INPP4A and CAPN1

Number of citations of the paper that reports this interaction (PMID 9110986)
11

Data Source:
HPRD (in vitro, in vivo)

		INPP4A	CAPN1
Gene Name		inositol polyphosphate-4-phosphatase, type I, 107kDa	calpain 1, (mu/I) large subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol-3,4-bisphosphate 4-phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Dephosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of IP2, IP, and Ins in the cytosol Metabolism of lipids and lipoproteins Phospholipid metabolism Inositol phosphate metabolism PI Metabolism	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		3 interactors: CAPN1 PIK3R1 SMAD1	50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM
Entrez ID		3631	823
HPRD ID		02949	00253
Ensembl ID		ENSG00000040933	ENSG00000014216
Uniprot IDs		Q96PE3	B2RDI5 B4DWH5 P07384
PDB IDs			1ZCM 2ARY
Enriched GO Terms of Interacting Partners?		NFAT Protein Import Into Nucleus Transcription Factor Import Into Nucleus Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Primary MiRNA Processing Osteoblast Fate Commitment Posttranscriptional Regulation Of Gene Expression SMAD Protein Complex Assembly Receptor Catabolic Process Cellular Response To Growth Factor Stimulus Mesodermal Cell Fate Commitment Wound Healing Response To Growth Factor Insulin-like Growth Factor Receptor Signaling Pathway Cardiac Muscle Cell Proliferation Response To Wounding Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To BMP Stimulus Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Growth Hormone Receptor Signaling Pathway Mesodermal Cell Differentiation Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Growth Hormone Stimulus Negative Regulation Of Osteoclast Differentiation Response To Organonitrogen Compound Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Muscle Tissue Growth Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of RNA Splicing Gene Silencing By MiRNA Negative Regulation Of Cell-matrix Adhesion Cellular Response To DsRNA Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Cartilage Development Negative Regulation Of Cell Death Posttranscriptional Gene Silencing Response To Growth Hormone Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Glucose Transport Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Myeloid Leukocyte Differentiation	Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress
Tagcloud ?		7a abcc2 carboplatin chemotoxicity dspr fecundity founder gemcitabine gpx4 inbred intercross interindividual mitomycin msh2 multiparent nalcn nonsynonymous ortholog orthologs posteriori priori qtl revolutionize rrm2 rrm2b segregating singly solute transposable	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Difference) ?		7a abcc2 carboplatin chemotoxicity dspr fecundity founder gemcitabine gpx4 inbred intercross interindividual mitomycin msh2 multiparent nalcn nonsynonymous ortholog orthologs posteriori priori qtl revolutionize rrm2 rrm2b segregating singly solute transposable	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Intersection) ?