PRMT5 and SUPT5H

Number of citations of the paper that reports this interaction (PubMedID 12718890)
0

Data Source:
HPRD (in vitro, in vivo)

		PRMT5	SUPT5H
Description		protein arginine methyltransferase 5	SPT5 homolog, DSIF elongation factor subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex Methylosome Histone Methyltransferase Complex	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone H4R3 Methyltransferase Activity Protein-containing Complex Binding Protein Heterodimerization Activity E-box Binding Histone H3 Methyltransferase Activity	Chromatin Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Spliceosomal SnRNP Assembly Chromatin Organization Chromatin Remodeling DNA-templated Transcription Termination Regulation Of DNA-templated Transcription Regulation Of Mitotic Nuclear Division Regulation Of Gene Expression Peptidyl-arginine Methylation Methylation Circadian Regulation Of Gene Expression Peptidyl-arginine N-methylation Endothelial Cell Activation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Rhythmic Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Positive Regulation Of Macroautophagy Regulation Of DNA-templated Transcription Elongation Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)	Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		93 interacting genes: ACE2 AIRIM ARGLU1 CACNB2 CALU CAPN1 CDC37 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A DRC4 DUSP14 EIF4A1 EIF4A3 ELOA EPHB6 EZH2 FAM47E FAM76B G3BP2 GLI1 GRHL3 GTPBP2 H2AC20 H2AC4 H3-4 H3-5 H4C1 H4C16 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 KANK2 LDHAL6B LENG8 LNX1 LUC7L MAGEB2 MBP MCRS1 MEF2D MXI1 MYOD1 MYOG NCL NELFCD NTAQ1 OLA1 PDCD4 PDGFRA PHYHIP POLR2A PRPF38A RBFOX2 RBM23 RNF4 RSRP1 SIN3A SLU7 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 SUPT5H TRIB3 TRIM54 TYK2 UBC UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZMYND19 ZNF2 ZNF224 ZNF436 ZUP1	51 interacting genes: C9orf78 CCNH CCNT2 CDK7 CDK9 CEP55 CPSF7 CSNK2A1 DBN1 DCAF6 DSCAM EXOSC7 FHL3 GOLGA2 GTF3C1 H2AX HSPB1 HTATSF1 IK IKBKG LMAN2 MAD1L1 MAML3 MNAT1 PCBD1 PGK1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 RPL9 SAP30BP SIK1 SNRNP48 SNX4 SSBP3 SUMO2 SUPT4H1 TERF1 TEX11 TLE5 XRCC5 YBX2 ZBTB3 ZFYVE9 ZNF496 ZNF512B
Entrez ID		10419	6829
HPRD ID		04955	03655
Ensembl ID		ENSG00000100462	ENSG00000196235
Uniprot IDs		B4DV00 O14744	O00267
PDB IDs		4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7BOC 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9E3C 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R	2DO3 2E6Z 2E70 3H7H 4L1U 5OHO 5OHQ 5OIK 5U98 6EQY 6ER0 6GMH 6GML 6TED 7OKX 7OKY 7OL0 7PKS 7UNC 7UND 7YCX 8A3Y 8P4C 8P4D 8P4E 8P4F 8RBX 8UHA 8UHD 8UHG 8UI0 8UIS 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH2 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Methylosome RNA Binding Regulation Of RNA Splicing Regulation Of Metabolic Process U1 SnRNP Binding U1 SnRNP Regulation Of MRNA Splicing, Via Spliceosome Growth Hormone Receptor Binding Regulation Of Transcription By RNA Polymerase II Protein Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane RNA Splicing Spliceosomal Complex Regulation Of MRNA Processing MRNA Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT MRNA Splicing, Via Spliceosome Small Nuclear Ribonucleoprotein Complex Regulation Of MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions PICln-Sm Protein Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Chromosome MRNA Processing Protein Tyrosine Kinase Activity Structural Constituent Of Chromatin Growth Hormone Receptor Signaling Pathway 7-methylguanosine Cap Hypermethylation Protein Localization To Chromatin Protein-RNA Complex Assembly Extrinsic Component Of Plasma Membrane Protein Modification Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process U4 SnRNP Negative Regulation Of Macromolecule Biosynthetic Process	Nucleus Nucleic Acid Metabolic Process Transcription Factor TFIIK Complex CAK-ERCC2 Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process DNA-templated Transcription Initiation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Nucleobase-containing Compound Biosynthetic Process Regulation Of Gene Expression Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Elongation Protein Peptidyl-prolyl Isomerization Chromosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Chromosome Segregation DNA Metabolic Process Recombinational Repair Protein Localization To Site Of Double-strand Break Protein Binding DNA Recombination Transcription Pausing By RNA Polymerase II Postsynaptic Cytosol Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anoikis Regulation Of Transcription Elongation By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling Macromolecule Biosynthetic Process
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