DMD and UTRN

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		DMD	UTRN
Description		dystrophin	utrophin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Surface Actin Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Myofibril Z Disc Cell-substrate Junction Filopodium Filopodium Membrane Protein-containing Complex Sarcolemma Costamere Neuron Projection Terminus Membrane Raft Synapse Postsynaptic Membrane	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Dystrophin-associated Glycoprotein Complex Membrane Filopodium Filopodium Membrane Neuromuscular Junction Protein-containing Complex Ciliary Basal Body Sarcolemma Synapse Postsynaptic Membrane Extracellular Exosome Contractile Ring
	Molecular Function	Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Metal Ion Binding Nitric-oxide Synthase Binding	Actin Binding Integrin Binding Protein Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Regulation Of Heart Rate Muscle Contraction Cytoskeleton Organization Muscle Organ Development Skeletal Muscle Tissue Development Intracellular Protein Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Maintenance Of Blood-brain Barrier Response To Muscle Stretch Peptide Biosynthetic Process Regulation Of System Process Motile Cilium Assembly Positive Regulation Of Neuron Differentiation Muscle Cell Cellular Homeostasis Neuron Development Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly Cardiac Muscle Cell Action Potential Regulation Of Muscle System Process Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport	Positive Regulation Of Cell-matrix Adhesion Muscle Contraction Muscle Organ Development Synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport
Pathways		Non-integrin membrane-ECM interactions Striated Muscle Contraction Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Golodirsen	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Dilated cardiomyopathy (DCM) Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)
GWAS		Ankle-brachial index ( 31388106) Anxiety in major depressive disorder ( 24047446) Body mass index ( 28892062) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Major depressive disorder ( 34099189) Mild influenza (H1N1) infection ( 26379185) Response to anti-depressant treatment in major depressive disorder ( 22041458) Temporomandibular joint disorder ( 28081371) Waist circumference ( 28552196)	Age at first sexual intercourse ( 34211149) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density x serum urate levels interaction ( 34046847) Loneliness (multivariate analysis) ( 27629369) Multisite chronic pain ( 31194737 33830993) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Refractive error ( 32231278) Remission after SSRI treatment in MDD or openness ( 29559929) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mepolizumab in severe asthma ( 29229094) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome in migraine without aura ( 32918390)
Interacting Genes		32 interacting genes: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG FOXP1 HAUS1 HNF4A KCNJ12 KRT19 KRT8 MAP3K5 PGM5 PICK1 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 TRIM63 USP7 UTRN	20 interacting genes: ACTA1 ACTN2 C1QTNF9 CALM1 DAG1 DISC1 DMD DRP2 DTNA DTNB ITGB1BP1 MARCHF5 PCNT PGM5 PTEN PTPN12 SASH1 SNTA1 SNTB1 SNTB2
Entrez ID		1756	7402
HPRD ID		02303	00547
Ensembl ID		ENSG00000198947	ENSG00000152818
Uniprot IDs		A0A087WV90 A0A0S2Z3B5 A0A0S2Z3J7 A0A5H1ZRP9 A0A5H1ZRQ1 A0A5H1ZRQ8 A0A5H1ZRR9 A0A804HKY9 A7E212 P11532 Q16484 Q4G0X0	P46939 Q5T097 Q6LBS5
PDB IDs		1DXX 1EG3 1EG4 3UUN 9D58	1BHD 1QAG 6M5G
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Sarcolemma Cytoskeleton Muscle Contraction Muscle System Process Syntrophin Complex Structural Molecule Activity Synapse Cytoplasm Actin Binding Costamere Filopodium Cell Body PDZ Domain Binding Mesenchyme Migration Skeletal Muscle Thin Filament Assembly Protein-containing Complex Contractile Ring Dense Core Granule Exocytosis Intermediate Filament Cytoskeleton Z Disc Cell Communication Positive Regulation Of Cell-matrix Adhesion System Process Glial Cell Development Vinculin Binding Ciliary Basal Body Lamellipodium Synaptic Signaling Regulation Of Transport Regulation Of System Process Glutamatergic Synapse Secretory Granule Localization Programmed Necrotic Cell Death Heart Contraction Cell-cell Signaling Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development Presynapse Myosin Binding Signaling Focal Adhesion Plasma Membrane Actomyosin Structure Organization Positive Regulation Of Receptor Internalization Cellular Response To Nutrient Levels Myofibril Assembly Heart Process Organelle Assembly Amyloid-beta Complex	Dystrophin-associated Glycoprotein Complex Sarcolemma Cytoskeleton Synapse Focal Adhesion Costamere Filopodium Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Synaptic Signaling PDZ Domain Binding Muscle Contraction Actin Binding Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Syntrophin Complex Cell Projection Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Communication Muscle System Process Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell-matrix Adhesion Structural Constituent Of Muscle Regulation Of Monoatomic Ion Transmembrane Transport Channel Activator Activity Protein-containing Complex Cell-substrate Junction Sarcomere Regulation Of System Process Regulation Of Metal Ion Transport Positive Regulation Of Cell-matrix Adhesion Dystroglycan Binding Structural Molecule Activity Cell-cell Signaling Cytoplasm Vinculin Binding Nitric-oxide Synthase Binding Calmodulin Binding Signaling Regulation Of Heart Contraction Titin Binding Anchoring Junction Regulation Of Monoatomic Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Cell-substrate Adhesion Cytoskeleton Organization Regulation Of Membrane Potential Nuclear Periphery Muscle Cell Development Plasma Membrane
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