INPP4A

Description		inositol polyphosphate-4-phosphatase type I A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Postsynaptic Density Membrane Early Endosome Membrane Nuclear Membrane Organelle Synapse Recycling Endosome Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-3,4-bisphosphate 4-phosphatase Activity Hydrolase Activity Phosphatase Activity Inositol-1,3,4-trisphosphate 4-phosphatase Activity Inositol-3,4-bisphosphate 4-phosphatase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of IP2, IP, and Ins in the cytosol
Drugs
Diseases
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984)
Interacting Genes		3 interacting genes: CAPN1 PIK3R1 SMAD1
Entrez ID		3631
HPRD ID		02949
Ensembl ID		ENSG00000040933
Uniprot IDs		Q96PE3
PDB IDs
Enriched GO Terms of Interacting Partners?		NMDA Selective Glutamate Receptor Signaling Pathway Calcium-dependent Cysteine-type Endopeptidase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Population Proliferation Calpain Complex Self Proteolysis Mammary Gland Involution DNA-templated Transcription Primary MiRNA Processing Mesodermal Cell Fate Commitment Heteromeric SMAD Protein Complex Anti-Mullerian Hormone Receptor Signaling Pathway Homomeric SMAD Protein Complex Co-SMAD Binding Primary MiRNA Binding Osteoblast Fate Commitment Transcription By RNA Polymerase II SMAD Protein Complex Positive Regulation Of Cell Projection Organization Cell Fate Commitment Involved In Formation Of Primary Germ Layer DEAD/H-box RNA Helicase Binding Kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Activator Activity Phosphatidylinositol 3-kinase Complex, Class IA Insulin Binding Perinuclear Endoplasmic Reticulum Membrane 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol Kinase Activity Positive Regulation Of Focal Adhesion Disassembly Neurotrophin TRKA Receptor Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Phosphatidylinositol 3-kinase Regulator Activity T Follicular Helper Cell Differentiation ErbB-3 Class Receptor Binding Kinase Activator Activity Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Intracellular Chemical Homeostasis I-SMAD Binding Cardiac Conduction System Development Positive Regulation Of Dendrite Development Interleukin-18-mediated Signaling Pathway Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Enzyme-substrate Adaptor Activity Phosphatidylinositol 3-kinase Binding Receptor Catabolic Process Hindbrain Development Cellular Homeostasis
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