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KHDRBS3 and FUS
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
KHDRBS3
FUS
Description
KH RNA binding domain containing, signal transduction associated 3
FUS RNA binding protein
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Protein-containing Complex
Nucleus
Nucleoplasm
Cytoplasm
Glutamatergic Synapse
GABA-ergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Molecular Function
Nucleic Acid Binding
RNA Binding
MRNA Binding
Protein Binding
SH3 Domain Binding
Protein Domain Specific Binding
Identical Protein Binding
Nucleic Acid Binding
DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Metal Ion Binding
Molecular Condensate Scaffold Activity
Biological Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Processing
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
RNA Splicing
Gene Expression
Regulation Of RNA Splicing
Positive Regulation Of DNA-templated Transcription
MRNA Stabilization
Protein Homooligomerization
Membraneless Organelle Assembly
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Amyloid Fibril Formation
Pathways
PTK6 Regulates Proteins Involved in RNA Processing
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
Myxoid liposarcoma
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS
Chronotype (
30696823
)
Colorectal cancer (
34062886
)
Disease progression in age-related macular degeneration (
29346644
)
Polycystic ovary syndrome (
25574032
)
Squamous cell lung carcinoma (
28604730
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
HDL cholesterol levels (
32203549
)
Interacting Genes
59 interacting genes:
AQP1
BAHD1
CACNA1A
CCDC187
CCDC33
CNNM3
CPSF7
DMRT3
DOCK2
FBXO7
FUS
FXR1
HBZ
HNRNPC
HNRNPK
HNRNPR
INPP5D
KHDRBS1
KHDRBS2
LMNTD2
LNX1
MARK4
MYPOP
NCOA5
NELFB
NUDT18
OGT
PCDHB14
PPP1R13B
PRMT1
PRPF31
PRR3
PSMA1
PSMF1
PTBP2
RASAL3
RASD1
RBBP6
RBM3
RBM7
RBMX
RBMY1A1
RFC3
RPH3AL
SGSM2
SIAH1
SNRPC
SNX18
SRSF9
TSGA10IP
TYK2
U2AF2
WWP2
YTHDC1
ZNF326
ZNF408
ZNF575
ZNF580
ZNF688
122 interacting genes:
ADAMTS9-AS2
AKT1
ARID1A
ATM
ATXN1L
BACH2
BCL2L13
CEBPA
CREBBP
CTNNB1
ESRRA
FNDC3B
GRIN1
GRIN2D
IL7R
ILF3
ISG15
KHDRBS3
MAX
MDH1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NKD2
OGT
PDE4B
POLR2A
PRMT1
PSMB7
PTBP1
RELA
RXRA
SAFB2
SF1
SFPQ
SMARCB1
SMARCC1
SMARCC2
SMARCD1
SPI1
SRRM1
SRSF10
SRSF2
SRSF4
SRSF9
SS18
SUV39H1
TDRD3
THRA
UBQLN2
WBP4
YBX1
ZMYM2
Entrez ID
10656
2521
HPRD ID
10007
00660
Ensembl ID
ENSG00000131773
ENSG00000089280
Uniprot IDs
O75525
A0AAQ5BIG2
P35637
Q13344
Q6IBQ5
PDB IDs
5EL3
5ELR
5ELS
5ELT
5EMO
2LA6
2LCW
4FDD
4FQ3
5W3N
5XRR
5XSG
5YVG
5YVH
5YVI
6BWZ
6BXV
6BZP
6G99
6GBM
6KJ1
6KJ2
6KJ3
6KJ4
6SNJ
6XFM
7CYL
7VQQ
Enriched GO Terms of Interacting Partners
?
Regulation Of RNA Splicing
MRNA Processing
Nucleic Acid Binding
Regulation Of MRNA Splicing, Via Spliceosome
RNA Splicing
Regulation Of MRNA Processing
RNA Processing
MRNA Binding
RNA Binding
Regulation Of MRNA Metabolic Process
MRNA Metabolic Process
Spliceosomal Complex
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Negative Regulation Of RNA Splicing
Negative Regulation Of MRNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Metabolic Process
Regulation Of RNA Metabolic Process
Nucleus
Negative Regulation Of MRNA Splicing, Via Spliceosome
MRNA Splice Site Recognition
Nucleic Acid Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Splicing
Negative Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Poly(U) RNA Binding
Protein-RNA Complex Assembly
MRNA Alternative Polyadenylation
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Gene Expression
Commitment Complex
Positive Regulation Of MRNA Splicing, Via Spliceosome
Nucleoplasm
Positive Regulation Of NK T Cell Proliferation
Positive Regulation Of Translation
Catalytic Step 2 Spliceosome
Protein-containing Complex Assembly
Positive Regulation Of NK T Cell Activation
Protein Binding
MiRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Regulatory NcRNA-mediated Gene Silencing
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
MRNA 3'-UTR Binding
Regulation Of Gene Expression
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Regulation Of Metabolic Process
Negative Regulation Of Translation
Extracellular Vesicle
MRNA Destabilization
RNA Destabilization
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Regulation Of MRNA Metabolic Process
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Cell Migration
Negative Regulation Of Developmental Process
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Cell Motility
Regulation Of Translation
Negative Regulation Of Vascular Endothelial Growth Factor Production
Regulation Of Angiogenesis
Negative Regulation Of Locomotion
Regulation Of Vasculature Development
Negative Regulation Of Cytokine Production
Positive Regulation Of MRNA Metabolic Process
Regulation Of MRNA Stability
Regulation Of RNA Stability
Negative Regulation Of Multicellular Organismal Process
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Signal Transduction
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Multicellular Organismal Development
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Endothelial Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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