PRMT5 and MYOG

Number of citations of the paper that reports this interaction (PMID 19188441)
24

Data Source:
BioGRID (pull down)

		PRMT5	MYOG
Gene Name		protein arginine methyltransferase 5	myogenin (myogenic factor 4)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome	Nucleus Nucleoplasm Transcription Factor Complex Protein-DNA Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Ribonucleoprotein Complex Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Chromatin DNA Binding Sequence-specific DNA Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Cell Proliferation Gene Expression Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression NcRNA Metabolic Process Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation	Ossification Cell Cycle Skeletal Muscle Tissue Development Negative Regulation Of Cell Proliferation Positive Regulation Of Myotube Differentiation Positive Regulation Of Muscle Atrophy Regulation Of Satellite Cell Proliferation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Response To Denervation Involved In Regulation Of Muscle Adaptation Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Regulation Of Myoblast Fusion Positive Regulation Of Myoblast Fusion
Pathways		Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		67 interactors: ARGLU1 CALU CAPN1 CCAR2 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A EZH2 FAM76B GRHL3 GTPBP2 H3F3C HIST1H3A HIST1H4A HIST2H2AC HOXC4 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NELFCD NUDCD2 OLA1 PHYHIP PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SSTR1 SUPT5H TRIB3 TYK2 WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUFSP	35 interactors: BBS4 CALM1 CALM2 CALM3 CARM1 CCDC28A CDH18 CLUAP1 CSRP3 EIF4E2 ELSPBP1 FTL HYPM ID1 ID2 ID3 IKBIP MAPK3 MDFI MEF2A MEF2C MLH1 NF1 PACRGL POLR2C PRMT5 SEPT5 SP1 SRF TAF6L TCF3 TRIM43 TTC25 TXNDC9 YME1L1
Entrez ID		10419	4656
HPRD ID		04955	01167
Ensembl ID		ENSG00000100462	ENSG00000122180
Uniprot IDs		O14744	P15173
PDB IDs		4GQB
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Chromatin Modification Regulation Of RNA Metabolic Process MRNA Processing Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated MRNA Metabolic Process RNA Splicing RNA Biosynthetic Process RNA Processing Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Transcription, DNA-templated MRNA Splicing, Via Spliceosome Regulation Of Nucleic Acid-templated Transcription RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Biogenesis Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Peptidyl-amino Acid Modification Positive Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Chromatin Remodeling Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process	Cell Activation Positive Regulation Of Phosphatase Activity Heart Development Organ Morphogenesis Positive Regulation Of Dephosphorylation Anatomical Structure Development Organ Development Cardiac Myofibril Assembly Determination Of Heart Left/right Asymmetry Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Anatomical Structure Morphogenesis Regulation Of Heart Contraction Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Cellular Metabolic Process Developmental Process Cardiovascular System Development Embryo Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Development Embryonic Organ Morphogenesis Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Binding Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Phosphatase Activity Organelle Organization System Development Determination Of Left/right Symmetry Multicellular Organismal Development Neurotrophin TRK Receptor Signaling Pathway Determination Of Bilateral Symmetry Neurotrophin Signaling Pathway Response To Calcium Ion Positive Regulation Of Lyase Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Tissue Development Regulation Of Osteoblast Differentiation Response To Growth Factor Regulation Of Dephosphorylation Detection Of Calcium Ion Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Communication By Electrical Coupling Regulation Of Adenylate Cyclase Activity Muscle System Process Cell Development
Tagcloud ?		acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase	boxes c2c12 c3h10t1 cardiotoxin colocalized dux4 duxbl dystrophy elongated embryogenesis facioscapulohumeral fshd homeobox homeodomain hyper multipotent muscles myoblast myocytes myod myogenesis myogenic myotubes organogenesis overexpressions quiescent regenerated satellite trunk
Tagcloud (Difference) ?		acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase	boxes c2c12 c3h10t1 cardiotoxin colocalized dux4 duxbl dystrophy elongated embryogenesis facioscapulohumeral fshd homeobox homeodomain hyper multipotent muscles myoblast myocytes myod myogenesis myogenic myotubes organogenesis overexpressions quiescent regenerated satellite trunk
Tagcloud (Intersection) ?