PRMT5 and EPHB6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRMT5	EPHB6
Description		protein arginine methyltransferase 5	EPH receptor B6
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex Methylosome Histone Methyltransferase Complex	Extracellular Region Cytosol Plasma Membrane Membrane Dendrite
	Molecular Function	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone H4R3 Methyltransferase Activity Protein-containing Complex Binding Protein Heterodimerization Activity E-box Binding Histone H3 Methyltransferase Activity	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Signaling Receptor Activity
	Biological Process	Spliceosomal SnRNP Assembly Chromatin Organization Chromatin Remodeling DNA-templated Transcription Termination Regulation Of DNA-templated Transcription Regulation Of Mitotic Nuclear Division Regulation Of Gene Expression Peptidyl-arginine Methylation Methylation Circadian Regulation Of Gene Expression Peptidyl-arginine N-methylation Endothelial Cell Activation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Rhythmic Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Ephrin Receptor Signaling Pathway
Pathways		snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Cancer ( 29299148)
Interacting Genes		93 interacting genes: ACE2 AIRIM ARGLU1 CACNB2 CALU CAPN1 CDC37 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A DRC4 DUSP14 EIF4A1 EIF4A3 ELOA EPHB6 EZH2 FAM47E FAM76B G3BP2 GLI1 GRHL3 GTPBP2 H2AC20 H2AC4 H3-4 H3-5 H4C1 H4C16 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 KANK2 LDHAL6B LENG8 LNX1 LUC7L MAGEB2 MBP MCRS1 MEF2D MXI1 MYOD1 MYOG NCL NELFCD NTAQ1 OLA1 PDCD4 PDGFRA PHYHIP POLR2A PRPF38A RBFOX2 RBM23 RNF4 RSRP1 SIN3A SLU7 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 SUPT5H TRIB3 TRIM54 TYK2 UBC UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZMYND19 ZNF2 ZNF224 ZNF436 ZUP1	28 interacting genes: AFDN ASB12 CBL CRK CRKL DDIT4L DUSP18 DUSP19 EFNB2 EPHB1 ERBB2 GRB2 HDHD2 INCA1 MSX2 MTARC1 NIF3L1 NOTCH2NLA POU6F2 PRMT5 REL SAT1 STYX TCF4 TEKT5 TRIB3 TRIM39 VPS26C
Entrez ID		10419	2051
HPRD ID		04955	04133
Ensembl ID		ENSG00000100462	ENSG00000106123
Uniprot IDs		B4DV00 O14744	A0A0G2JNH7 F8WCM8 O15197
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7BOC 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9E3C 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R	7K7J
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Methylosome RNA Binding Regulation Of RNA Splicing Regulation Of Metabolic Process U1 SnRNP Binding U1 SnRNP Regulation Of MRNA Splicing, Via Spliceosome Growth Hormone Receptor Binding Regulation Of Transcription By RNA Polymerase II Protein Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane RNA Splicing Spliceosomal Complex Regulation Of MRNA Processing MRNA Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT MRNA Splicing, Via Spliceosome Small Nuclear Ribonucleoprotein Complex Regulation Of MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions PICln-Sm Protein Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Chromosome MRNA Processing Protein Tyrosine Kinase Activity Structural Constituent Of Chromatin Growth Hormone Receptor Signaling Pathway 7-methylguanosine Cap Hypermethylation Protein Localization To Chromatin Protein-RNA Complex Assembly Extrinsic Component Of Plasma Membrane Protein Modification Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process U4 SnRNP Negative Regulation Of Macromolecule Biosynthetic Process	Ephrin Receptor Binding Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Helper T Cell Diapedesis Cerebellar Neuron Development Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Enzyme-linked Receptor Protein Signaling Pathway Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Inhibitor Activity Cellular Response To Growth Factor Stimulus Ephrin Receptor Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Adhesion Postsynaptic Specialization Assembly Response To Growth Factor Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Positive Regulation Of Small GTPase Mediated Signal Transduction Neuromuscular Junction Cerebral Cortex Development Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Schwann Cell Development Protein Tyrosine/serine/threonine Phosphatase Activity Establishment Of Cell Polarity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Postsynaptic Specialization Organization SH3 Domain Binding Neuron Projection Development Regulation Of Protein Serine/threonine Kinase Activity Cytoplasm Signal Transduction Protein Binding Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Adhesion Regulation Of Rac Protein Signal Transduction T Cell Migration Identical Protein Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Spermidine Binding
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