RAB11FIP3 and ARF4

Number of citations: 0 (PubMedID 11481332)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		RAB11FIP3	ARF4
Name		RAB11 family interacting protein 3	ARF GTPase 4
Structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Mitochondrion Endosome Golgi Apparatus Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Endosome Membrane Membrane Endocytic Vesicle Midbody Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Cleavage Furrow Trans-Golgi Network Membrane Centriolar Satellite Ciliary Basal Body Intercellular Bridge Recycling Endosome Recycling Endosome Membrane Bounding Membrane Of Organelle Postsynaptic Recycling Endosome Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Dendritic Spine Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding GTPase Binding Dynein Light Intermediate Chain Binding Molecular Adaptor Activity	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding GTP Binding NAD+-protein-arginine ADP-ribosyltransferase Activity Phospholipase D Activator Activity
	Biological Process	Mitotic Cytokinesis Vesicle Docking Involved In Exocytosis Microtubule-based Movement Vesicle-mediated Transport Endocytic Recycling Regulation Of Cytokinesis Golgi To Plasma Membrane Protein Transport Positive Regulation Of Cilium Assembly Cell Division Regulation Of Vesicle-mediated Transport Early Endosome To Recycling Endosome Transport Protein Localization To Cilium Negative Regulation Of Adiponectin Secretion Regulation Of Cilium Assembly Regulation Of Early Endosome To Recycling Endosome Transport Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Protein Localization To Centrosome Protein Localization To Cleavage Furrow Regulation Of Endocytic Recycling	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Learning Protein Transport Vesicle-mediated Transport Cell Migration Negative Regulation Of Apoptotic Process Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Transcription By RNA Polymerase II Response To Axon Injury Regulation Of Synapse Organization Cilium Assembly Dendritic Spine Development Protein Localization To Cilium Regulation Of Postsynapse Organization Regulation Of Cilium Assembly Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		VxPx cargo-targeting to cilium	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		None	Guanosine-5'-Diphosphate
GWAS		Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444 ) Heel bone mineral density ( 30598549 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 32888494 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: IFT140	2 novel interactors: ITIH1 RHOA
Interacting Genes		9 interacting genes: ARF4 ARF5 ARF6 ASAP1 RAB11A RAB11B RAB11FIP4 RAB25 TOMM34	16 interacting genes: ADRB2 APBA1 APBA2 APBA3 COPS3 DENND1A DENND1B EGFR HNRNPD IKBKG PTEN RAB11FIP3 RCHY1 SDCBP2 SIRPA SUMO2
Entrez ID		9727	378
HPRD ID		18521	03107
Ensembl ID		ENSG00000090565	ENSG00000168374
Uniprot IDs		O75154	P18085
PDB IDs		2D7C 2HV8 4D0M 4UJ3 4UJ4	1Z6X
GO Terms Enriched among Interactors		GTPase Activity GTP Binding Protein Localization To Cilium Golgi Apparatus G Protein Activity Endocytic Recycling Myosin V Binding Recycling Endosome Membrane Intracellular Protein Localization Vesicle-mediated Transport Intracellular Transport Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Protein Localization To Cleavage Furrow Establishment Of Protein Localization Positive Regulation Of Epithelial Cell Migration Plasma Membrane Bounded Cell Projection Organization Cleavage Furrow Cellular Localization Establishment Of Localization In Cell Regulation Of Cell Projection Assembly Positive Regulation Of Mitotic Cytokinetic Process Amyloid-beta Clearance By Transcytosis Regulation Of Epithelial Cell Migration Protein Transport Endosomal Transport Cell Projection Organization Regulation Of Cytokinesis Protein Localization To Organelle Regulation Of Cilium Assembly Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Transcytosis Regulation Of Endocytic Recycling Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Pigment Granule Localization Amyloid-beta Clearance Regulation Of Cell Division Protein Localization To Cell Surface Nucleotide Binding Localization Within Membrane Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Exocytosis Regulation Of Protein Localization To Cell Surface	Dendritic Spine Amyloid-beta Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Size Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Endocytic Recycling Regulation Of Macromolecule Metabolic Process In Utero Embryonic Development Chordate Embryonic Development Regulation Of Cell Communication Regulation Of Signaling Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Establishment Of Protein Localization Regulation Of Metabolic Process Chemical Synaptic Transmission Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Trans-synaptic Signaling Synaptic Signaling Regulation Of Protein Modification Process Vesicle-mediated Transport To The Plasma Membrane Phosphatidylinositol Phosphate Binding Cerebral Cortex Cell Migration Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Localization Regulation Of Gene Expression Protein Transport Regulation Of Proteolysis Establishment Of Localization In Cell Protein Homodimerization Activity Cellular Response To Estradiol Stimulus Enzyme Binding Regulation Of Macromolecule Biosynthetic Process Response To Electrical Stimulus Positive Regulation Of Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mini Excitatory Postsynaptic Potential Intracellular Transport Presynaptic Modulation Of Chemical Synaptic Transmission Locomotory Behavior