KPNA1 and ELAVL1

Number of citations of the paper that reports this interaction (PubMedID 15342649)
0

Data Source:
HPRD (in vivo)

		KPNA1	ELAVL1
Description		karyopherin subunit alpha 1	ELAV like RNA binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite NLS-dependent Protein Nuclear Import Complex Glutamatergic Synapse	P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Sarcoplasm Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity LncRNA Binding
	Biological Process	Regulation Of DNA Recombination Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein Transport Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Canonical Wnt Signaling Pathway Postsynapse To Nucleus Signaling Pathway	LncRNA-mediated Post-transcriptional Gene Silencing Protein Import Into Nucleus Cell Population Proliferation Response To Glucose Positive Regulation Of Autophagy Post-transcriptional Gene Silencing Positive Regulation Of Superoxide Anion Generation Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Autophagosome Size MRNA Stabilization Protein Homooligomerization Negative Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Inhibition of nitric oxide production	HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS		Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		49 interacting genes: ANP32A ANP32B ARNT ATM BCAR3 CDKN1B CENPF CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GNL3L GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP54 NUP62 OGT ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RIPK4 RUNX1T1 SENP2 SF1 SKP2 SLC25A21-AS1 SRP19 STAT1 STAT3 TAF9 UBR5	44 interacting genes: AKT1 ANP32A ANP32B APOE C12orf75 CARM1 CEBPA CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL6 IL7R KPNA1 KPNB1 LINC00460 LINC00632 MIRLET7B MIRLET7I NEIL3 NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SHANK3 SREK1 TNPO1 TNPO2 TRIM21 VCP VEGFA
Entrez ID		3836	1994
HPRD ID		02819	16025
Ensembl ID		ENSG00000114030	ENSG00000066044
Uniprot IDs		P52294	Q15717
PDB IDs		2JDQ 3TJ3 4B18 6WX9	3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Protein Localization To Nucleus Regulation Of Gene Expression Import Into Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Nuclear Pore Intracellular Protein Localization Positive Regulation Of Gene Expression Regulation Of Developmental Process Hsp90 Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Oxidative Stress Establishment Of Protein Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Transcription Corepressor Binding Regulation Of Erythrocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Glycolytic Process V(D)J Recombination	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Import Signal Receptor Activity Regulation Of Signal Transduction Regulation Of Platelet Activation Nuclear Localization Sequence Binding Regulation Of Macromolecule Metabolic Process Stress Granule Disassembly Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Blood Coagulation Positive Regulation Of Catabolic Process Intracellular Signaling Cassette Regulation Of Fat Cell Differentiation Regulation Of Hemostasis Regulation Of Wound Healing Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Response To Wounding Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity
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