AXL and IL15RA

Number of citations: 48 (PubMedID 16308569)
Data Source: HPRD (in vitro, in vivo)

		AXL	IL15RA
Name		AXL receptor tyrosine kinase	interleukin 15 receptor subunit alpha
Structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Receptor Complex Extracellular Exosome	Golgi Membrane Extracellular Region Nucleus Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Nucleotide Binding Virus Receptor Activity Phosphatidylserine Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Cytokine Receptor Activity Protein Binding Protein Kinase Binding Interleukin-15 Receptor Activity
	Biological Process	Neuron Migration Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Immune System Process Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Nervous System Development Positive Regulation Of Signal Transduction Negative Regulation Of Macrophage Cytokine Production Cell Migration Forebrain Cell Migration Cell Differentiation Platelet Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Lymphocyte Activation Symbiont Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Positive Regulation Of Pinocytosis Regulation Of Lymphocyte Activation Negative Regulation Of Lymphocyte Activation Neuron Apoptotic Process Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vagina Development Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Neutrophil Clearance Mononuclear Cell Differentiation Positive Regulation Of Viral Life Cycle Negative Regulation Of Dendritic Cell Apoptotic Process	Natural Killer Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Neuron Projection Development Response To Nutrient Levels Positive Regulation Of Natural Killer Cell Differentiation Interleukin-15-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		VEGFA-VEGFR2 Pathway	Interleukin-15 signaling Interleukin-15 signaling
Drugs		Fostamatinib Gilteritinib	None
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) HDL cholesterol ( 31170924 ) Heel bone mineral density ( 30598549 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Triglyceride levels ( 32154731 32203549 )	Alopecia areata ( 25608926 ) Asthma ( 31619474 31959851 ) Asthma (bronchodilator response) ( 23508266 ) Atopic dermatitis ( 26482879 ) Blood protein levels ( 30072576 ) Diisocyanate-induced asthma ( 25918132 ) Inflammatory bowel disease ( 23128233 ) Medication use (thyroid preparations) ( 31015401 ) Neuroblastoma (pediatric) ( 32599975 ) Soluble interleukin-2 receptor subunit alpha ( 26293465 )
Interacting Genes		24 interacting genes: ADAM10 CBL EGFR FBXO25 GAS6 GRB2 IL15RA IL2RG LCK MTDH NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3 UBC	12 interacting genes: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2
Entrez ID		558	3601
HPRD ID		00171	03045
Ensembl ID		ENSG00000167601	ENSG00000134470
Uniprot IDs		M0R0W6 P30530	A0A0A0MS77 G8CVM3 Q13261
PDB IDs		2C5D 4RA0 5U6B 5VXZ	2ERS 2Z3Q 2Z3R 4GS7
GO Terms Enriched among Interactors		Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Receptor Tyrosine Kinase Binding Leukocyte Activation Cell Activation Neurotrophin TRKA Receptor Binding Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Leukocyte Differentiation Positive Regulation Of Cell Activation Immune System Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Cell Activation Lymphocyte Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Lymphocyte Differentiation Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation 1-phosphatidylinositol-3-kinase Regulator Activity Positive Regulation Of Multicellular Organismal Process Ephrin Receptor Binding Insulin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Process Protein Kinase Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction T Cell Activation Cell Migration Regulation Of Programmed Cell Death Protein Phosphatase Binding Response To Growth Factor Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA	Positive Regulation Of Endocytosis Interleukin-15-mediated Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Cytokine Production Involved In Immune Response Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Regulation Of Phagocytosis Positive Regulation Of Lymphocyte Activation Positive Regulation Of Lymphocyte Differentiation Signal Transduction Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Mast Cell Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Transport Lymphocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Differentiation Cellular Response To Oxygen-containing Compound Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Kinase Activity Regulation Of Lymphocyte Activation Positive Regulation Of Phagocytosis Lymphocyte Differentiation Positive Regulation Of Natural Killer Cell Differentiation Leukocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Immune System Process Regulation Of Transport Interleukin-2-mediated Signaling Pathway Positive Regulation Of Immune Effector Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Kinase Activity Regulation Of Natural Killer Cell Differentiation T Cell Activation Regulation Of Cell Activation Positive Regulation Of Cellular Component Organization Cell Activation Transferase Activity Cellular Response To Nitric Oxide Mononuclear Cell Differentiation Cellular Response To Reactive Nitrogen Species Positive Regulation Of Cell-cell Adhesion Positive Regulation Of B Cell Differentiation