Cell Adhesion Mediator Activity	Transmembrane Signaling Receptor Activity Laminin Receptor Activity Protein Binding Laminin Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Kidney Development Hair Follicle Development Cell Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Animal Organ Morphogenesis Morphogenesis Of Embryonic Epithelium Cell Migration Regulation Of Cell Adhesion Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Trunk Neural Crest Cell Migration Odontogenesis Of Dentin-containing Tooth Regulation Of Embryonic Development Skeletal System Morphogenesis System Development Branching Morphogenesis Of An Epithelial Tube Regulation Of Epithelial Cell Proliferation Cilium Assembly Branching Involved In Salivary Gland Morphogenesis Protein Localization To Plasma Membrane Postsynapse Organization	Angiogenesis Cell Adhesion Cell-matrix Adhesion Signal Transduction
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	None
Drugs		Lanoteplase	None
GWAS		Colorectal cancer ( 20972440 24737748 25990418 ) Colorectal cancer or advanced adenoma ( 30510241 ) Estimated glomerular filtration rate ( 31152163 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Neuroblastoma (pediatric) ( 32599975 ) Pelvic organ prolapse ( 26545240 ) Plateletcrit ( 32888494 ) Prostate cancer ( 23535732 )	Alzheimer's disease ( 24755620 30636644 ) Alzheimer's disease (onset between ages 58 and 79) ( 30979435 ) Alzheimer's disease in hypertension ( 31055733 ) Alzheimer's disease in hypertension-negative individuals ( 31055733 ) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Blood protein levels ( 30072576 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Carotid intima media thickness (maximum) ( 31801372 ) Carotid intima media thickness (mean) ( 31801372 ) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321 ) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321 ) Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Cerebrospinal fluid AB1-42 levels ( 28247064 29274321 ) Cerebrospinal fluid p-tau levels ( 29274321 ) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321 ) Cerebrospinal fluid t-tau levels ( 29274321 ) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321 ) Hippocampal volume ( 29274321 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) LDL cholesterol ( 30275531 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Logical memory (delayed recall) ( 29274321 ) Logical memory (immediate recall) ( 29274321 ) Waist-to-hip circumference ratio (smoking years interaction) ( 23192594 )
Novel Interactors		1 novel interactors: EDN3	None recorded
Interacting Genes		16 interacting genes: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 HOXA1 LAMC1 MEP1A MTDH MYOC SMAD2 SV2A UBC USP4	10 interacting genes: EPB41 KLHL2 KRTAP1-1 KRTAP1-3 LAMA5 MDFI NBPF19 NOTCH2NLA TRIM7 UBE2I
Entrez ID		3911	4059
HPRD ID		03020	00197
Ensembl ID		ENSG00000130702	ENSG00000187244
Uniprot IDs		O15230	A0A087WXM8 P50895
PDB IDs		5XAU 7CEC	2PET 2PF6
GO Terms Enriched among Interactors		Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Extracellular Matrix Constituent Conferring Elasticity Basement Membrane Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Myelination In Peripheral Nervous System Node Of Ranvier Laminin Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Cholesterol Extracellular Space Cell-substrate Adhesion Endoderm Development Positive Regulation Of Intracellular Signal Transduction Collagen Type VII Trimer Regulation Of Cell Adhesion RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Attachment Semicircular Canal Formation Skeletal Muscle Hypertrophy Adenosine Receptor Binding Regulation Of Signal Transduction Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Region Endoplasmic Reticulum Lumen Heart Development Helper T Cell Diapedesis Chordate Pharynx Development Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Communication Cerebellar Neuron Development Regulation Of Intracellular Signal Transduction Receptor Tyrosine Kinase Binding Neuromuscular Junction Regulation Of Signaling Response To Transforming Growth Factor Beta Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Positive Regulation Of Cell-matrix Adhesion Calcium-dependent Cell-matrix Adhesion Peptide Hormone Secretion Endothelin B Receptor Binding Peptide Secretion Abducens Nerve Formation	None