PRMT5 and PDGFRA

Number of citations of the paper that reports this interaction (PubMedID 30057274)
0

Data Source:
BioGRID (enzymatic study)

		PRMT5	PDGFRA
Description		protein arginine methyltransferase 5	platelet derived growth factor receptor alpha
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex Methylosome Histone Methyltransferase Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Cilium External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Protein-containing Complex Cell Projection Receptor Complex Platelet-derived Growth Factor Receptor-ligand Complex
	Molecular Function	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone H4R3 Methyltransferase Activity Protein-containing Complex Binding Protein Heterodimerization Activity E-box Binding Histone H3 Methyltransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Protein-containing Complex Binding Platelet-derived Growth Factor Binding Phospholipase C Activator Activity
	Biological Process	Spliceosomal SnRNP Assembly Chromatin Organization Chromatin Remodeling DNA-templated Transcription Termination Regulation Of DNA-templated Transcription Regulation Of Mitotic Nuclear Division Regulation Of Gene Expression Peptidyl-arginine Methylation Methylation Circadian Regulation Of Gene Expression Peptidyl-arginine N-methylation Endothelial Cell Activation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Rhythmic Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Chemotaxis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Estrogen Metabolic Process Positive Regulation Of Cell Population Proliferation Female Gonad Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Platelet Activation Cell Migration Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Regulation Of Actin Cytoskeleton Organization Leydig Cell Differentiation Cellular Response To Reactive Oxygen Species Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Positive Regulation Of Calcium-mediated Signaling White Fat Cell Differentiation Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Myofibril Assembly Roof Of Mouth Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation	PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Imatinib-resistant PDGFR mutants Sunitinib-resistant PDGFR mutants Regorafenib-resistant PDGFR mutants Sorafenib-resistant PDGFR mutants PDGFR mutants bind TKIs
Drugs			Becaplermin Imatinib Sunitinib XL820 Olaratumab Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin keratinocyte (neonatal) Tivozanib Fostamatinib Erdafitinib Amuvatinib Ripretinib
Diseases			Glioma
GWAS		Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)	Adult asthma ( 27611488) Asthma ( 27611488) Blood protein levels ( 30072576) Cadmium levels ( 26025379) Core binding factor acute myeloid leukemia ( 27903959) Corneal astigmatism ( 29422769 22144915) Corneal curvature ( 24963161 23401653 21665993) Height ( 18193045) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lupus nephritis in systemic lupus erythematosus ( 24925725) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular volume ( 29403010 20139978) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30578418) Red blood cell count ( 28453575 29403010 20139978) Serum VEGFR2 concentration ( 25411163) Systolic blood pressure ( 30578418) Uterine fibroids ( 30194396 31649266) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		93 interacting genes: ACE2 AIRIM ARGLU1 CACNB2 CALU CAPN1 CDC37 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A DRC4 DUSP14 EIF4A1 EIF4A3 ELOA EPHB6 EZH2 FAM47E FAM76B G3BP2 GLI1 GRHL3 GTPBP2 H2AC20 H2AC4 H3-4 H3-5 H4C1 H4C16 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 KANK2 LDHAL6B LENG8 LNX1 LUC7L MAGEB2 MBP MCRS1 MEF2D MXI1 MYOD1 MYOG NCL NELFCD NTAQ1 OLA1 PDCD4 PDGFRA PHYHIP POLR2A PRPF38A RBFOX2 RBM23 RNF4 RSRP1 SIN3A SLU7 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 SUPT5H TRIB3 TRIM54 TYK2 UBC UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZMYND19 ZNF2 ZNF224 ZNF436 ZUP1	62 interacting genes: AKT1 ARNT AURKA BECN1 CAV1 CAV3 CBL CCND2 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CRK CRKL EGFR ERBB2 ERBB3 FBXO25 FZR1 GRB14 GRM1 HGF ITGAV ITGB3 JAK1 KASH5 KDELR2 LATS2 MAP2K5 MYC NF2 NHERF1 PDGFA PDGFB PDGFC PDGFRB PIK3CA PIK3R1 PLCG1 PLPP6 PRMT5 PTPN11 RAF1 SHB SHF SMURF1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B STK11 TERT TGFBR2 TP53 TTYH2 ULBP2
Entrez ID		10419	5156
HPRD ID		04955	01429
Ensembl ID		ENSG00000100462	ENSG00000134853
Uniprot IDs		B4DV00 O14744	P16234
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7BOC 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9E3C 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R	1GQ5 5GRN 5K5X 6A32 6JOI 6JOJ 6JOK 6JOL 7LBF 7RAM 8PQH 8PQI 8PQJ 8PQK 9GZH
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Methylosome RNA Binding Regulation Of RNA Splicing Regulation Of Metabolic Process U1 SnRNP Binding U1 SnRNP Regulation Of MRNA Splicing, Via Spliceosome Growth Hormone Receptor Binding Regulation Of Transcription By RNA Polymerase II Protein Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane RNA Splicing Spliceosomal Complex Regulation Of MRNA Processing MRNA Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT MRNA Splicing, Via Spliceosome Small Nuclear Ribonucleoprotein Complex Regulation Of MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions PICln-Sm Protein Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Chromosome MRNA Processing Protein Tyrosine Kinase Activity Structural Constituent Of Chromatin Growth Hormone Receptor Signaling Pathway 7-methylguanosine Cap Hypermethylation Protein Localization To Chromatin Protein-RNA Complex Assembly Extrinsic Component Of Plasma Membrane Protein Modification Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process U4 SnRNP Negative Regulation Of Macromolecule Biosynthetic Process	Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Epithelial Cell Proliferation Developmental Process Cellular Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Cycle Regulation Of Apoptotic Process Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Cell Differentiation Animal Organ Development Negative Regulation Of Cell Differentiation Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Migration Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Motility Regulation Of Cell Development Response To Epidermal Growth Factor Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process
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