INPP4A and CAPN1

Number of citations of the paper that reports this interaction (PubMedID 9110986)
0

Data Source:
HPRD (in vitro, in vivo)

		INPP4A	CAPN1
Description		inositol polyphosphate-4-phosphatase type I A	calpain 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Postsynaptic Density Membrane Early Endosome Membrane Nuclear Membrane Organelle Synapse Recycling Endosome Membrane	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Phosphatidylinositol-3,4-bisphosphate 4-phosphatase Activity Hydrolase Activity Phosphatase Activity Inositol-1,3,4-trisphosphate 4-phosphatase Activity Inositol-3,4-bisphosphate 4-phosphatase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of IP2, IP, and Ins in the cytosol	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984)	Urate levels ( 31578528)
Interacting Genes		3 interacting genes: CAPN1 PIK3R1 SMAD1	55 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		3631	823
HPRD ID		02949	00253
Ensembl ID		ENSG00000040933	ENSG00000014216
Uniprot IDs		Q96PE3	B2RDI5 B4DWH5 P07384
PDB IDs			1ZCM 2ARY 7W7O 7X79 8GX3
Enriched GO Terms of Interacting Partners?		NMDA Selective Glutamate Receptor Signaling Pathway Calcium-dependent Cysteine-type Endopeptidase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Population Proliferation Calpain Complex Self Proteolysis Mammary Gland Involution DNA-templated Transcription Primary MiRNA Processing Mesodermal Cell Fate Commitment Heteromeric SMAD Protein Complex Anti-Mullerian Hormone Receptor Signaling Pathway Homomeric SMAD Protein Complex Co-SMAD Binding Primary MiRNA Binding Osteoblast Fate Commitment Transcription By RNA Polymerase II SMAD Protein Complex Positive Regulation Of Cell Projection Organization Cell Fate Commitment Involved In Formation Of Primary Germ Layer DEAD/H-box RNA Helicase Binding Kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Activator Activity Phosphatidylinositol 3-kinase Complex, Class IA Insulin Binding Perinuclear Endoplasmic Reticulum Membrane 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol Kinase Activity Positive Regulation Of Focal Adhesion Disassembly Neurotrophin TRKA Receptor Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Phosphatidylinositol 3-kinase Regulator Activity T Follicular Helper Cell Differentiation ErbB-3 Class Receptor Binding Kinase Activator Activity Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Intracellular Chemical Homeostasis I-SMAD Binding Cardiac Conduction System Development Positive Regulation Of Dendrite Development Interleukin-18-mediated Signaling Pathway Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Enzyme-substrate Adaptor Activity Phosphatidylinositol 3-kinase Binding Receptor Catabolic Process Hindbrain Development Cellular Homeostasis	Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization
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