JAK3 and TIAF1

Number of citations of the paper that reports this interaction (PMID 10733938)
2

Data Source:
HPRD (two hybrid, in vivo)

		JAK3	TIAF1
Gene Name		Janus kinase 3	TGFB1-induced anti-apoptotic factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Endomembrane System Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Nucleus
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Hormone Receptor Binding	Molecular_function
	Biological Process	Negative Regulation Of Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein STAT Protein Import Into Nucleus Cell Migration Peptidyl-tyrosine Phosphorylation B Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-4-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of FasL Biosynthetic Process Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of T Cell Activation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9 Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Apoptotic Process I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Apoptotic Process
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: ALK APOA1 CD247 CD40 CD81 CDK1 CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B TIAF1 UHRF2 VIL1	1 interactors: JAK3
Entrez ID		3718	9220
HPRD ID		02547	10268
Ensembl ID		ENSG00000105639
Uniprot IDs		P52333	O95411
PDB IDs		1YVJ 3LXK 3LXL 3PJC 3ZC6 4HVD 4HVG 4HVH 4HVI
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Signal Transduction Response To Growth Hormone Cytokine-mediated Signaling Pathway Signaling Cell Communication Immune System Process Defense Response Cellular Response To Organic Substance Regulation Of Cell Activation Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Stimulus Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Peptide JAK-STAT Cascade Immune Response Regulation Of Signal Transduction Regulation Of Signaling Response To Organic Substance Response To Cytokine Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Regulation Of Kinase Activity Response To Hormone Regulation Of Phosphorylation Innate Immune Response Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Hormone Stimulus Cell Proliferation Cellular Response To Organonitrogen Compound Regulation Of JAK-STAT Cascade Response To Peptide Regulation Of Cell Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Proliferation	Negative Regulation Of FasL Biosynthetic Process Negative Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of T-helper 1 Cell Differentiation STAT Protein Import Into Nucleus Response To Interleukin-9 Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-15 Negative Regulation Of T-helper 1 Type Immune Response Tyrosine Phosphorylation Of STAT Protein Regulation Of T-helper 1 Cell Differentiation Response To Interleukin-2 Interleukin-4-mediated Signaling Pathway Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Interleukin-10 Production Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Interleukin-12 Production JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of Alpha-beta T Cell Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of T Cell Apoptotic Process Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Leukocyte Apoptotic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of T Cell Differentiation Negative Regulation Of Adaptive Immune Response T Cell Homeostasis Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Peptidyl-tyrosine Autophosphorylation Response To Growth Hormone Cellular Response To Interleukin-4 Regulation Of T Cell Apoptotic Process Negative Regulation Of Lymphocyte Differentiation Response To Interleukin-4 JAK-STAT Cascade Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Lymphocyte Apoptotic Process Regulation Of Interleukin-12 Production Lymphocyte Homeostasis Regulation Of Cytokine Production Involved In Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Proliferation Leukocyte Homeostasis Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction	acted aggregated aggregates aggregating anchorage antiapoptotic capsules causing disappear exhibits intriguingly jnk1 matrices neuroblastoma neurodegeneration nondemented oxidoreductase peritumor smad smad4 spontaneously stroma suppressing suppressors synergistically upregulated wox1 ww wwox
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction	acted aggregated aggregates aggregating anchorage antiapoptotic capsules causing disappear exhibits intriguingly jnk1 matrices neuroblastoma neurodegeneration nondemented oxidoreductase peritumor smad smad4 spontaneously stroma suppressing suppressors synergistically upregulated wox1 ww wwox
Tagcloud (Intersection) ?