KHDRBS3 and RFC3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		KHDRBS3	RFC3
Name		KH RNA binding domain containing, signal transduction associated 3	replication factor C subunit 3
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Protein-containing Complex	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex Protein-containing Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding SH3 Domain Binding Protein Domain Specific Binding Identical Protein Binding	DNA Binding DNA Clamp Loader Activity Protein Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		PTK6 Regulates Proteins Involved in RNA Processing	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
GWAS		Chronotype ( 30696823 ) Colorectal cancer ( 34062886 ) Disease progression in age-related macular degeneration ( 29346644 ) Polycystic ovary syndrome ( 25574032 ) Squamous cell lung carcinoma ( 28604730 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )	Alzheimer's disease ( 20061627 ) Colorectal cancer or advanced adenoma ( 30510241 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Obesity-related traits ( 23251661 )
Interacting Genes		59 interacting genes: AQP1 BAHD1 CACNA1A CCDC187 CCDC33 CNNM3 CPSF7 DMRT3 DOCK2 FBXO7 FUS FXR1 HBZ HNRNPC HNRNPK HNRNPR INPP5D KHDRBS1 KHDRBS2 LMNTD2 LNX1 MARK4 MYPOP NCOA5 NELFB NUDT18 OGT PCDHB14 PPP1R13B PRMT1 PRPF31 PRR3 PSMA1 PSMF1 PTBP2 RASAL3 RASD1 RBBP6 RBM3 RBM7 RBMX RBMY1A1 RFC3 RPH3AL SGSM2 SIAH1 SNRPC SNX18 SRSF9 TSGA10IP TYK2 U2AF2 WWP2 YTHDC1 ZNF326 ZNF408 ZNF575 ZNF580 ZNF688	14 interacting genes: ANKRD40 ARFGAP1 CEBPA CHTF8 INCA1 KHDRBS2 KHDRBS3 MESD PCNA PICK1 PTEN RAD17 RFC1 RFC4
Entrez ID		10656	5983
HPRD ID		10007	02676
Ensembl ID		ENSG00000131773	ENSG00000133119
Uniprot IDs		O75525	P40938
PDB IDs		5EL3 5ELR 5ELS 5ELT 5EMO	6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
GO Terms Enriched among Interactors		Regulation Of RNA Splicing MRNA Processing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing Regulation Of MRNA Processing RNA Processing MRNA Binding RNA Binding Regulation Of MRNA Metabolic Process MRNA Metabolic Process Spliceosomal Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Poly(U) RNA Binding Protein-RNA Complex Assembly MRNA Alternative Polyadenylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Commitment Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleoplasm Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Translation Catalytic Step 2 Spliceosome Protein-containing Complex Assembly Positive Regulation Of NK T Cell Activation Protein Binding	DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Elg1 RFC-like Complex Positive Regulation Of DNA Biosynthetic Process DNA Replication DNA Replication Factor C Complex Ctf18 RFC-like Complex Protein Domain Specific Binding Regulation Of DNA Biosynthetic Process Nucleic Acid Metabolic Process DNA Strand Elongation Involved In DNA Replication Single-stranded DNA Helicase Activity DNA Strand Elongation Negative Regulation Of Cell Cycle Nucleoplasm Identical Protein Binding DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Dendritic Spine Organization Response To Dexamethasone Regulation Of DNA Metabolic Process Neuron Projection Organization Postsynapse Organization DNA Repair Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding PCNA Complex Replisome Negative Regulation Of Synaptic Vesicle Clustering Rad17 RFC-like Complex DNA-templated DNA Replication Regulation Of Catalytic Activity Cellular Response To Stress Animal Organ Regeneration Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Vitamin B2 C/EBP Complex PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Positive Regulation Of DNA Metabolic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA Clamp Unloader Activity Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Catalytic Activity