PRMT5 and SNRPD3

Number of citations of the paper that reports this interaction (PubMedID 11713266)
58

Data Source:
HPRD (in vitro, in vivo)

		PRMT5	SNRPD3
Description		protein arginine methyltransferase 5	small nuclear ribonucleoprotein D3 polypeptide
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex Methylosome Histone Methyltransferase Complex	Commitment Complex Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U7 SnRNP U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Telomerase Holoenzyme Complex Cytoplasm Cytosol Nuclear Body Small Nuclear Ribonucleoprotein Complex Methylosome PICln-Sm Protein Complex SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Ribonucleoprotein Complex
	Molecular Function	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone H4R3 Methyltransferase Activity Protein-containing Complex Binding Protein Heterodimerization Activity E-box Binding Histone H3 Methyltransferase Activity	RNA Binding Protein Binding Enzyme Binding Telomerase RNA Binding Histone Pre-mRNA DCP Binding U7 SnRNA Binding
	Biological Process	Spliceosomal SnRNP Assembly Chromatin Organization Chromatin Remodeling DNA-templated Transcription Termination Regulation Of DNA-templated Transcription Regulation Of Mitotic Nuclear Division Regulation Of Gene Expression Peptidyl-arginine Methylation Methylation Circadian Regulation Of Gene Expression Peptidyl-arginine N-methylation Endothelial Cell Activation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Rhythmic Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing Protein Methylation RNA Splicing 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly
Pathways		snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation	SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)	Acne (severe) ( 24927181) Gamma glutamyl transferase levels ( 32084209)
Interacting Genes		93 interacting genes: ACE2 AIRIM ARGLU1 CACNB2 CALU CAPN1 CDC37 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A DRC4 DUSP14 EIF4A1 EIF4A3 ELOA EPHB6 EZH2 FAM47E FAM76B G3BP2 GLI1 GRHL3 GTPBP2 H2AC20 H2AC4 H3-4 H3-5 H4C1 H4C16 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 KANK2 LDHAL6B LENG8 LNX1 LUC7L MAGEB2 MBP MCRS1 MEF2D MXI1 MYOD1 MYOG NCL NELFCD NTAQ1 OLA1 PDCD4 PDGFRA PHYHIP POLR2A PRPF38A RBFOX2 RBM23 RNF4 RSRP1 SIN3A SLU7 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 SUPT5H TRIB3 TRIM54 TYK2 UBC UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZMYND19 ZNF2 ZNF224 ZNF436 ZUP1	28 interacting genes: CASP8 CEBPA CRY1 DDX20 FNDC3B GEMIN2 GEMIN5 GEMIN6 GEMIN7 IL12RB1 IL7R LSM3 LSM7 NR1I3 NTAQ1 PRMT5 RBL1 SMN1 SMN2 SNRPB SNRPE SNRPG SREK1 STRAP STXBP2 STXBP3 TRDMT1 WDR77
Entrez ID		10419	6634
HPRD ID		04955	03039
Ensembl ID		ENSG00000100462	ENSG00000100028
Uniprot IDs		B4DV00 O14744	P62318
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7BOC 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9E3C 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R	1D3B 3CW1 3JCR 3PGW 3VRI 4PJO 4WZJ 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6V4X 6Y53 6Y5Q 7A5P 7ABG 7ABI 7B0Y 7DVQ 7EVO 7QTT 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8R7N 8RC0 8RM5 8RO2 8Y6O 8Y7E 9FMD 9GBW 9GC0 9GCL
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Methylosome RNA Binding Regulation Of RNA Splicing Regulation Of Metabolic Process U1 SnRNP Binding U1 SnRNP Regulation Of MRNA Splicing, Via Spliceosome Growth Hormone Receptor Binding Regulation Of Transcription By RNA Polymerase II Protein Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane RNA Splicing Spliceosomal Complex Regulation Of MRNA Processing MRNA Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT MRNA Splicing, Via Spliceosome Small Nuclear Ribonucleoprotein Complex Regulation Of MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions PICln-Sm Protein Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Chromosome MRNA Processing Protein Tyrosine Kinase Activity Structural Constituent Of Chromatin Growth Hormone Receptor Signaling Pathway 7-methylguanosine Cap Hypermethylation Protein Localization To Chromatin Protein-RNA Complex Assembly Extrinsic Component Of Plasma Membrane Protein Modification Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process U4 SnRNP Negative Regulation Of Macromolecule Biosynthetic Process	SMN-Sm Protein Complex Spliceosomal SnRNP Assembly SMN Complex Protein-RNA Complex Assembly Gemini Of Cajal Bodies RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing MRNA Metabolic Process RNA Processing Spliceosomal Complex Assembly RNA Metabolic Process Methylosome MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex U2-type Precatalytic Spliceosome RNA Binding Protein-containing Complex Assembly Nucleobase-containing Compound Metabolic Process Nucleoplasm U12-type Spliceosomal Complex Protein-containing Complex Organization U7 SnRNP 7-methylguanosine Cap Hypermethylation Catalytic Step 2 Spliceosome Macromolecule Metabolic Process U4 SnRNP Cellular Component Assembly Macromolecule Methylation Nucleus Nuclear Body Small Nuclear Ribonucleoprotein Complex Cytosol U2 SnRNP Binding U2-type Prespliceosome DNA-templated Transcription Termination U1 SnRNP Precatalytic Spliceosome U5 SnRNP RNA Methylation Tertiary Granule U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Presynaptic Dense Core Vesicle Exocytosis U2-type Catalytic Step 2 Spliceosome Methylation Lsm1-7-Pat1 Complex
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