KHDRBS3 and RPH3AL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KHDRBS3	RPH3AL
Description		KH RNA binding domain containing, signal transduction associated 3	rabphilin 3A like (without C2 domains)
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Protein-containing Complex	Cytoplasm Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Synapse Presynapse
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding SH3 Domain Binding Protein Domain Specific Binding Identical Protein Binding	Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome	Intracellular Protein Transport Exocytosis G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Secretion Glucose Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion
Pathways		PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Diseases
GWAS		Chronotype ( 30696823) Colorectal cancer ( 34062886) Disease progression in age-related macular degeneration ( 29346644) Polycystic ovary syndrome ( 25574032) Squamous cell lung carcinoma ( 28604730) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	AIDS progression ( 21502085) DHEAS levels ( 34748635) Dimensional psychopathology (Cognitive) ( 29496196) Idiopathic intracranial hypertension ( 29608535) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001)
Interacting Genes		59 interacting genes: AQP1 BAHD1 CACNA1A CCDC187 CCDC33 CNNM3 CPSF7 DMRT3 DOCK2 FBXO7 FUS FXR1 HBZ HNRNPC HNRNPK HNRNPR INPP5D KHDRBS1 KHDRBS2 LMNTD2 LNX1 MARK4 MYPOP NCOA5 NELFB NUDT18 OGT PCDHB14 PPP1R13B PRMT1 PRPF31 PRR3 PSMA1 PSMF1 PTBP2 RASAL3 RASD1 RBBP6 RBM3 RBM7 RBMX RBMY1A1 RFC3 RPH3AL SGSM2 SIAH1 SNRPC SNX18 SRSF9 TSGA10IP TYK2 U2AF2 WWP2 YTHDC1 ZNF326 ZNF408 ZNF575 ZNF580 ZNF688	26 interacting genes: AIRIM ANKRD11 ATPAF2 HNRNPK KHDRBS3 MID2 MYO15B PNMA3 PRKAB2 PSME3 RAB27A RAB27B RAB3A RAB3B RAB3C RAB3D RAB3GAP1 RAB8A RIMS2 RSPH14 SAAL1 SCNM1 SNCA TCEA3 UNC13B ZYX
Entrez ID		10656	9501
HPRD ID		10007	05345
Ensembl ID		ENSG00000131773	ENSG00000181031
Uniprot IDs		O75525	A8K7D5 Q9UNE2
PDB IDs		5EL3 5ELR 5ELS 5ELT 5EMO
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing MRNA Processing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing Regulation Of MRNA Processing RNA Processing MRNA Binding RNA Binding Regulation Of MRNA Metabolic Process MRNA Metabolic Process Spliceosomal Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Negative Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Poly(U) RNA Binding Protein-RNA Complex Assembly MRNA Alternative Polyadenylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Commitment Complex Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleoplasm Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Translation Catalytic Step 2 Spliceosome Protein-containing Complex Assembly Positive Regulation Of NK T Cell Activation Protein Binding	Myosin V Binding Exocytosis Regulation Of Exocytosis GTP-dependent Protein Binding Secretion By Cell Secretion Regulation Of Secretion By Cell Regulation Of Secretion Synaptic Vesicle Regulation Of Vesicle-mediated Transport Positive Regulation Of Exocytosis Positive Regulation Of Secretion By Cell Vesicle-mediated Transport In Synapse GTPase Activity Positive Regulation Of Secretion Regulated Exocytosis GTP Binding Regulation Of Regulated Secretory Pathway Synaptic Vesicle Membrane Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Priming Vesicle-mediated Transport GDP Binding Regulation Of Transport Regulation Of Neurotransmitter Secretion Synaptic Vesicle Exocytosis Secretory Granule Calcium-ion Regulated Exocytosis Establishment Of Vesicle Localization Protein Domain Specific Binding Positive Regulation Of Transport Synaptic Vesicle Transport Acrosomal Vesicle Exocytosis Terminal Bouton Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Presynaptic Active Zone Vesicle Localization Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Regulated Secretory Pathway Organelle Localization Regulation Of Synaptic Vesicle Exocytosis Maintenance Of Presynaptic Active Zone Structure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Establishment Of Protein Localization Endosome Presynaptic Active Zone Organization Vesicle Docking
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