TLR2 and LY96

Number of citations of the paper that reports this interaction (PubMedID 11160242)
0

Data Source:
HPRD (in vivo)

		TLR2	LY96
Description		toll like receptor 2	lymphocyte antigen 96
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft	Extracellular Region Plasma Membrane Endosome Membrane Receptor Complex Lipopolysaccharide Receptor Complex
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Lipopolysaccharide Immune Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Identical Protein Binding Peptidoglycan Binding Protein-containing Complex Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity Protein Binding Coreceptor Activity Toll-like Receptor 4 Binding
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction Learning Positive Regulation Of Gene Expression Microglia Development Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Negative Regulation Of Synapse Assembly Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Type II Interferon Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion	Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Cellular Defense Response Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Response To Lipopolysaccharide
Pathways		ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Modulation by Mtb of host immune system SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions	ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex Heme signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions
Drugs		Lyme disease vaccine (recombinant OspA) Adapalene S-(Dimethylarsenic)Cysteine Golotimod Tuberculin purified protein derivative Pam2csk4	Morphine (R)-3-hydroxytetradecanoic acid Lauric acid Myristic acid
Diseases
GWAS		Body fat mass ( 28552196)	Carotid plaque burden (smoking interaction) ( 24954085) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Liver enzyme levels (alkaline phosphatase) ( 33972514) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043)
Interacting Genes		29 interacting genes: AKT1 ANP32B CD14 EGFR FBP1 HEMGN HMGB1 HRAS HSP90B1 IRAK1 LY96 MAP2K1 MAPK8IP3 MYD88 NANS PIK3R1 RAC1 RIPK2 SMAD1 STX17 TGFB1 TICAM1 TIRAP TLR1 TLR10 TLR6 TMOD1 TOLLIP TRIP6	8 interacting genes: CALM1 CDKN2C LCN2 MESD MLH1 SMARCB1 TLR2 TLR4
Entrez ID		7097	23643
HPRD ID		04323	05579
Ensembl ID		ENSG00000137462	ENSG00000154589
Uniprot IDs		A0A0S2Z4S4 B3KWR9 O60603	Q9Y6Y9
PDB IDs		1FYW 1FYX 1O77 2Z7X 2Z80 6NIG 8AR0	2E56 2E59 2Z65 3FXI 3ULA 4G8A 8WO1 8WTA
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Innate Immune Response Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Activation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Molecule Of Bacterial Origin Defense Response Immune Response-activating Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Cytokine Production Regulation Of Defense Response Immune Response-regulating Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Cellular Response To Bacterial Lipopeptide Toll-like Receptor 2 Binding Response To Lipid Response To Bacterial Lipoprotein Positive Regulation Of Gene Expression Innate Immune Response Regulation Of Cytokine Production Response To Stress Response To External Biotic Stimulus Regulation Of Immune System Process Response To Other Organism Defense Response To Symbiont Cellular Response To Lipid Immune Response Regulation Of Interleukin-6 Production Regulation Of Signal Transduction	Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Type II Interferon Lipopolysaccharide Immune Receptor Activity Positive Regulation Of Gene Expression Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Lipoteichoic Acid Response To Type II Interferon Detection Of Molecule Of Bacterial Origin Detection Of Chemical Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Cytokine Stimulus Response To Cytokine Cellular Response To Molecule Of Bacterial Origin Detection Of Biotic Stimulus Response To Peptide Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-12 Production Detection Of Stimulus Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Cellular Response To Amyloid-beta Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hippocampal Neuron Apoptotic Process Defense Response To Bacterium Response To Amyloid-beta B Cell Activation Involved In Immune Response Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Glial Cell Development Regulation Of Interleukin-12 Production Triacyl Lipopeptide Binding Positive Regulation Of Interleukin-8 Production Regulation Of Interferon-beta Production Nitric Oxide Production Involved In Inflammatory Response Response To Molecule Of Bacterial Origin Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lymphocyte Activation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication
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