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AXL and IL15RA
Number of citations of the paper that reports this interaction (PubMedID
16308569
)
48
Data Source:
HPRD
(in vitro, in vivo)
AXL
IL15RA
Description
AXL receptor tyrosine kinase
interleukin 15 receptor subunit alpha
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Cell Surface
Actin Cytoskeleton
Membrane
Receptor Complex
Extracellular Exosome
Golgi Membrane
Extracellular Region
Nucleus
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Nuclear Membrane
Molecular Function
Nucleotide Binding
Virus Receptor Activity
Phosphatidylserine Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Cytokine Receptor Activity
Protein Binding
Protein Kinase Binding
Interleukin-15 Receptor Activity
Biological Process
Neuron Migration
Natural Killer Cell Differentiation
Negative Regulation Of Cytokine Production
Positive Regulation Of Cytokine-mediated Signaling Pathway
Blood Vessel Remodeling
Immune System Process
Phagocytosis
Apoptotic Process
Inflammatory Response
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Nervous System Development
Positive Regulation Of Signal Transduction
Negative Regulation Of Macrophage Cytokine Production
Cell Migration
Forebrain Cell Migration
Cell Differentiation
Platelet Activation
Negative Regulation Of Type II Interferon Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Differentiation
Secretion By Cell
Erythrocyte Homeostasis
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Interferon-alpha
Ovulation Cycle
Negative Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Negative Regulation Of Neuron Apoptotic Process
Innate Immune Response
Lymphocyte Activation
Symbiont Entry Into Host Cell
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell Maturation
Positive Regulation Of Pinocytosis
Regulation Of Lymphocyte Activation
Negative Regulation Of Lymphocyte Activation
Neuron Apoptotic Process
Establishment Of Localization In Cell
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Vagina Development
Cellular Response To Lipopolysaccharide
Dendritic Cell Differentiation
Neutrophil Clearance
Mononuclear Cell Differentiation
Positive Regulation Of Viral Life Cycle
Negative Regulation Of Dendritic Cell Apoptotic Process
Natural Killer Cell Differentiation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Neuron Projection Development
Response To Nutrient Levels
Positive Regulation Of Natural Killer Cell Differentiation
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of Phagocytosis
Pathways
VEGFA-VEGFR2 Pathway
Interleukin-15 signaling
Interleukin-15 signaling
Drugs
Fostamatinib
Gilteritinib
Diseases
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
HDL cholesterol (
31170924
)
Heel bone mineral density (
30598549
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Triglyceride levels (
32154731
32203549
)
Alopecia areata (
25608926
)
Asthma (
31619474
31959851
)
Asthma (bronchodilator response) (
23508266
)
Atopic dermatitis (
26482879
)
Blood protein levels (
30072576
)
Diisocyanate-induced asthma (
25918132
)
Inflammatory bowel disease (
23128233
)
Medication use (thyroid preparations) (
31015401
)
Neuroblastoma (pediatric) (
32599975
)
Soluble interleukin-2 receptor subunit alpha (
26293465
)
Interacting Genes
24 interacting genes:
ADAM10
CBL
EGFR
FBXO25
GAS6
GRB2
IL15RA
IL2RG
LCK
MTDH
NCK2
PIK3R1
PIK3R2
PIK3R3
PLCG1
PTPN11
RANBP9
SHC1
SHC3
SOCS1
SRC
TNS2
TYRO3
UBC
12 interacting genes:
AXL
BCL10
CASK
CDK2
CDK4
IL15
IL2RB
IL2RG
PIAS4
RCVRN
SYK
TRAF2
Entrez ID
558
3601
HPRD ID
00171
03045
Ensembl ID
ENSG00000167601
ENSG00000134470
Uniprot IDs
M0R0W6
P30530
A0A0A0MS77
G8CVM3
Q13261
PDB IDs
2C5D
4RA0
5U6B
5VXZ
2ERS
2Z3Q
2Z3R
4GS7
Enriched GO Terms of Interacting Partners
?
Phosphotyrosine Residue Binding
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Receptor Tyrosine Kinase Binding
Leukocyte Activation
Cell Activation
Neurotrophin TRKA Receptor Binding
Mononuclear Cell Differentiation
Positive Regulation Of Lymphocyte Activation
Regulation Of Lymphocyte Activation
Leukocyte Differentiation
Positive Regulation Of Cell Activation
Immune System Process
Positive Regulation Of Immune System Process
Signal Transduction
Regulation Of Cell Activation
Lymphocyte Activation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Signal Transduction
Regulation Of Immune System Process
Lymphocyte Differentiation
Regulation Of Cell Adhesion
Regulation Of Intracellular Signal Transduction
Positive Regulation Of T Cell Activation
1-phosphatidylinositol-3-kinase Regulator Activity
Positive Regulation Of Multicellular Organismal Process
Ephrin Receptor Binding
Insulin Receptor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Multicellular Organismal Process
Protein Kinase Binding
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of MAPK Cascade
Intracellular Signal Transduction
T Cell Activation
Cell Migration
Regulation Of Programmed Cell Death
Protein Phosphatase Binding
Response To Growth Factor
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Phosphatidylinositol 3-kinase Complex, Class IA
Positive Regulation Of Endocytosis
Interleukin-15-mediated Signaling Pathway
Regulation Of Production Of Molecular Mediator Of Immune Response
Regulation Of Cytokine Production Involved In Immune Response
Regulation Of Endocytosis
Regulation Of Vesicle-mediated Transport
Interleukin-15 Receptor Activity
Interleukin-2 Binding
Interleukin-2 Receptor Activity
Regulation Of Phagocytosis
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Lymphocyte Differentiation
Signal Transduction
Immune Response
Positive Regulation Of Cell Activation
Positive Regulation Of Mast Cell Cytokine Production
Regulation Of Cytokine-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Positive Regulation Of Leukocyte Differentiation
Positive Regulation Of Transport
Lymphocyte Activation
Cell Surface Receptor Signaling Pathway
Regulation Of Lymphocyte Differentiation
Cellular Response To Oxygen-containing Compound
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Kinase Activity
Regulation Of Lymphocyte Activation
Positive Regulation Of Phagocytosis
Lymphocyte Differentiation
Positive Regulation Of Natural Killer Cell Differentiation
Leukocyte Activation
Positive Regulation Of T Cell Activation
Positive Regulation Of Immune System Process
Regulation Of Transport
Interleukin-2-mediated Signaling Pathway
Positive Regulation Of Immune Effector Process
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Leukocyte Cell-cell Adhesion
Kinase Activity
Regulation Of Natural Killer Cell Differentiation
T Cell Activation
Regulation Of Cell Activation
Positive Regulation Of Cellular Component Organization
Cell Activation
Transferase Activity
Cellular Response To Nitric Oxide
Mononuclear Cell Differentiation
Cellular Response To Reactive Nitrogen Species
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of B Cell Differentiation
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