PRMT5 and GTPBP2

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PRMT5	GTPBP2
Gene Name		protein arginine methyltransferase 5	GTP binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome	Intracellular Membrane-bounded Organelle
	Molecular Function	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Ribonucleoprotein Complex Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Cell Proliferation Gene Expression Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression NcRNA Metabolic Process Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation	Biological_process Metabolic Process
Pathways		Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		67 interactors: ARGLU1 CALU CAPN1 CCAR2 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A EZH2 FAM76B GRHL3 GTPBP2 H3F3C HIST1H3A HIST1H4A HIST2H2AC HOXC4 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NELFCD NUDCD2 OLA1 PHYHIP PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SSTR1 SUPT5H TRIB3 TYK2 WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUFSP	4 interactors: KDM1A PRMT5 PRMT6 SUV39H1
Entrez ID		10419	54676
HPRD ID		04955	08465
Ensembl ID		ENSG00000100462	ENSG00000172432
Uniprot IDs		O14744	Q9BX10
PDB IDs		4GQB
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Chromatin Modification Regulation Of RNA Metabolic Process MRNA Processing Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated MRNA Metabolic Process RNA Splicing RNA Biosynthetic Process RNA Processing Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Transcription, DNA-templated MRNA Splicing, Via Spliceosome Regulation Of Nucleic Acid-templated Transcription RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Biogenesis Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Peptidyl-amino Acid Modification Positive Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Chromatin Remodeling Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process	Histone Modification Chromatin Modification Histone Methylation Chromatin Organization Histone H4-R3 Methylation Protein Methylation Peptidyl-arginine N-methylation Chromosome Organization Histone Arginine Methylation Peptidyl-arginine Methylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Methylation Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Primitive Erythrocyte Differentiation Peptidyl-amino Acid Modification Histone H3-R2 Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Organelle Organization RNA Metabolic Process Cellular Protein Modification Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Rhythmic Process Histone H3-K9 Dimethylation Ribonucleoprotein Complex Biogenesis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Megakaryocyte Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Histone H3-K9 Trimethylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Gene Expression
Tagcloud ?		acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase	anticodon causes clear defects define discover encoded eukaryotes homeostasis little nervous neurodegeneration partner pelota recycling rescue respond ribosome rnas similarly specifically stalling surveillance transfer translation trna trnas unmask widespread
Tagcloud (Difference) ?		acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase	anticodon causes clear defects define discover encoded eukaryotes homeostasis little nervous neurodegeneration partner pelota recycling rescue respond ribosome rnas similarly specifically stalling surveillance transfer translation trna trnas unmask widespread
Tagcloud (Intersection) ?