KPNA1 and MACROD1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		KPNA1	MACROD1
Name		karyopherin subunit alpha 1	mono-ADP ribosylhydrolase 1
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite NLS-dependent Protein Nuclear Import Complex Glutamatergic Synapse	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Deacetylase Activity O-acetyl-ADP-ribose Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity
	Biological Process	Regulation Of DNA Recombination Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein Transport Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Canonical Wnt Signaling Pathway Postsynapse To Nucleus Signaling Pathway	DNA Damage Response Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Inhibition of nitric oxide production	None
GWAS		Calcium levels ( 20705733 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 28334899 ) Mean corpuscular hemoglobin ( 32888494 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 )	A body shape index ( 34021172 ) Bipolar disorder ( 31043756 ) Body mass index ( 25673413 ) Body mass index and HDL-C (pairwise) ( 33619380 ) Body mass index and triglycerides (pairwise) ( 33619380 ) Fasting insulin ( 34059833 ) Fruit consumption ( 32066663 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 33339817 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Hip index ( 34021172 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Serum uric acid levels ( 32514006 ) Triacylglycerol 56:6 levels ( 31560688 ) Triglyceride levels ( 33339817 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Urate levels ( 31578528 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 )
Interacting Genes		49 interacting genes: ANP32A ANP32B ARNT ATM BCAR3 CDKN1B CENPF CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GNL3L GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP54 NUP62 OGT ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RIPK4 RUNX1T1 SENP2 SF1 SKP2 SLC25A21-AS1 SRP19 STAT1 STAT3 TAF9 UBR5	4 interacting genes: EPB41 IKBKG KPNA1 UXT
Entrez ID		3836	28992
HPRD ID		02819	17448
Ensembl ID		ENSG00000114030	ENSG00000133315
Uniprot IDs		P52294	A0A6Q8PH91 Q9BQ69
PDB IDs		2JDQ 3TJ3 4B18 6WX9	2X47 6LH4
GO Terms Enriched among Interactors		Nucleoplasm Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Protein Localization To Nucleus Regulation Of Gene Expression Import Into Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Nuclear Pore Intracellular Protein Localization Positive Regulation Of Gene Expression Regulation Of Developmental Process Hsp90 Protein Binding Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Oxidative Stress Establishment Of Protein Localization DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Transcription Corepressor Binding Regulation Of Erythrocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Glycolytic Process V(D)J Recombination	Mitotic Spindle Protein-containing Complex Satellite Cell Activation Involved In Skeletal Muscle Regeneration Spindle Pole Linear Polyubiquitin Binding Positive Regulation Of Protein Localization To Cell Cortex Postsynapse To Nucleus Signaling Pathway Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Satellite Cell Activation Establishment Of Organelle Localization Regulation Of Protein Localization To Cell Cortex Spectrin-associated Cytoskeleton Skeletal Muscle Cell Proliferation Establishment Of Localization In Cell NLS-dependent Protein Nuclear Import Complex RPAP3/R2TP/prefoldin-like Complex Transferrin Receptor Binding Anoikis IkappaB Kinase Complex Regulation Of Intestinal Absorption 1-phosphatidylinositol Binding