KRTAP10-5 and SLC6A20

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRTAP10-5	SLC6A20
Description		keratin associated protein 10-5	solute carrier family 6 member 20
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Proline:sodium Symporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-isoleucine Transmembrane Transporter Activity L-proline Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Transmembrane Transporter Activity
	Biological Process		Amino Acid Transport Glycine Transport Proline Transport Amino-acid Betaine Transport Sodium Ion Transmembrane Transport Amino Acid Import Across Plasma Membrane Transport Across Blood-brain Barrier Glycine Import Across Plasma Membrane L-isoleucine Import Across Plasma Membrane L-proline Import Across Plasma Membrane Proline Import Across Plasma Membrane
Pathways		Keratinization	Amino acid transport across the plasma membrane SLC-mediated transport of neurotransmitters Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)
Drugs
Diseases			Iminoglycinuria
GWAS			Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) COVID-19 ( 33949668) Hirschsprung disease ( 25310821) Immune reponse to smallpox (secreted TNF-alpha) ( 22610502) Macular telangiectasia type 2 ( 33654266) Macular thickness ( 30535121) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary metabolites ( 21572414 26352407)
Interacting Genes		159 interacting genes: ADAMTSL4 AEN ALDH3B1 AMOTL2 BCL6B BMP7 BYSL C11orf87 C17orf50 CARD9 CATSPER1 CHRD CNNM3 CRCT1 CREB5 CYSRT1 DHX57 ECE1 EIF4E2 ENKD1 FAM74A4 FAM76B FARS2 FBXO34 FCHO1 GATA1 GLIDR GLRX3 GNE GOLGA8EP GPRIN2 HHEX HOXA1 HPCAL1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP13-1 KRTAP13-2 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LIMS2 LUZP4 MEOX2 MOBP MT1DP MXI1 NAA10 NBPF19 NECTIN2 NOTCH2NLA NPDC1 NR4A1 NR4A3 NTAQ1 NUFIP2 OTX1 POM121L8P POU4F2 PRKAB2 PRKAG1 PRR13 RBP3 SCNM1 SHFL SLC23A1 SLC6A20 SMCP SPACA9 SPATA3 SPRY1 SPRY2 STK16 TBC1D16 THAP10 TNP2 TNS2 TRIM42 TRPV6 TULP3 TXNDC5 TYMSOS UTP23 WT1 WT1-AS YY1 ZBTB24 ZBTB48 ZFYVE21 ZNF124 ZNF20 ZNF264 ZNF273 ZNF286A ZNF32 ZNF320 ZNF329 ZNF34 ZNF417 ZNF433 ZNF439 ZNF440 ZNF559 ZNF572 ZNF578 ZNF587 ZNF670 ZNF679 ZNF696 ZNF697 ZNF707 ZNF785 ZNF792 ZSCAN21 ZSCAN26	14 interacting genes: ADAMTSL4 CYSRT1 KRTAP1-1 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP5-9 MESD NBPF19 NOTCH2NLA SNCA
Entrez ID		386680	54716
HPRD ID		11191	16128
Ensembl ID		ENSG00000241123	ENSG00000163817
Uniprot IDs		P60370	A0A8V8TQV4 B7ZLW4 Q9NP91
PDB IDs			7Y75 7Y76 8I91 8P2W 8P2X 8P2Y 8P2Z 8P30 8P31 8WM3
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Tissue Development Protein Binding Zinc Ion Binding Hair Cycle DNA Binding Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Glomerular Mesangial Cell Proliferation Sequence-specific Double-stranded DNA Binding	Intermediate Filament Keratin Filament Identical Protein Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Pigment Cell Development
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