TLR2 and LY96

Number of citations of the paper that reports this interaction (PMID 11160242)
38

Data Source:
HPRD (in vivo)

		TLR2	LY96
Gene Name		toll-like receptor 2	lymphocyte antigen 96
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Cell Projection Cell Body	Extracellular Space Plasma Membrane Endosome Membrane Lipopolysaccharide Receptor Complex
	Molecular Function	Lipopolysaccharide Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Signaling Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Diacyl Lipopeptide Binding Peptidoglycan Binding Protein Heterodimerization Activity Lipoteichoic Acid Binding	Lipopolysaccharide Receptor Activity Protein Binding Coreceptor Activity
	Biological Process	Response To Hypoxia Microglial Cell Activation Toll-like Receptor Signaling Pathway Response To Molecule Of Fungal Origin Positive Regulation Of Leukocyte Migration Cell Surface Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction I-kappaB Phosphorylation Negative Regulation Of Cell Proliferation Response To Toxic Substance Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Central Nervous System Myelin Formation Response To Progesterone Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Chloramphenicol Transport Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitric Oxide Metabolic Process Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Induction By Symbiont Of Defense-related Host Nitric Oxide Production Positive Regulation Of Macrophage Cytokine Production Response To Fatty Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Cellular Defense Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response
Pathways		Toll Like Receptor 2 (TLR2) Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Beta defensins MyD88:Mal cascade initiated on plasma membrane Defensins Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System	TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88:Mal cascade initiated on plasma membrane TRIF-mediated programmed cell death Innate Immune System
Drugs		OspA lipoprotein S-(Dimethylarsenic)Cysteine
Diseases
GWAS
Protein-Protein Interactions		18 interactors: CD14 HMGB1 HRAS HSP90B1 IRAK1 LY96 MAPK8IP3 MYD88 PIK3R1 RAC1 RIPK2 TICAM1 TIRAP TLR1 TLR10 TLR6 TOLLIP TRIP6	4 interactors: CALM1 CDKN2C TLR2 TLR4
Entrez ID		7097	23643
HPRD ID		04323	05579
Ensembl ID			ENSG00000154589
Uniprot IDs		B3KWR9 O60603	E5RJJ7 Q9Y6Y9
PDB IDs		1FYW 1FYX 1O77 2Z7X 2Z80	1T2Z 2E56 2E59 2Z65 3FXI 3ULA 4G8A
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Defense Response Regulation Of Innate Immune Response Inflammatory Response Regulation Of Immune Response Positive Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Tumor Necrosis Factor Production Response To Molecule Of Bacterial Origin Intracellular Signal Transduction Regulation Of Cytokine Production I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-6 Production Positive Regulation Of Signal Transduction Response To External Stimulus Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Signal Transduction Cellular Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Signaling Cell Communication Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Other Organism	Negative Regulation Of Interleukin-17 Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process I-kappaB Phosphorylation Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Interferon-beta Production Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Nitric Oxide Metabolic Process Detection Of Biotic Stimulus Macrophage Activation Positive Regulation Of Interleukin-10 Production Reactive Nitrogen Species Metabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Response To Fungus Regulation Of Interferon-beta Production Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Nitric Oxide Biosynthetic Process Detection Of Chemical Stimulus Positive Regulation Of Chemokine Production Negative Regulation Of Phosphorylation Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-12 Production Regulation Of Intracellular Transport Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Signaling Pathway Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Detection Of Stimulus Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Type I Interferon Production Oligodendrocyte Differentiation Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?		1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy hmgb1 index mobility pbmcs rage remarkably spondylitis surface tlr4 untreated	8v2 bad bead chips corrected ctla4 error false fdr genespring humanref hybridized il8 illumina inflation ingenuity institutes ipa mrs paxgene prove rankin recovery sdpr stroke tlr2 tlr4 tubes validation
Tagcloud (Difference) ?		1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy hmgb1 index mobility pbmcs rage remarkably spondylitis surface untreated	8v2 bad bead chips corrected ctla4 error false fdr genespring humanref hybridized il8 illumina inflation ingenuity institutes ipa mrs paxgene prove rankin recovery sdpr stroke tubes validation
Tagcloud (Intersection) ?		tlr2 tlr4