IL15RA and AXL

Number of citations of the paper that reports this interaction (PMID 16308569)
16

Data Source:
HPRD (in vivo, in vitro)

		IL15RA	AXL
Gene Name		interleukin 15 receptor, alpha	AXL receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Nuclear Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Cytokine Receptor Activity Protein Binding	Phosphatidylserine Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Myosin Heavy Chain Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity
	Biological Process	Signal Transduction Cell Proliferation Cytokine-mediated Signaling Pathway	Neuron Migration Natural Killer Cell Differentiation Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Phagocytosis Inflammatory Response Signal Transduction Spermatogenesis Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Negative Regulation Of Lymphocyte Activation Positive Regulation Of Protein Kinase B Signaling Vagina Development Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways			Signaling by VEGF VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Asthma (bronchodilator response) ( 23508266) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		12 interactors: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2	21 interactors: ADAM10 CBL FBXO25 GAS6 GRB2 IL15RA IL2RG LCK NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3
Entrez ID		3601	558
HPRD ID		03045	00171
Ensembl ID		ENSG00000134470	ENSG00000167601
Uniprot IDs		G8CVM3 Q13261 Q3B769	M0R0W6 P30530
PDB IDs		2ERS 2Z3Q 2Z3R 4GS7	2C5D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Activation Positive Regulation Of Cellular Metabolic Process Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Interleukin-2-mediated Signaling Pathway Signaling Cell Communication Regulation Of Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Cell-cell Adhesion Response To Organic Substance Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Adhesion Regulation Of T Cell Activation Cellular Response To Nitric Oxide Response To Interleukin-2 Positive Regulation Of Protein Metabolic Process Positive Regulation Of Lymphocyte Differentiation Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Reactive Oxygen Species Positive Regulation Of Signal Transduction Positive Regulation Of Natural Killer Cell Differentiation Immune Response Response To Nitric Oxide Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Natural Killer Cell Differentiation Regulation Of Cell Death Positive Regulation Of Immune System Process Cellular Response To Reactive Nitrogen Species Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Lymphocyte Differentiation Response To Inorganic Substance Response To Stimulus Positive Regulation Of Natural Killer Cell Activation Regulation Of Intracellular Signal Transduction Positive Regulation Of Tissue Remodeling Response To Reactive Oxygen Species	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Growth Factor Blood Coagulation Hemostasis Cellular Response To Organic Substance Response To Peptide Hormone Cellular Response To Organonitrogen Compound Locomotion Response To Organic Substance Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Insulin Stimulus Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Cell Migration Wound Healing Movement Of Cell Or Subcellular Component Insulin Receptor Signaling Pathway Fc Receptor Signaling Pathway Signal Transduction Cell Motility Response To Insulin Response To Wounding Regulation Of Phosphorylation Immune System Process Signaling Platelet Activation Cell Communication Regulation Of Kinase Activity Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process
Tagcloud ?		acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation crlf2 csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il1a il1b il23a il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7	antiapoptotic ark augmented ax1 cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Difference) ?		acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation crlf2 csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il1a il1b il23a il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7	antiapoptotic ark augmented ax1 cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide pi3 postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Intersection) ?