DMD and CDC25A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DMD	CDC25A
Description		dystrophin	cell division cycle 25A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Surface Actin Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Myofibril Z Disc Cell-substrate Junction Filopodium Filopodium Membrane Protein-containing Complex Sarcolemma Costamere Neuron Projection Terminus Membrane Raft Synapse Postsynaptic Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Metal Ion Binding Nitric-oxide Synthase Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding Protein-folding Chaperone Binding
	Biological Process	Regulation Of Heart Rate Muscle Contraction Cytoskeleton Organization Muscle Organ Development Skeletal Muscle Tissue Development Intracellular Protein Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Maintenance Of Blood-brain Barrier Response To Muscle Stretch Peptide Biosynthetic Process Regulation Of System Process Motile Cilium Assembly Positive Regulation Of Neuron Differentiation Muscle Cell Cellular Homeostasis Neuron Development Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly Cardiac Muscle Cell Action Potential Regulation Of Muscle System Process Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Cell Population Proliferation Response To Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Replication Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Non-integrin membrane-ECM interactions Striated Muscle Contraction Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Transcription of E2F targets under negative control by DREAM complex Polo-like kinase mediated events Activation of ATR in response to replication stress Ub-specific processing proteases Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Golodirsen
Diseases		Dilated cardiomyopathy (DCM) Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)
GWAS		Ankle-brachial index ( 31388106) Anxiety in major depressive disorder ( 24047446) Body mass index ( 28892062) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Major depressive disorder ( 34099189) Mild influenza (H1N1) infection ( 26379185) Response to anti-depressant treatment in major depressive disorder ( 22041458) Temporomandibular joint disorder ( 28081371) Waist circumference ( 28552196)	A body shape index ( 34021172) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Loneliness (multivariate analysis) ( 27629369) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 27618447) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		32 interacting genes: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG FOXP1 HAUS1 HNF4A KCNJ12 KRT19 KRT8 MAP3K5 PGM5 PICK1 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 TRIM63 USP7 UTRN	57 interacting genes: APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDK5 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR EP300 FAM193B FBXW11 FGF21 FTH1 HDAC11 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NAA11 NFKBIB NFYA PEX19 PIM1 PIN1 PKM POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 SRC UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		1756	993
HPRD ID		02303	00305
Ensembl ID		ENSG00000198947	ENSG00000164045
Uniprot IDs		A0A087WV90 A0A0S2Z3B5 A0A0S2Z3J7 A0A5H1ZRP9 A0A5H1ZRQ1 A0A5H1ZRQ8 A0A5H1ZRR9 A0A804HKY9 A7E212 P11532 Q16484 Q4G0X0	D8KXX0 K7N7S0 P30304
PDB IDs		1DXX 1EG3 1EG4 3UUN 9D58	1C25 8ROZ
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Sarcolemma Cytoskeleton Muscle Contraction Muscle System Process Syntrophin Complex Structural Molecule Activity Synapse Cytoplasm Actin Binding Costamere Filopodium Cell Body PDZ Domain Binding Mesenchyme Migration Skeletal Muscle Thin Filament Assembly Protein-containing Complex Contractile Ring Dense Core Granule Exocytosis Intermediate Filament Cytoskeleton Z Disc Cell Communication Positive Regulation Of Cell-matrix Adhesion System Process Glial Cell Development Vinculin Binding Ciliary Basal Body Lamellipodium Synaptic Signaling Regulation Of Transport Regulation Of System Process Glutamatergic Synapse Secretory Granule Localization Programmed Necrotic Cell Death Heart Contraction Cell-cell Signaling Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development Presynapse Myosin Binding Signaling Focal Adhesion Plasma Membrane Actomyosin Structure Organization Positive Regulation Of Receptor Internalization Cellular Response To Nutrient Levels Myofibril Assembly Heart Process Organelle Assembly Amyloid-beta Complex	Nucleus Cytosol Cytoplasm Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Protein Kinase Activity Regulation Of Cell Cycle Kinase Activity Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Nucleobase-containing Compound Metabolic Process MAPK Cascade G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Localization Phosphoserine Residue Binding Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine Kinase Activity Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Protein Serine/threonine Kinase Activity Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Signal Transduction Regulation Of Cellular Localization Protein Phosphorylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Regulation Of Intracellular Protein Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Modification Process Regulation Of TORC1 Signaling
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