PRMT5 and LUC7L

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PRMT5	LUC7L
Gene Name		protein arginine methyltransferase 5	LUC7-like (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome	U1 SnRNP
	Molecular Function	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Ribonucleoprotein Complex Binding	MRNA Binding Protein Binding Identical Protein Binding RS Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Cell Proliferation Gene Expression Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression NcRNA Metabolic Process Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation	MRNA Splice Site Selection Negative Regulation Of Striated Muscle Tissue Development
Pathways		Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 20139978)
Protein-Protein Interactions		67 interactors: ARGLU1 CALU CAPN1 CCAR2 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A EZH2 FAM76B GRHL3 GTPBP2 H3F3C HIST1H3A HIST1H4A HIST2H2AC HOXC4 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NELFCD NUDCD2 OLA1 PHYHIP PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SSTR1 SUPT5H TRIB3 TYK2 WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUFSP	11 interactors: CALM1 CHERP CTNNBL1 FAM173A FBXO25 GADD45G PRDX1 PRMT5 SRPK1 SRPK2 TCERG1
Entrez ID		10419	55692
HPRD ID		04955	08476
Ensembl ID		ENSG00000100462	ENSG00000007392
Uniprot IDs		O14744	D3DU41 Q1W6G4 Q9NQ29
PDB IDs		4GQB
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Chromatin Modification Regulation Of RNA Metabolic Process MRNA Processing Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated MRNA Metabolic Process RNA Splicing RNA Biosynthetic Process RNA Processing Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Transcription, DNA-templated MRNA Splicing, Via Spliceosome Regulation Of Nucleic Acid-templated Transcription RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Biogenesis Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Peptidyl-amino Acid Modification Positive Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Chromatin Remodeling Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process	RNA Processing RNA Splicing MRNA Processing Positive Regulation Of Viral Genome Replication MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Regulation Of Cell Cycle Positive Regulation Of Viral Process Nuclear Speck Organization Negative Regulation Of Viral Process Regulation Of MRNA Processing Regulation Of Transcription Factor Import Into Nucleus Regulation Of Intracellular Transport RNA Metabolic Process Regulation Of RNA Splicing Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Reactive Oxygen Species Metabolic Process Immune System Process Nucleus Organization Gene Expression Immune Response Defense Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Cell Death Regulation Of Viral Process Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Ion Homeostasis Developmental Process Nitrogen Compound Metabolic Process Regulation Of Protein Import Into Nucleus Ribonucleoprotein Complex Assembly Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Stress-activated MAPK Cascade Cellular Metabolic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Nucleocytoplasmic Transport Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Sperm Chromatin Condensation Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cell Division
Tagcloud ?		acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Difference) ?		acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Intersection) ?