KPNA1 and TAF9

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		KPNA1	TAF9
Gene Name		karyopherin alpha 1 (importin alpha 5)	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Dendrite	PCAF Complex Nucleoplasm Transcription Factor TFIID Complex STAGA Complex Transcription Factor TFTC Complex Pre-snoRNP Complex MLL1 Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity	P53 Binding DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Activating Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity C2H2 Zinc Finger Domain Binding
	Biological Process	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Intracellular Transport Of Virus	Chromatin Organization Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Gene Expression Viral Process Positive Regulation Of Cell Growth Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Histone H3 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Positive Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism HIV Infection Host Interactions of HIV factors Interferon Signaling Apoptotic execution phase Integration of provirus Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Early Phase of HIV Life Cycle Influenza Life Cycle HIV Life Cycle Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death	RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Chromatin organization HIV Infection HATs acetylate histones RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation Chromatin modifying enzymes RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs
Diseases
GWAS		Calcium levels ( 20705733)
Protein-Protein Interactions		32 interactors: ANP32A ANP32B BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 FOSL1 GOPC HDAC6 HIST2H2BE HIST3H3 IL1RAP KPNB1 LEF1 LMO4 NOSIP NUP50 NUP54 NUP62 ORC4 PAX5 RAG1 RANBP2 RUNX1T1 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5	53 interactors: AHR ALL1 ANK2 APP CEBPB CIITA COIL DRAP1 EEF1A1 ELF3 FBL FBLN1 FEZ1 GALNT6 GTF2B HCFC1 HIST3H3 HNF4A HSF1 KLF6 KMT2A KPNA1 KPNA6 LAMTOR5 MYC NCOA2 NCOR1 NDRG1 NFATC2 NR1D2 NUFIP1 RBM48 RELA RNF138 RPS14 RPS24 RUVBL1 RUVBL2 SF3B3 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF6L TAF7 TAF8 TBCA TP53 UBA1
Entrez ID		3836	6880
HPRD ID		02819	15983
Ensembl ID		ENSG00000114030	ENSG00000085231
Uniprot IDs		B3KXZ2 P52294	Q16594
PDB IDs		2JDQ 3TJ3 4B18
Enriched GO Terms of Interacting Partners?		Response To Cytokine Cellular Response To Cytokine Stimulus Nucleocytoplasmic Transport Nuclear Transport Cytokine-mediated Signaling Pathway Mitotic Nuclear Envelope Disassembly Cytoplasmic Transport Nuclear Envelope Disassembly Viral Process Nucleobase-containing Compound Metabolic Process Nucleus Organization RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nuclear Envelope Organization Mitotic Cell Cycle Process Intracellular Transport Cellular Nitrogen Compound Metabolic Process Glucose Transport Regulation Of Cell Death Hexose Transport Regulation Of Cellular Protein Metabolic Process Macromolecule Biosynthetic Process Mitotic Cell Cycle Viral Life Cycle Viral Transcription Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Transport Response To Organic Substance Regulation Of Glucose Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Establishment Of Protein Localization Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance MRNA Transport Regulation Of Proteolysis Carbohydrate Transport RNA Metabolic Process Apoptotic Process Establishment Of Localization In Cell RNA Transport	RNA Metabolic Process RNA Biosynthetic Process Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Histone Acetylation Biosynthetic Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Cellular Metabolic Process Peptidyl-lysine Modification Chromatin Organization Chromatin Modification Histone Modification Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process
Tagcloud ?		acids arginine auto best binds cdc34 conjugating karyopherin ligase localization lysine manipulation participates possesses promoted putative rad6 rag1 rearrangement recombinase rich spanning supported ubch2 ubch5a ubiquitin ubiquitylation undergo upstream	acetyltransferase associates box coactivators contacted crosslinking dimerization gcn5 hat hence homology interacting m2 m3 macromolecular max mbi moderately motifs myc partner spt3 staga sub substitutions tad tert transactivation trrap
Tagcloud (Difference) ?		acids arginine auto best binds cdc34 conjugating karyopherin ligase localization lysine manipulation participates possesses promoted putative rad6 rag1 rearrangement recombinase rich spanning supported ubch2 ubch5a ubiquitin ubiquitylation undergo upstream	acetyltransferase associates box coactivators contacted crosslinking dimerization gcn5 hat hence homology interacting m2 m3 macromolecular max mbi moderately motifs myc partner spt3 staga sub substitutions tad tert transactivation trrap
Tagcloud (Intersection) ?