LAMA5 and BCAM

Number of citations of the paper that reports this interaction (PMID 12244066)
16

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo, in vitro)

		LAMA5	BCAM
Gene Name		laminin, alpha 5	basal cell adhesion molecule (Lutheran blood group)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Basal Lamina Laminin-1 Complex Laminin-5 Complex Extracellular Space Nucleus Extracellular Matrix Laminin-10 Complex Laminin-11 Complex Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Structural Molecule Activity	Transmembrane Signaling Receptor Activity Laminin Receptor Activity Laminin Binding
	Biological Process	Angiogenesis Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Hair Follicle Development Cytoskeleton Organization Integrin-mediated Signaling Pathway Muscle Organ Development Cell Recognition Cell Proliferation Embryo Development Morphogenesis Of Embryonic Epithelium Cell Migration Extracellular Matrix Disassembly Cell Differentiation Regulation Of Cell Adhesion Extracellular Matrix Organization Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Proliferation Cilium Assembly Odontogenesis Of Dentin-containing Tooth Endothelial Cell Differentiation Regulation Of Embryonic Development Focal Adhesion Assembly Branching Involved In Salivary Gland Morphogenesis Establishment Of Protein Localization To Plasma Membrane	Cell Adhesion Cell-matrix Adhesion Signal Transduction
Pathways		Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Colorectal cancer ( 20972440) Prostate cancer ( 23535732)	Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		15 interactors: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 LAMC1 MEP1A MYOC PLAT PLG SMAD2 SV2A USP4	5 interactors: EPB41 KLHL2 LAMA5 SUMO1 UBE2I
Entrez ID		3911	4059
HPRD ID		03020	00197
Ensembl ID		ENSG00000130702	ENSG00000187244
Uniprot IDs		O15230	P50895
PDB IDs			2PET 2PF6
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Endoderm Development Extracellular Matrix Disassembly Fibrinolysis Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Myelination In Peripheral Nervous System Schwann Cell Development Negative Regulation Of Cell-substrate Adhesion Endoderm Formation Negative Regulation Of Blood Coagulation Schwann Cell Differentiation Negative Regulation Of Coagulation Nerve Maturation Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Wound Healing Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Calcium-dependent Cell-matrix Adhesion ERBB2 Signaling Pathway Glial Cell Development Regulation Of Blood Coagulation Proteolysis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Ovulation Mononuclear Cell Migration Zygotic Specification Of Dorsal/ventral Axis Peripheral Nervous System Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Cell-substrate Adhesion Regulation Of Protein Kinase B Signaling Formation Of Primary Germ Layer Regulation Of Wound Healing Tissue Development Myelination Regulation Of Cellular Process Positive Regulation Of Mesoderm Development Non-canonical Wnt Signaling Pathway Via JNK Cascade Primary MiRNA Processing Axon Ensheathment Regulation Of Nodal Signaling Pathway Non-canonical Wnt Signaling Pathway Via MAPK Cascade Common-partner SMAD Protein Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Activin Receptor Signaling Pathway	Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of SUMO Transferase Activity Post-translational Protein Modification PML Body Organization Peptidyl-lysine Modification Regulation Of Binding Protein Localization To Nuclear Pore Protein Localization To Nuclear Envelope Organelle Organization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Localization To Membrane
Tagcloud ?		anencephaly aperta arches axd bifida breadth cart1 curly ectoderm exencephaly faulty floorplate folds gja1 jmj macs mlp neuroepithelial neuroepithelium nonsyndromic notochord ntds occulta rachischisis rostro selh spina tcfap2a terc	adam aureus cdt clostridium cnf1 compartments cytosol difficile effectors endosomal enter laminin lipolysis lipoprotein lrp lsr lu machines metalloprotease necrotizing optimized perfringens protocols retrograde staphylococcus toxin toxins tpel transferase
Tagcloud (Difference) ?		anencephaly aperta arches axd bifida breadth cart1 curly ectoderm exencephaly faulty floorplate folds gja1 jmj macs mlp neuroepithelial neuroepithelium nonsyndromic notochord ntds occulta rachischisis rostro selh spina tcfap2a terc	adam aureus cdt clostridium cnf1 compartments cytosol difficile effectors endosomal enter laminin lipolysis lipoprotein lrp lsr lu machines metalloprotease necrotizing optimized perfringens protocols retrograde staphylococcus toxin toxins tpel transferase
Tagcloud (Intersection) ?