KPNA1 and SRP19

Number of citations of the paper that reports this interaction (PMID 11682607)
14

Data Source:
HPRD (in vitro)

		KPNA1	SRP19
Gene Name		karyopherin alpha 1 (importin alpha 5)	signal recognition particle 19kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Dendrite	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity	7S RNA Binding Poly(A) RNA Binding
	Biological Process	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Intracellular Transport Of Virus	Translation Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Response To Drug Cellular Protein Metabolic Process
Pathways		Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism HIV Infection Host Interactions of HIV factors Interferon Signaling Apoptotic execution phase Integration of provirus Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Early Phase of HIV Life Cycle Influenza Life Cycle HIV Life Cycle Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death	Translation SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Calcium levels ( 20705733)
Protein-Protein Interactions		32 interactors: ANP32A ANP32B BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 FOSL1 GOPC HDAC6 HIST2H2BE HIST3H3 IL1RAP KPNB1 LEF1 LMO4 NOSIP NUP50 NUP54 NUP62 ORC4 PAX5 RAG1 RANBP2 RUNX1T1 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5	6 interactors: IPO5 IPO7 IPO8 KPNA1 SRP54 TNPO1
Entrez ID		3836	6728
HPRD ID		02819	01644
Ensembl ID		ENSG00000114030
Uniprot IDs		B3KXZ2 P52294	P09132
PDB IDs		2JDQ 3TJ3 4B18	1JID 1MFQ 1RY1 2J37 3KTV
Enriched GO Terms of Interacting Partners?		Response To Cytokine Cellular Response To Cytokine Stimulus Nucleocytoplasmic Transport Nuclear Transport Cytokine-mediated Signaling Pathway Mitotic Nuclear Envelope Disassembly Cytoplasmic Transport Nuclear Envelope Disassembly Viral Process Nucleobase-containing Compound Metabolic Process Nucleus Organization RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nuclear Envelope Organization Mitotic Cell Cycle Process Intracellular Transport Cellular Nitrogen Compound Metabolic Process Glucose Transport Regulation Of Cell Death Hexose Transport Regulation Of Cellular Protein Metabolic Process Macromolecule Biosynthetic Process Mitotic Cell Cycle Viral Life Cycle Viral Transcription Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Transport Response To Organic Substance Regulation Of Glucose Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Establishment Of Protein Localization Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance MRNA Transport Regulation Of Proteolysis Carbohydrate Transport RNA Metabolic Process Apoptotic Process Establishment Of Localization In Cell RNA Transport	Intracellular Protein Transport Establishment Of Protein Localization To Organelle Protein Import Into Nucleus Nuclear Import Protein Targeting Protein Import Protein Localization To Organelle Protein Localization To Nucleus Cellular Protein Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Cytoplasmic Transport Nucleocytoplasmic Transport Nuclear Transport Protein Localization Establishment Of Localization In Cell Cellular Localization NLS-bearing Protein Import Into Nucleus Viral Process Transport Positive Regulation Of Protein Import Into Nucleus SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Ribosomal Protein Import Into Nucleus Positive Regulation Of Protein Transport Regulation Of Intracellular Transport Apoptotic DNA Fragmentation Intracellular Transport Of Virus Protein Import Into Nucleus, Translocation Apoptotic Nuclear Changes Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Intracellular Protein Transmembrane Transport Cellular Response To Amino Acid Stimulus Regulation Of Protein Localization Protein Transmembrane Transport Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of DNA Recombination Execution Phase Of Apoptosis Response To Stimulus
Tagcloud ?		acids arginine auto best binds cdc34 conjugating karyopherin ligase localization lysine manipulation participates possesses promoted putative rad6 rag1 rearrangement recombinase rich spanning supported ubch2 ubch5a ubiquitin ubiquitylation undergo upstream	5q22 adjusted apc caner chose cnv copy discovering exon9 fluorophores gastric integer interrogate intron8 losses obtain original platform probe probes reep5 searched sought surrounding taqman transformed variation volunteers yielded
Tagcloud (Difference) ?		acids arginine auto best binds cdc34 conjugating karyopherin ligase localization lysine manipulation participates possesses promoted putative rad6 rag1 rearrangement recombinase rich spanning supported ubch2 ubch5a ubiquitin ubiquitylation undergo upstream	5q22 adjusted apc caner chose cnv copy discovering exon9 fluorophores gastric integer interrogate intron8 losses obtain original platform probe probes reep5 searched sought surrounding taqman transformed variation volunteers yielded
Tagcloud (Intersection) ?