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TLR2 and MYD88
Number of citations of the paper that reports this interaction (PubMedID
16482509
)
45
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
TLR2
MYD88
Description
toll like receptor 2
MYD88 innate immune signal transduction adaptor
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Surface
Membrane
Secretory Granule Membrane
Phagocytic Vesicle Membrane
Cytoplasmic Vesicle
Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex
Receptor Complex
Membrane Raft
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell Surface
Endosome Membrane
Extrinsic Component Of Plasma Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Protein-containing Complex
Molecular Function
Lipopolysaccharide Binding
Amyloid-beta Binding
Lipopolysaccharide Immune Receptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Toll-like Receptor Binding
Signaling Receptor Activity
Pattern Recognition Receptor Activity
Triacyl Lipopeptide Binding
Identical Protein Binding
Peptidoglycan Binding
Protein-containing Complex Binding
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
Signaling Receptor Binding
Toll Binding
Death Receptor Binding
Cytokine Receptor Binding
Interleukin-1 Receptor Binding
Protein Binding
Toll-like Receptor Binding
Signaling Adaptor Activity
Identical Protein Binding
Molecular Adaptor Activity
TIR Domain Binding
ATP-dependent Histone Chaperone Activity
Biological Process
Toll-like Receptor Signaling Pathway
Immune System Process
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
Learning
Positive Regulation Of Gene Expression
Microglia Development
Positive Regulation Of Wnt Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Detection Of Triacyl Bacterial Lipopeptide
Detection Of Diacyl Bacterial Lipopeptide
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
Negative Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Negative Regulation Of Synapse Assembly
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Cellular Response To Type II Interferon
Cellular Response To Diacyl Bacterial Lipopeptide
Cellular Response To Triacyl Bacterial Lipopeptide
Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Matrix Metallopeptidase Secretion
Response To Molecule Of Fungal Origin
Leukocyte Activation Involved In Inflammatory Response
Neutrophil Activation Involved In Immune Response
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Chromatin Organization
Chromatin Remodeling
Phagocytosis
Apoptotic Process
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
JNK Cascade
Toll Signaling Pathway
Response To Virus
Induced Systemic Resistance
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Microglia Differentiation
Response To Amine
Immunoglobulin Mediated Immune Response
Cytokine-mediated Signaling Pathway
Neurogenesis
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Peptidoglycan
Response To Lipopolysaccharide
Regulation Of Interleukin-6 Production
Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 4 Signaling Pathway
Regulation Of Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 8 Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Defense Response To Bacterium
Defense Response To Protozoan
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Skin Development
Innate Immune Response
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Macrophage Cytokine Production
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
3'-UTR-mediated MRNA Stabilization
Neutrophil-mediated Killing Of Bacterium
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Establishment Of Endothelial Intestinal Barrier
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Regulation Of Neutrophil Migration
Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
ER-Phagosome pathway
Beta defensins
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Modulation by Mtb of host immune system
SARS-CoV-2 activates/modulates innate and adaptive immune responses
RSV-host interactions
ER-Phagosome pathway
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
RIP-mediated NFkB activation via ZBP1
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
MyD88 deficiency (TLR2/4)
MyD88 deficiency (TLR5)
IRAK4 deficiency (TLR5)
IRAK4 deficiency (TLR2/4)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
Lyme disease vaccine (recombinant OspA)
Adapalene
S-(Dimethylarsenic)Cysteine
Golotimod
Tuberculin purified protein derivative
Pam2csk4
Diseases
GWAS
Body fat mass (
28552196
)
Gut microbiota (bacterial taxa) (
27723756
)
Mean corpuscular hemoglobin concentration (
29403010
)
Interacting Genes
29 interacting genes:
AKT1
ANP32B
CD14
EGFR
FBP1
HEMGN
HMGB1
HRAS
HSP90B1
IRAK1
LY96
MAP2K1
MAPK8IP3
MYD88
NANS
PIK3R1
RAC1
RIPK2
SMAD1
STX17
TGFB1
TICAM1
TIRAP
TLR1
TLR10
TLR6
TMOD1
TOLLIP
TRIP6
44 interacting genes:
BTK
CD93
CISH
FADD
FLII
IKBKG
IL1R1
IL1RAP
IL1RL1
IRAK1
IRAK2
IRAK3
IRAK4
IRF4
IRF5
IRF7
MAL
MBIP
MDM2
NTAQ1
PELI2
PFKL
POLR1C
PRDX1
RAC1
RNF152
RNF4
SARM1
SIAH2
SMAD3
SPOP
SPOPL
STAP2
TIRAP
TLR10
TLR2
TLR3
TLR4
TLR5
TLR7
TLR8
TXN
USP7
ZNF35
Entrez ID
7097
4615
HPRD ID
04323
03703
Ensembl ID
ENSG00000137462
ENSG00000172936
Uniprot IDs
A0A0S2Z4S4
B3KWR9
O60603
A0A0A0MSI9
A0A3B3ITY3
A0A3F2YP85
A0A494C0J8
Q99836
PDB IDs
1FYW
1FYX
1O77
2Z7X
2Z80
6NIG
8AR0
2JS7
2Z5V
3MOP
4DOM
4EO7
6I3N
7BEQ
7BER
7L6W
8S78
8W8M
Enriched GO Terms of Interacting Partners
?
Regulation Of Innate Immune Response
Activation Of Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Inflammatory Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 4 Signaling Pathway
Regulation Of Tumor Necrosis Factor Production
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Defense Response
Cell Surface Toll-like Receptor Signaling Pathway
Cellular Response To Molecule Of Bacterial Origin
Positive Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Immune Response
Positive Regulation Of Immune System Process
Activation Of Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Response To Molecule Of Bacterial Origin
Defense Response
Immune Response-activating Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Positive Regulation Of Cytokine Production
Regulation Of Defense Response
Immune Response-regulating Signaling Pathway
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Intracellular Signal Transduction
Defense Response To Other Organism
Cellular Response To Bacterial Lipopeptide
Toll-like Receptor 2 Binding
Response To Lipid
Response To Bacterial Lipoprotein
Positive Regulation Of Gene Expression
Innate Immune Response
Regulation Of Cytokine Production
Response To Stress
Response To External Biotic Stimulus
Regulation Of Immune System Process
Response To Other Organism
Defense Response To Symbiont
Cellular Response To Lipid
Immune Response
Regulation Of Interleukin-6 Production
Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Activation Of Innate Immune Response
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Defense Response
Positive Regulation Of Cytokine Production
Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Positive Regulation Of Defense Response
Regulation Of Canonical NF-kappaB Signal Transduction
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
MyD88-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response
Defense Response To Other Organism
Positive Regulation Of Immune Response
Defense Response
Positive Regulation Of Gene Expression
Regulation Of Cytokine Production
Response To Other Organism
Defense Response To Symbiont
Response To External Biotic Stimulus
Positive Regulation Of Immune System Process
Immune System Process
Immune Response
Regulation Of Immune System Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Regulation Of Signal Transduction
Regulation Of Interferon-beta Production
Inflammatory Response
Positive Regulation Of Interleukin-8 Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Interferon-beta Production
Cell Surface Toll-like Receptor Signaling Pathway
Response To Stress
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Interleukin-8 Production
Interleukin-1-mediated Signaling Pathway
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