TLR2 and TLR6

Number of citations of the paper that reports this interaction (PMID 12077222)
213

Data Source:
HPRD (in vivo)

		TLR2	TLR6
Gene Name		toll-like receptor 2	toll-like receptor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Cell Projection Cell Body	Plasma Membrane Integral Component Of Plasma Membrane Phagocytic Vesicle Membrane Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex
	Molecular Function	Lipopolysaccharide Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Signaling Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Diacyl Lipopeptide Binding Peptidoglycan Binding Protein Heterodimerization Activity Lipoteichoic Acid Binding	Receptor Activity Transmembrane Signaling Receptor Activity Diacyl Lipopeptide Binding Protein Heterodimerization Activity Lipopeptide Binding
	Biological Process	Response To Hypoxia Microglial Cell Activation Toll-like Receptor Signaling Pathway Response To Molecule Of Fungal Origin Positive Regulation Of Leukocyte Migration Cell Surface Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction I-kappaB Phosphorylation Negative Regulation Of Cell Proliferation Response To Toxic Substance Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Central Nervous System Myelin Formation Response To Progesterone Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Chloramphenicol Transport Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitric Oxide Metabolic Process Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Induction By Symbiont Of Defense-related Host Nitric Oxide Production Positive Regulation Of Macrophage Cytokine Production Response To Fatty Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 6 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway T-helper 1 Type Immune Response Detection Of Diacyl Bacterial Lipopeptide Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Diacyl Bacterial Lipopeptide
Pathways		Toll Like Receptor 2 (TLR2) Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Beta defensins MyD88:Mal cascade initiated on plasma membrane Defensins Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System	Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System
Drugs		OspA lipoprotein S-(Dimethylarsenic)Cysteine
Diseases
GWAS			Helicobacter pylori serologic status ( 23652523)
Protein-Protein Interactions		18 interactors: CD14 HMGB1 HRAS HSP90B1 IRAK1 LY96 MAPK8IP3 MYD88 PIK3R1 RAC1 RIPK2 TICAM1 TIRAP TLR1 TLR10 TLR6 TOLLIP TRIP6	3 interactors: BTK TLR2 TRAP1
Entrez ID		7097	10333
HPRD ID		04323	05656
Ensembl ID			ENSG00000174130
Uniprot IDs		B3KWR9 O60603	B2R933 Q9Y2C9
PDB IDs		1FYW 1FYX 1O77 2Z7X 2Z80
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Defense Response Regulation Of Innate Immune Response Inflammatory Response Regulation Of Immune Response Positive Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Tumor Necrosis Factor Production Response To Molecule Of Bacterial Origin Intracellular Signal Transduction Regulation Of Cytokine Production I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-6 Production Positive Regulation Of Signal Transduction Response To External Stimulus Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Signal Transduction Cellular Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Signaling Cell Communication Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Other Organism	Response To Molecule Of Fungal Origin Response To Fungus I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Reactive Oxygen Species Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Chloramphenicol Transport Regulation Of B Cell Cytokine Production Induction By Symbiont Of Defense-related Host Nitric Oxide Production Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Innate Immune Response Cellular Response To Molecule Of Fungal Origin Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Response To Defense-related Host Nitric Oxide Production Positive Regulation Of Interleukin-18 Production Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Cellular Respiration Immune Response-activating Cell Surface Receptor Signaling Pathway Detection Of Diacyl Bacterial Lipopeptide Detection Of Triacyl Bacterial Lipopeptide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Antibiotic Transport Central Nervous System Myelin Formation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Peptidoglycan Response To Host Immune Response Inflammatory Response Detection Of Bacterial Lipoprotein Immune Response-regulating Signaling Pathway Leukocyte Activation Negative Regulation Of Interleukin-17 Production Cellular Response To Bacterial Lipopeptide Regulation Of Cytokine Production Positive Regulation Of Toll-like Receptor Signaling Pathway Histamine Secretion By Mast Cell Response To Peptidoglycan Regulation Of Cellular Respiration Microglial Cell Activation
Tagcloud ?		1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy hmgb1 index mobility pbmcs rage remarkably spondylitis surface tlr4 untreated	advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tollip tuberculin uganda
Tagcloud (Difference) ?		1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy hmgb1 index mobility pbmcs rage remarkably spondylitis surface untreated	advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tollip tuberculin uganda
Tagcloud (Intersection) ?		tlr4