TLR2 and RIPK2

Number of citations of the paper that reports this interaction (PMID 11894098)
181

Data Source:
HPRD (in vivo)

		TLR2	RIPK2
Gene Name		toll-like receptor 2	receptor-interacting serine-threonine kinase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Cell Projection Cell Body	Cytoplasm Cytosol Cytoskeleton Vesicle Protein Complex
	Molecular Function	Lipopolysaccharide Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Signaling Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Diacyl Lipopeptide Binding Peptidoglycan Binding Protein Heterodimerization Activity Lipoteichoic Acid Binding	Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding LIM Domain Binding Protein Homodimerization Activity CARD Domain Binding
	Biological Process	Response To Hypoxia Microglial Cell Activation Toll-like Receptor Signaling Pathway Response To Molecule Of Fungal Origin Positive Regulation Of Leukocyte Migration Cell Surface Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction I-kappaB Phosphorylation Negative Regulation Of Cell Proliferation Response To Toxic Substance Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Central Nervous System Myelin Formation Response To Progesterone Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Chloramphenicol Transport Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitric Oxide Metabolic Process Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Induction By Symbiont Of Defense-related Host Nitric Oxide Production Positive Regulation Of Macrophage Cytokine Production Response To Fatty Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide	Activation Of MAPK Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Adaptive Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Inflammatory Response Signal Transduction I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Positive Regulation Of Alpha-beta T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Response To Interleukin-1 Response To Interleukin-12 Response To Interleukin-18 Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide
Pathways		Toll Like Receptor 2 (TLR2) Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Beta defensins MyD88:Mal cascade initiated on plasma membrane Defensins Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System	Downstream TCR signaling p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 activated TAK1 mediates p38 MAPK activation Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs		OspA lipoprotein S-(Dimethylarsenic)Cysteine
Diseases
GWAS			Cognitive performance ( 20125193) Crohn's disease ( 23128233) Leprosy ( 20018961)
Protein-Protein Interactions		18 interactors: CD14 HMGB1 HRAS HSP90B1 IRAK1 LY96 MAPK8IP3 MYD88 PIK3R1 RAC1 RIPK2 TICAM1 TIRAP TLR1 TLR10 TLR6 TOLLIP TRIP6	31 interactors: BCL10 BIRC2 BIRC3 CARD16 CARD6 CASP1 CASP8 CD40 CFLAR CHUK IKBKG IRAK1 KDM3A LRRK2 MAVS NGFR NOD1 NOD2 PELI3 PRMT2 SMAD4 SMURF1 TLR2 TLR4 TNFRSF1A TRAF1 TRAF2 TRAF5 TRAF6 UBE2I XIAP
Entrez ID		7097	8767
HPRD ID		04323	04585
Ensembl ID			ENSG00000104312
Uniprot IDs		B3KWR9 O60603	O43353
PDB IDs		1FYW 1FYX 1O77 2Z7X 2Z80
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Defense Response Regulation Of Innate Immune Response Inflammatory Response Regulation Of Immune Response Positive Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Tumor Necrosis Factor Production Response To Molecule Of Bacterial Origin Intracellular Signal Transduction Regulation Of Cytokine Production I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-6 Production Positive Regulation Of Signal Transduction Response To External Stimulus Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Signal Transduction Cellular Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Signaling Cell Communication Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Other Organism	Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Signal Transduction Regulation Of Cell Death Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Apoptotic Process Regulation Of Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cytokine Production Cell Death Death Positive Regulation Of Cellular Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cytokine Production Response To Bacterium Apoptotic Process Positive Regulation Of Immune Response Programmed Cell Death Regulation Of Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Other Organism Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Defense Response Response To Biotic Stimulus Positive Regulation Of Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Negative Regulation Of Cell Death Toll-like Receptor 2 Signaling Pathway Innate Immune Response
Tagcloud ?		1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy hmgb1 index mobility pbmcs rage remarkably spondylitis surface tlr4 untreated	altogether appealing approved arthritis bowel conjunction crohn diagnostics drastically excessive fda gefitinib ibd ileitis improves nod1 nod2 optimization peptidoglycan peritonitis pharmaceuticals pharmacologic potently predicting productive rationale sarcoidosis sensors transduces
Tagcloud (Difference) ?		1racp abilities analysed ankylosing asdas basdai basfi bath besides box chromosomal compare correlations crp elisa erythrocytesedimentationrate esr from71 healthy hmgb1 index mobility pbmcs rage remarkably spondylitis surface tlr4 untreated	altogether appealing approved arthritis bowel conjunction crohn diagnostics drastically excessive fda gefitinib ibd ileitis improves nod1 nod2 optimization peptidoglycan peritonitis pharmaceuticals pharmacologic potently predicting productive rationale sarcoidosis sensors transduces
Tagcloud (Intersection) ?