KPNA1 and LMO4

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KPNA1	LMO4
Gene Name		karyopherin alpha 1 (importin alpha 5)	LIM domain only 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Dendrite	Transcription Factor Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity	Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Zinc Ion Binding
	Biological Process	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Intracellular Transport Of Virus	Neural Tube Closure Ventricular Septum Development Transcription From RNA Polymerase II Promoter Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Negative Regulation Of Protein Complex Assembly Regulation Of Cell Fate Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Regulation Of Cell Activation
Pathways		Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism HIV Infection Host Interactions of HIV factors Interferon Signaling Apoptotic execution phase Integration of provirus Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Early Phase of HIV Life Cycle Influenza Life Cycle HIV Life Cycle Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death
Drugs
Diseases
GWAS		Calcium levels ( 20705733)	Response to TNF antagonist treatment ( 18615156) White blood cell types ( 21738478)
Protein-Protein Interactions		32 interactors: ANP32A ANP32B BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 FOSL1 GOPC HDAC6 HIST2H2BE HIST3H3 IL1RAP KPNB1 LEF1 LMO4 NOSIP NUP50 NUP54 NUP62 ORC4 PAX5 RAG1 RANBP2 RUNX1T1 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5	53 interactors: AES AMOT AMOTL2 BANP BRCA1 CALCOCO2 CCDC102B CEP170P1 CSNK2B DDB1 DEAF1 ERCC6L GABPB1 GADD45A GOLGA2 GRHL2 GSK3B ITSN1 KANK2 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT40 LDB1 LDB2 MERTK MTA1 NFYC NHLH1 NONO PDE4DIP PITPNB PLK1 PPARG RBBP8 RBPMS RPS6KA6 SEC24D SMAD4 SMAD9 TCF21 TCF4 TFIP11 TINAGL1 TNFSF11 TP53BP2 TSEN15 VPS52 ZBTB43 ZNF397 ZNF675
Entrez ID		3836	8543
HPRD ID		02819	09122
Ensembl ID		ENSG00000114030	ENSG00000143013
Uniprot IDs		B3KXZ2 P52294	P61968
PDB IDs		2JDQ 3TJ3 4B18	2L4Z
Enriched GO Terms of Interacting Partners?		Response To Cytokine Cellular Response To Cytokine Stimulus Nucleocytoplasmic Transport Nuclear Transport Cytokine-mediated Signaling Pathway Mitotic Nuclear Envelope Disassembly Cytoplasmic Transport Nuclear Envelope Disassembly Viral Process Nucleobase-containing Compound Metabolic Process Nucleus Organization RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nuclear Envelope Organization Mitotic Cell Cycle Process Intracellular Transport Cellular Nitrogen Compound Metabolic Process Glucose Transport Regulation Of Cell Death Hexose Transport Regulation Of Cellular Protein Metabolic Process Macromolecule Biosynthetic Process Mitotic Cell Cycle Viral Life Cycle Viral Transcription Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Transport Response To Organic Substance Regulation Of Glucose Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Establishment Of Protein Localization Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance MRNA Transport Regulation Of Proteolysis Carbohydrate Transport RNA Metabolic Process Apoptotic Process Establishment Of Localization In Cell RNA Transport	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Tissue Development Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Developmental Process Gene Expression Regulation Of Binding Regulation Of Gene Expression Anatomical Structure Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Epithelium Development Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Nucleocytoplasmic Transport Embryo Development Ending In Birth Or Egg Hatching Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Biosynthetic Process Regulation Of DNA Methylation Cell Cycle Somatic Stem Cell Maintenance Regulation Of Protein Binding Anatomical Structure Morphogenesis
Tagcloud ?		acids arginine auto best binds cdc34 conjugating karyopherin ligase localization lysine manipulation participates possesses promoted putative rad6 rag1 rearrangement recombinase rich spanning supported ubch2 ubch5a ubiquitin ubiquitylation undergo upstream	arrays attenuated cisplatin cochlea cochlear collectively custom downstream esr1 facilitates immunoblots insights interactomes jak1 machinery mediating modulating modulation nitration otoprotective ototoxicity partners pivotal player relaying stat stat3 trolox wistar
Tagcloud (Difference) ?		acids arginine auto best binds cdc34 conjugating karyopherin ligase localization lysine manipulation participates possesses promoted putative rad6 rag1 rearrangement recombinase rich spanning supported ubch2 ubch5a ubiquitin ubiquitylation undergo upstream	arrays attenuated cisplatin cochlea cochlear collectively custom downstream esr1 facilitates immunoblots insights interactomes jak1 machinery mediating modulating modulation nitration otoprotective ototoxicity partners pivotal player relaying stat stat3 trolox wistar
Tagcloud (Intersection) ?