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KRTAP10-5 and SPRY2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
KRTAP10-5
SPRY2
Gene Name
keratin associated protein 10-5
sprouty homolog 2 (Drosophila)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Keratin Filament
Cytosol
Microtubule
Plasma Membrane
Microtubule Cytoskeleton
Ruffle Membrane
Molecular Function
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Biological Process
Establishment Of Mitotic Spindle Orientation
Epidermal Growth Factor Receptor Signaling Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Ras GTPase Activity
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Cell Fate Commitment
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Lung Growth
Bud Elongation Involved In Lung Branching
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Signaling by EGFR
EGFR downregulation
Signaling by FGFR in disease
Signaling by EGFR in Cancer
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Spry regulation of FGF signaling
Signaling by FGFR
Negative regulation of FGFR signaling
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Fasting insulin-related traits (interaction with BMI) (
22581228
)
Orofacial clefts (
20023658
22863734
)
Type 2 diabetes (
20862305
)
Protein-Protein Interactions
108 interactors:
ADAMTSL4
AEN
ALDH3B1
AMOTL2
BCL6B
BMP7
BYSL
C11orf87
C19orf66
C9orf9
CARD9
CHRD
CNNM3
CREB5
DHX57
ECE1
EIF4E2
ENKD1
FAM74A4
FAM76B
FARS2
GATA1
GLIDR
GLRX3
GNE
GOLGA8EP
HHEX
HOXA1
HPCAL1
KRTAP10-3
KRTAP10-7
KRTAP12-1
KRTAP12-2
KRTAP2-4
KRTAP26-1
KRTAP3-2
KRTAP4-12
KRTAP4-2
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LCE1B
LCE2A
LCE2D
LCE3C
LCE3E
LCE4A
LIMS2
LUZP4
MEOX2
MOBP
MT1DP
MXI1
NAA10
NOTCH2NL
NPDC1
NR4A1
NUFIP2
OTX1
POM121L8P
PRKAB2
PRR13
PVRL2
SCNM1
SLC23A1
SLC6A20
SMCP
SPATA3
SPRY1
SPRY2
STK16
TBC1D16
THAP10
TNP2
TNS2
TRPV6
TULP3
TXNDC5
TYMSOS
UTP23
WDYHV1
WT1-AS
ZBTB24
ZBTB48
ZFYVE21
ZNF20
ZNF264
ZNF273
ZNF286A
ZNF32
ZNF320
ZNF329
ZNF34
ZNF417
ZNF433
ZNF439
ZNF559
ZNF572
ZNF587
ZNF670
ZNF679
ZNF697
ZNF707
ZNF785
ZNF792
ZSCAN21
ZSCAN26
90 interactors:
ADAMTSL4
AQP1
ATRIP
C19orf66
CATSPER1
CBL
CBLB
CBLC
CHRD
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
EIF4E2
FAIM
FAM219A
FBN1
FRS3
GNE
GP9
GPRIN2
GRAP2
GRB2
HEXIM2
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1B
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
OTX1
PACSIN3
PLSCR1
PRKAB2
PTGER3
PTPN11
RAF1
RTFDC1
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SIAH2
SPRY1
STK16
TCAF1
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
Entrez ID
386680
10253
HPRD ID
11191
03916
Ensembl ID
ENSG00000136158
Uniprot IDs
P60370
O43597
PDB IDs
3BUM
3OB1
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Metabolic Process
RNA Biosynthetic Process
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Biosynthetic Process
Keratinization
Regulation Of Nitrogen Compound Metabolic Process
Keratinocyte Differentiation
Regulation Of Metabolic Process
Epidermal Cell Differentiation
Epithelium Development
Epidermis Development
Cellular Process
Cellular Metabolic Process
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Skin Development
Tissue Development
Regulation Of Cellular Process
Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Organ Development
Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Chordate Embryonic Development
Embryo Development Ending In Birth Or Egg Hatching
Embryonic Neurocranium Morphogenesis
Penetration Of Zona Pellucida
Embryo Development
Epithelial Cell Differentiation
Epithelial Tube Branching Involved In Lung Morphogenesis
Bud Elongation Involved In Lung Branching
Pattern Specification Process
Embryonic Organ Development
Negative Regulation Of Protein Serine/threonine Kinase Activity
Embryonic Morphogenesis
Lung Morphogenesis
Anterior/posterior Pattern Specification
Respiratory Tube Development
Negative Regulation Of Ras GTPase Activity
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Keratinization
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Signaling
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Process
Keratinocyte Differentiation
Regulation Of Cell Activation
Negative Regulation Of Protein Metabolic Process
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Death
System Development
Death
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cell-cell Adhesion
Developmental Process
Multicellular Organismal Development
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Regulation Of T Cell Activation
Cellular Response To Organic Substance
Cell Differentiation
Anatomical Structure Development
Organ Development
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Kinase Activity
Epidermal Cell Differentiation
Response To Growth Factor
Protein Modification By Small Protein Conjugation
Epithelium Development
Regulation Of Apoptotic Process
Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Kinase Activity
Regulation Of Immune System Process
Negative Regulation Of Cellular Metabolic Process
Tagcloud
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Difference)
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Intersection)
?