KPNA1 and SLC25A21-AS1

Number of citations of the paper that reports this interaction (PubMedID 36717926)
49

Data Source:
BioGRID (unspecified method)

		KPNA1	SLC25A21-AS1
Description		karyopherin subunit alpha 1	SLC25A21 antisense RNA 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite NLS-dependent Protein Nuclear Import Complex Glutamatergic Synapse
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Regulation Of DNA Recombination Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein Transport Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Canonical Wnt Signaling Pathway Postsynapse To Nucleus Signaling Pathway
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Inhibition of nitric oxide production
Drugs
Diseases
GWAS		Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		49 interacting genes: ANP32A ANP32B ARNT ATM BCAR3 CDKN1B CENPF CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GNL3L GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP54 NUP62 OGT ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RIPK4 RUNX1T1 SENP2 SF1 SKP2 SLC25A21-AS1 SRP19 STAT1 STAT3 TAF9 UBR5	20 interacting genes: APEX1 ARFGAP1 ARIH1 BROX DAP3 DYNC1LI1 FAM50A GRSF1 GRWD1 KHSRP KPNA1 L2HGDH PAFAH1B1 PPME1 PPP2R1A PSMD6 PTBP3 SLC1A5 TBL2 TXLNA
Entrez ID		3836	100129794
HPRD ID		02819
Ensembl ID		ENSG00000114030	ENSG00000258708
Uniprot IDs		P52294
PDB IDs		2JDQ 3TJ3 4B18 6WX9
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Protein Localization To Nucleus Regulation Of Gene Expression Import Into Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Nuclear Pore Intracellular Protein Localization Positive Regulation Of Gene Expression Regulation Of Developmental Process Hsp90 Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Oxidative Stress Establishment Of Protein Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Transcription Corepressor Binding Regulation Of Erythrocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Glycolytic Process V(D)J Recombination	RNA Binding
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