DMD and SNTG2

Number of citations of the paper that reports this interaction (PubMedID 10747910)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		DMD	SNTG2
Description		dystrophin	syntrophin gamma 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Surface Actin Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Myofibril Z Disc Cell-substrate Junction Filopodium Filopodium Membrane Protein-containing Complex Sarcolemma Costamere Neuron Projection Terminus Membrane Raft Synapse Postsynaptic Membrane	Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Sarcolemma
	Molecular Function	Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Metal Ion Binding Nitric-oxide Synthase Binding	Actin Binding Structural Molecule Activity Protein Binding PDZ Domain Binding Neuroligin Family Protein Binding
	Biological Process	Regulation Of Heart Rate Muscle Contraction Cytoskeleton Organization Muscle Organ Development Skeletal Muscle Tissue Development Intracellular Protein Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Maintenance Of Blood-brain Barrier Response To Muscle Stretch Peptide Biosynthetic Process Regulation Of System Process Motile Cilium Assembly Positive Regulation Of Neuron Differentiation Muscle Cell Cellular Homeostasis Neuron Development Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly Cardiac Muscle Cell Action Potential Regulation Of Muscle System Process Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport	Central Nervous System Development
Pathways		Non-integrin membrane-ECM interactions Striated Muscle Contraction Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Golodirsen
Diseases		Dilated cardiomyopathy (DCM) Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)
GWAS		Ankle-brachial index ( 31388106) Anxiety in major depressive disorder ( 24047446) Body mass index ( 28892062) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Major depressive disorder ( 34099189) Mild influenza (H1N1) infection ( 26379185) Response to anti-depressant treatment in major depressive disorder ( 22041458) Temporomandibular joint disorder ( 28081371) Waist circumference ( 28552196)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Calcific aortic valve stenosis ( 32141789) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hypothyroidism ( 27182965) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)
Interacting Genes		32 interacting genes: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG FOXP1 HAUS1 HNF4A KCNJ12 KRT19 KRT8 MAP3K5 PGM5 PICK1 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 TRIM63 USP7 UTRN	13 interacting genes: ADGRB1 BET1 DMD DTNA DTNB HACE1 MIPOL1 MPP3 PALS1 RPS6KA1 SCN5A VANGL2 VCPIP1
Entrez ID		1756	54221
HPRD ID		02303	16374
Ensembl ID		ENSG00000198947	ENSG00000172554
Uniprot IDs		A0A087WV90 A0A0S2Z3B5 A0A0S2Z3J7 A0A5H1ZRP9 A0A5H1ZRQ1 A0A5H1ZRQ8 A0A5H1ZRR9 A0A804HKY9 A7E212 P11532 Q16484 Q4G0X0	Q9NY99
PDB IDs		1DXX 1EG3 1EG4 3UUN 9D58	7QQL
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Sarcolemma Cytoskeleton Muscle Contraction Muscle System Process Syntrophin Complex Structural Molecule Activity Synapse Cytoplasm Actin Binding Costamere Filopodium Cell Body PDZ Domain Binding Mesenchyme Migration Skeletal Muscle Thin Filament Assembly Protein-containing Complex Contractile Ring Dense Core Granule Exocytosis Intermediate Filament Cytoskeleton Z Disc Cell Communication Positive Regulation Of Cell-matrix Adhesion System Process Glial Cell Development Vinculin Binding Ciliary Basal Body Lamellipodium Synaptic Signaling Regulation Of Transport Regulation Of System Process Glutamatergic Synapse Secretory Granule Localization Programmed Necrotic Cell Death Heart Contraction Cell-cell Signaling Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development Presynapse Myosin Binding Signaling Focal Adhesion Plasma Membrane Actomyosin Structure Organization Positive Regulation Of Receptor Internalization Cellular Response To Nutrient Levels Myofibril Assembly Heart Process Organelle Assembly Amyloid-beta Complex	PDZ Domain Binding Striated Muscle Contraction Nitric-oxide Synthase Binding Lateral Plasma Membrane Membrane Organization Sarcolemma Cell Communication Golgi Organization Synaptic Signaling Anchoring Junction Membrane Fusion Neuron Development Cell-cell Junction Synapse Regulation Of Sodium Ion Transmembrane Transport Muscle Contraction Cardiac Muscle Cell Action Potential Cardiac Muscle Contraction Voltage-gated Sodium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential Voltage-gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential Voltage-gated Sodium Channel Activity Involved In SA Node Cell Action Potential Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Myelin Sheath Abaxonal Region Muscle System Process Cell-cell Signaling Signaling Regulation Of Sodium Ion Transport Bundle Of His Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Regulation Of Cardiac Muscle Contraction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Serotonergic Neuron Axon Guidance Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Apical Plasma Membrane Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Syntrophin Complex
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