DMD and PGM5

Number of citations of the paper that reports this interaction (PubMedID 10867799)
0

Data Source:
HPRD (in vitro, in vivo)

		DMD	PGM5
Description		dystrophin	phosphoglucomutase 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Surface Actin Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Myofibril Z Disc Cell-substrate Junction Filopodium Filopodium Membrane Protein-containing Complex Sarcolemma Costamere Neuron Projection Terminus Membrane Raft Synapse Postsynaptic Membrane	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Spot Adherens Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Dystrophin-associated Glycoprotein Complex Membrane Z Disc Cell-substrate Junction Sarcolemma Costamere Anchoring Junction
	Molecular Function	Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Metal Ion Binding Nitric-oxide Synthase Binding	Magnesium Ion Binding Phosphoglucomutase Activity Structural Molecule Activity Intramolecular Phosphotransferase Activity
	Biological Process	Regulation Of Heart Rate Muscle Contraction Cytoskeleton Organization Muscle Organ Development Skeletal Muscle Tissue Development Intracellular Protein Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Maintenance Of Blood-brain Barrier Response To Muscle Stretch Peptide Biosynthetic Process Regulation Of System Process Motile Cilium Assembly Positive Regulation Of Neuron Differentiation Muscle Cell Cellular Homeostasis Neuron Development Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly Cardiac Muscle Cell Action Potential Regulation Of Muscle System Process Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport	Carbohydrate Metabolic Process Cell Adhesion Striated Muscle Tissue Development Myofibril Assembly
Pathways		Non-integrin membrane-ECM interactions Striated Muscle Contraction Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Golodirsen
Diseases		Dilated cardiomyopathy (DCM) Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)
GWAS		Ankle-brachial index ( 31388106) Anxiety in major depressive disorder ( 24047446) Body mass index ( 28892062) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Major depressive disorder ( 34099189) Mild influenza (H1N1) infection ( 26379185) Response to anti-depressant treatment in major depressive disorder ( 22041458) Temporomandibular joint disorder ( 28081371) Waist circumference ( 28552196)	Bipolar disorder ( 22925353) Metabolite levels ( 23823483)
Interacting Genes		32 interacting genes: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG FOXP1 HAUS1 HNF4A KCNJ12 KRT19 KRT8 MAP3K5 PGM5 PICK1 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 TRIM63 USP7 UTRN	2 interacting genes: DMD UTRN
Entrez ID		1756	5239
HPRD ID		02303	02990
Ensembl ID		ENSG00000198947	ENSG00000154330
Uniprot IDs		A0A087WV90 A0A0S2Z3B5 A0A0S2Z3J7 A0A5H1ZRP9 A0A5H1ZRQ1 A0A5H1ZRQ8 A0A5H1ZRR9 A0A804HKY9 A7E212 P11532 Q16484 Q4G0X0	Q15124
PDB IDs		1DXX 1EG3 1EG4 3UUN 9D58	7U21
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Sarcolemma Cytoskeleton Muscle Contraction Muscle System Process Syntrophin Complex Structural Molecule Activity Synapse Cytoplasm Actin Binding Costamere Filopodium Cell Body PDZ Domain Binding Mesenchyme Migration Skeletal Muscle Thin Filament Assembly Protein-containing Complex Contractile Ring Dense Core Granule Exocytosis Intermediate Filament Cytoskeleton Z Disc Cell Communication Positive Regulation Of Cell-matrix Adhesion System Process Glial Cell Development Vinculin Binding Ciliary Basal Body Lamellipodium Synaptic Signaling Regulation Of Transport Regulation Of System Process Glutamatergic Synapse Secretory Granule Localization Programmed Necrotic Cell Death Heart Contraction Cell-cell Signaling Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development Presynapse Myosin Binding Signaling Focal Adhesion Plasma Membrane Actomyosin Structure Organization Positive Regulation Of Receptor Internalization Cellular Response To Nutrient Levels Myofibril Assembly Heart Process Organelle Assembly Amyloid-beta Complex	Vinculin Binding Dystrophin-associated Glycoprotein Complex Filopodium Membrane Regulation Of Sodium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Filopodium Sarcolemma Muscle Organ Development Muscle Structure Development Muscle Contraction Postsynaptic Membrane Muscle System Process Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Metal Ion Transport Synaptic Signaling Actin Binding Syntrophin Complex Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Monoatomic Ion Transport Cell-substrate Junction Contractile Ring Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Dystroglycan Binding Cell-cell Signaling Signaling Nitric-oxide Synthase Binding Cell Communication Costamere Protein-containing Complex Neuron Projection Terminus Regulation Of Skeletal Muscle Contraction Muscle Cell Cellular Homeostasis Peptide Biosynthetic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Synapse Myosin Binding Response To Muscle Stretch Maintenance Of Blood-brain Barrier Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cardiac Muscle Cell Action Potential Structural Constituent Of Muscle Cardiac Muscle Contraction Motile Cilium Assembly Myofibril Peptide Metabolic Process Animal Organ Development Cytoskeleton System Process
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