IL15RA and PIAS4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		IL15RA	PIAS4
Description		interleukin 15 receptor subunit alpha	protein inhibitor of activated STAT 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Transferase Complex
	Molecular Function	Cytokine Receptor Activity Protein Binding Protein Kinase Binding Interleukin-15 Receptor Activity	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity SUMO Ligase Activity
	Biological Process	Natural Killer Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Neuron Projection Development Response To Nutrient Levels Positive Regulation Of Natural Killer Cell Differentiation Interleukin-15-mediated Signaling Pathway Positive Regulation Of Phagocytosis	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Sumoylation Positive Regulation Of Protein Sumoylation Vitamin D Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of MRNA Stability Negative Regulation Of DNA-templated Transcription Limb Epidermis Development MRNA Destabilization Regulation Of Cellular Response To Stress Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Interleukin-15 signaling Interleukin-15 signaling	Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31619474 31959851) Asthma (bronchodilator response) ( 23508266) Atopic dermatitis ( 26482879) Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 23128233) Medication use (thyroid preparations) ( 31015401) Neuroblastoma (pediatric) ( 32599975) Soluble interleukin-2 receptor subunit alpha ( 26293465)	Chronic lymphocytic leukemia ( 28165464) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2	91 interacting genes: ACTN1 ALDOA AR AREL1 BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G GATA1 HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KNTC1 KPNB1 KRT18 LAMP2 LCE1D LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRKCZ PRPF40A PTN RBBP8 RIF1 RPA2 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNAI2 SNIP1 STIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TOP1 TOP2A TP53 TRIM27 TRIM32 TRIM38 UBE2I UBE2K VHL VIM YY1 ZBTB34 ZHX1 ZNF512B ZW10
Entrez ID		3601	51588
HPRD ID		03045	06910
Ensembl ID		ENSG00000134470	ENSG00000105229
Uniprot IDs		A0A0A0MS77 G8CVM3 Q13261	B3KMR4 Q8N2W9
PDB IDs		2ERS 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endocytosis Interleukin-15-mediated Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Cytokine Production Involved In Immune Response Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Regulation Of Phagocytosis Positive Regulation Of Lymphocyte Activation Positive Regulation Of Lymphocyte Differentiation Signal Transduction Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Mast Cell Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Transport Lymphocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Differentiation Cellular Response To Oxygen-containing Compound Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Kinase Activity Regulation Of Lymphocyte Activation Positive Regulation Of Phagocytosis Lymphocyte Differentiation Positive Regulation Of Natural Killer Cell Differentiation Leukocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Immune System Process Regulation Of Transport Interleukin-2-mediated Signaling Pathway Positive Regulation Of Immune Effector Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Kinase Activity Regulation Of Natural Killer Cell Differentiation T Cell Activation Regulation Of Cell Activation Positive Regulation Of Cellular Component Organization Cell Activation Transferase Activity Cellular Response To Nitric Oxide Mononuclear Cell Differentiation Cellular Response To Reactive Nitrogen Species Positive Regulation Of Cell-cell Adhesion Positive Regulation Of B Cell Differentiation	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process SMAD Protein Signal Transduction Chromatin Binding Positive Regulation Of Cell Differentiation DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heteromeric SMAD Protein Complex Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Developmental Process
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